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Topamac (Topiramate)
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Topiramate

Topamac is an oral drug that is used to prevent the seizures of epilepsy. It is an anti-epileptic or anti-seizure drug. It is used primarily among patients who are not controlled by other anti-epileptic drugs. About 1 in 4 Americans diagnosed with epilepsy has seizures that resist treatment with other anti-epileptic drugs. Topamac also prevents migraine headaches. Seizures are due to the abnormal activity ("firing") of nerves in the brain, and the abnormal activity spreads to smaller or larger portions of the brain. Although Topamac's exact mechanism of action is unknown, scientific studies suggest that it may alter neurotransmitters within the brain. Neurotransmitters are chemicals that nerves manufacture and use to communicate with other nearby nerves. By altering the production or action of the neurotransmitters, Topamac may suppress the abnormal activity of the nerves in the brain that cause the seizures or may prevent the abnormal activity from spreading to other nerves. Other studies suggest that Topamac may suppress the nerves directly (i.e., not by altering neurotransmitters) and make them less likely to fire. The FDA approved Topamac as a tablet in 1997. The sprinkle capsules were approved in October 1998.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Population Pharmacokinetic Modeling of Tapentadol Extended Release (ER) in Healthy Subjects and Patients with Moderate or Severe Chronic Pain. major-resistant (C57BL/6) and susceptible (BALB/c) strains of mice with anti-CD86 substantially decreased parasite burden. We believe that the use of immunologic adjuvants together with DNA vaccines is a promising way to enhance and optimize DNA-derived immunity. Adjusted ionized calcium (at pH 7.4) and actual ionized calcium (at actual pH) in capillary blood compared for clinical evaluation of patients with disorders of calcium metabolism.

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We reported previously that vascular endothelial growth factor (VEGF) inhibits the apoptotic death of