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These manipulations were designed to test major regulators of renin release, including angiotensin II, the macula densa, renal perfusion pressure, and beta-adrenergic receptors. Comparison of primary care physician payment models in the management of hypertension. Report on the 5th annual meeting of the Societas Europea Pneumologica and the 21st annual meeting of the Societas Europea Physiologiae Clinicae Respiratoriae.

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Evaluation of microparticle enzyme immunoassay against HPLC-mass spectrometry for the determination of whole-blood tacrolimus in heart- and lung-transplant recipients. The cortical screw developed an anchoring force of 59 N/mm and the cancellous screw, 63 N/mm. Analysis of the 11 patients in whom cancer was proved eventually reveals 14 distinct periods, ranging from 1 to 37 months, in which cytologies were abnormal and concurrent clinical examinations and histological diagnoses were negative. Regulation of alpha 1-antichymotrypsin synthesis in cells of epithelial origin.

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Substantial progress has been made recently in determining functions and mechanisms of reactive astrogliosis and in identifying roles of astrocytes in CNS disorders and pathologies. To study the potential mechanism responsible for the action of TIP39 in the dermis, fibroblasts were cultured in three-dimensional collagen gels, a process that results in enhanced decorin expression unless activated to differentiate to adipocytes, whereupon these cells reduce expression of several proteoglycans, including decorin.

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The interplay of geometry, topology, and chemistry is explored within the Landauer picture of elastic scattering and various methods of quantum description of the composite system. Transovarially acquired Lyme disease spirochetes (Borrelia burgdorferi) in field-collected larval Ixodes dammini (Acari: Ixodidae). Prohormone convertase 2 (PC2) belongs to a family of enzymes involved in the proteolytic maturation of neuropeptide precursors into mature peptides that act as neurotransmitters, neuromodulators or neurohormones. Effects of strain, behavior and age on the self-administration of ethanol, nicotine, cocaine and morphine by two rat strains. Baseline measures of noradrenergic function in patients with posttraumatic stress disorder (PTSD) have also been mixed, while an increased heart, blood pressure and norepinephrine response to traumatic reminders, as well as increased behavioral (as well as different brain metabolic) response to yohimbine, have been found in PTSD.

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It may be repaired using open suture, open mesh or laparoscopic mesh techniques. Periarteritis nodosa is a disease of small and medium-sized arteries, frequently associated with multiple visceral artery aneurysms. Its localization within endothelial cells has not been determined, nor the mechanisms by which it might be released from endothelial cells during normal organogenesis. The anterior extraperitoneal approach enables access to the spine. Results concerning MAO and COMT activities are now sufficiently inconsistently characteristic of schizophrenics as to question their clinical applicability and to indicate a need for further critical evaluation, with special attention to diagnosis, matching of subjects, and effects of possible spurious environmental variables.

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Flavivirus envelope proteins are N-glycosylated surface proteins, which interact with C-type lectins, dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) through their glycans. Genetic counselling in unexpected familial recurrence of achondroplasia. Antiallodynic effect of intrathecal neostigmine is mediated by spinal nitric oxide in a rat model of diabetic neuropathic pain. Although animal models have also yielded contradictory conclusions, it is intriguing to note that the abnormalities observed in these models are similar to those seen clinically.

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These results suggest that the PSG3 epitope on GPIIIa contains a particular array of negative charges, and possibly affects the fibrinogen binding to GPIIb/IIIa complex necessary for platelet aggregation. Treatment of closed humeral shaft fractures with intramedullary elastic nails. Influence of intensive diabetes treatment on body weight and composition of adults with type 1 diabetes in the Diabetes Control and Complications Trial. To compare the efficacy of ranitidine bismuth citrate (RB) combined with two antibiotics during seven days in comparison with OCA-7 for treatment of Helicobacter pylori. The specific aims should be justified by the need for the conference and articulated in the background and significance section, and the aims, in turn, should drive the content and format of the conference.

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Colcemid at a sublethal concentration, and growth on medium solidified with agar also evoked pigment production in this line, but a large number of other inhibitors of biosynthetic processes did not, under the conditions tested. In this study we compare the status and function of wild-type p53 in MCF-7 breast cancer cells with sublines selected for resistance to chemotherapeutic agents having different mechanisms of action. Two cases of adenomyoma of the small intestine occurring in two young children are described.

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Length of urethral stricture (greater than 4 cm), prior urethroplasty and failed endoscopic therapy are predictive of failure after urethroplasty. Factors related to the relapse of bronchiolitis obliterans organizing pneumonia. Forty consecutive primigravid women, judged to be at low risk at the start of labour, in each hospital.

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Sorption kinetics and breakthrough curves for pepsin and chymosin using pepstatin A affinity membranes. It is imperative that any pathogenetic model for schizophrenia takes into account what is now known about genetic mechanisms of illness. We isolated a mutant MinE containing residue substitutions in R10, K11 and K12 that was fully capable of stimulating MinD ATPase activity, but was deficient in membrane binding. Increases in the number of GABAergic neurons and a reduced effectiveness of iontophoretically-applied GABA are observed in the IC of this animal. Bacteria engineered with the gene (vgb) encoding Vitreoscilla hemoglobin (VHb) typically produce more protein than unengineered cells, and it has generally been assumed that VHb is responsible for this effect.

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Third, the characteristic scale selection is performed to calculate the radius of each GIR. The investigation of the qualitative and quantitative distribution of the collagen fibrils has been very useful for understanding the structural and functional alterations that occur during the aging process. The authors conclude that, whereas language is certainly associated with many barriers to health care, both economic well-being and having a usual source of care are of paramount importance for the Hispanic American population. The sequence of this C-terminal extension is homologous to an interhelical loop found in several membrane proteins, including mitochondrial transport proteins, suggesting a possible mode of interaction with the inner mitochondrial membrane.

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Balloon pericardiostomy: a new therapeutic option for malignant pericardial effusion. Knowledge of the requirement for these genes in the embryo and in embryonic stem cells will advance our understanding of how to reverse the developmental clock for therapeutic benefit.

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A chicken genomic clone that contains at least part of the coding region for the GS enzyme was used to investigate developmental changes in the level of GS mRNA in embryonic chicken retina. Two pregnancies with in utero left ventricular aneurysm, both involving the apex, were referred for fetal atrial arrhythmias at 28 and 25 weeks of gestation, respectively.

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Arachidonic acid (20:4(n-6)), which is released by cells responding to a wide range of stimuli, may play an important role in intracellular signaling. VMAT2 ko mice, completely lacking activity-dependent vesicular release of monoamines including 5-HT, also show a complete lack of 5-HT in the cortex but display largely normal barrel fields, despite sometimes markedly reduced postnatal growth. DNA fragmentation and ultrastructural changes in the brain of rabbits treated with vincristine.

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Serial rib fractures and flail chest injury can be treated by positive-pressure ventilation. The objective of this article is to present an analysis of soft tissue response to nonsurgical therapy at buccal and interproximal sites, using several cases to illustrate.

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coli O157:H7 were reported more frequently than in previous years and were associated primarily with recreational lake water. A study investigates gender differences of nurse executives on a variety of managerial attributes: sex role, supervision, power, career commitment and work/family conflict. In addition, although SIVmac239 and SIVmac316 use different structural domains of the CCR5 receptor for entry, both viruses stimulate early phosphorylation of MEK, ERK, p38, and JNK independently of their tropism and replication.

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Cyclosporin A, a hydrophobic cyclic peptide, is a potent immunosuppressant. Positive bethanechol supersensitivity test in neurologically normal patients. Results from the analysis of gene expression profiles indicated that there were 65 genes upregulated and 28 genes downregulated more than two-fold in all three experimental pairwise comparisons.

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Food consumption in the period of pregnancy decreased in the dams given 100 and 300 mg/kg, and food and water consumption during lactational period increased in the dams given 300 mg/kg. In rat specimens, the long/short axes ratio of nuclei of normal skin, at 15 and 5 min ante-mortem and at 5 min postmortem injury, the mean epithelial basal cells was 1.4124, 4.5417, 5.2282 and 5.0447, respectively. Significantly lowered sulphur values were found in type II A and II B muscle fibres of RA patients as compared to those of healthy controls. Case of primary hematogenic tuberculosis of the flexor muscles of the leg In order to develop systems for the delivery of IL-1ra to mucosal target sites, a Streptococcus gordonii strain secreting human IL-1ra was constructed.

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The monoamine content and other parameters of cerebrospinal fluid (CSF) were studied in aneurysmal subarachnoid haemorrhage (ASH). Excitable waves and direction-sensing in Dictyostelium discoideum: steps towards a chemotaxis model.

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Therefore, we later discuss scaffold properties required for brain cell therapy as well as new tissue engineering advances that may be implemented in combination with adult cells for brain therapy. Cloning and nucleotide sequencing of the protease gene of Vibrio vulnificus. Subsequently, tuberculosis sepsis and prosthesis infection resulted in long-term antibiotic treatment. We now show that, whereas blockade of either the extracellular signal-regulated kinase (ERK) pathway or the phosphatidylinositol 3-kinase (PI3K)-Akt pathway alone induced only a low level of cell death, it markedly sensitized NSCLC or CML cells to the induction of apoptosis by histone deacetylase (HDAC) inhibitors. Enhancement of the opioid cataleptic response was not due to changes in the availability of the drugs in the brain.

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This suggests that, by increasing gene copy number, localized endoreduplication serves as a mechanism to meet the enhanced metabolic demands imposed by the fungus, which acquires all its nutrients from the plant host. Src is a non-receptor protein tyrosine kinase that transduces signals that are involved in the control of a variety of cellular processes such as proliferation, differentiation, motility, and adhesion. A broad range of compounds including primary, secondary and lipophilic metabolites were analyzed by a combination of gas (GC) and liquid chromatography (LC) mass spectrometry (MS) based methods. Physiology of chemoreceptor cells in the legs of the freshwater prawn, Macrobrachium rosenbergii.

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Covariates of interest included center-specific cumulative number of PD patients treated, percentage of patients who initiated dialysis on PD, and academic status. In contrast, serum leptin levels did not change significantly after cure of H pylori infection.

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We then analyzed empirical findings using four theoretical lean principles (Spear and Bowen 1999) to understand how and why the intervention worked in its local context as well as to identify its strengths and weaknesses. The SAH domain was inserted between the IQ motifs and the coiled coil in a Myo5 HMM construct in which the levers were truncated from six to two IQ motifs (Myo5-2IQ). The ability of oral Streptococcus strains to utilize oligosaccharide chains in mucin as a source of carbohydrate was studied in batch cultures. Migrating MICs are guided by the same CXCR4/CYCL12 axis as used in the migration of primordial germ cells to the genital ridge.

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However, this prognosis seems to improve with early and adapted treatment based largely at this time on beta-blockers and calcium inhibitors. This study aimed to describe county-level trends in the prevalence of poor self-reported health and to assess the face validity of these estimates. In this article, the authors describe the anesthetic management of the radiofrequency ablation of a pulmonary neoplasm complicated by massive hemorrhage. A pair of chimeric recombinant viruses in which the nucleocapsid gene was exchanged between JHM and A59 was selected and compared to wild-type parental strains in terms of virulence.

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These results suggest an essential role of E2F1-mediated transcription in its inhibition of myogenesis. A general system is described that facilitates gene replacements such that the recombinant strains are not labelled with antibiotic resistance genes. Serum ferritin and tissue ferritin from kidney, heart, small intestine, spleen and liver from ducks during development from 16 to 112 days of age were measured by radioimmunoassay using rabbit anti-duck liver ferritin antibodies and goat second antibody. Comparisons of the transferability of plasmids pCAR1, pB10, R388, and NAH7 among Pseudomonas putida at different cell densities.

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The pulmonary artery and vein strips were less extensible in the older age groups, the main change occurring in the elastic phase of the vascular stress/strain curves. Current challenges in walking surveillance include ensuring that both researchers and respondents understand WERS in a standardized manner.

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Deep breathing in children with severe malaria: indicator of metabolic acidosis and poor outcome. This gene is preferentially expressed in young cells and has a life span-extending effect on yeasts. The production of interleukin 6 (IL-6) was examined in premature neonates (48 cases, including 3 miscarried fetuses) and fullterm neonates (20 cases).

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Not only was R75W alone incapable of inducing electrical conductance between adjacent cells, but it almost completely suppressed the activity of co-expressed wildtype protein. Mutants compromised in function of the Mlo wild-type gene and the Ror1 gene (genotype mlo5 ror1) that are moderately susceptible to B. Use of the Beck Anxiety Inventory with adolescent psychiatric outpatients. Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration. The case of a patient with progressive paraparesis due to first thoracic disc herniation is reported.

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Carbamazepine and phenytoin were superior to sodium valproate in treating both familial and sporadic PKD patients, and both drugs resulted in almost complete remission of attacks. These findings suggest a tight relationship between dopaminergic and serotonergic systems of the lateral hypothalamic area and ventromedial hypothalamus, which is influenced by the feeding state and which may be involved in maintaining the balance within and between the centers of the parasympathetic and sympathetic nervous systems. A score for quantitative evaluation of the severity of clinical status has been created for a more objective assessment of the clinical status of patients with sepsis and septic shock. Oxidative transformation of micropollutants during municipal wastewater treatment: comparison of kinetic aspects of selective (chlorine, chlorine dioxide, ferrate VI, and ozone) and non-selective oxidants (hydroxyl radical).

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However, when administration of DMXAA preceded irradiation, the effect was similar to that seen for radiation alone, suggesting that appropriate timing is essential to maximize the utility of this agent. Phrenitis in the Hippocratic Corpus: a philological and medical study Three models of hypercholesterolemia in rabbits were positively associated with plasma cholesteryl ester and triglyceride transfer activities. Serological cross-reactions of aqueous ether extracted endotoxin from Neisseria gonorrhoeae strains. A double-blind, placebo-controlled trial of decongestant-antihistamine for the treatment of sinusitis in children.

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Long-term studies of the fate and function of maximal-length vena cava autografts to bridge experimental aortic defects in dogs. The isoenzyme patterns of 92 isolates of Entamoeba histolytica from British Columbia and 28 from Ontario were determined. MRI of the temporo-mandibular joint: which sequence is best suited to assess the cortical bone of the mandibular condyle?

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Cells were made to rotate backward, that is, in the direction opposite to the rotation driven by the flagellar motor itself. These proteins including GntT and GntU appear to have similar topological structures with 14 membrane-spanning segments, suggesting that they constitute a GntP family.

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A laser iridotomy counts as a standard procedure in cases of acute angle closure, whereas there are no coherent recommendations or guidelines for a prophylactic therapy. Three-dimensional composite of demineralized bone powder and collagen for in vitro analysis of chondroinduction of human dermal fibroblasts.

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The predictability of the measurement of the macular function by white light interferometry was evaluated in a group of patients whose epiretinal membranes had been surgically removed. Neurobehavioral evidence for changes in dopamine system activity during adolescence. Among the clinical complications of mechanical heart valves (MHVs), hemolysis was previously thought to result from Reynolds stresses in turbulent flows.

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We will argue that these differences are due to the optical properties of water and that the differences have relevance for theories of visual receptive fields. One and one half ventricle repair for pure pulmonary atresia--a case report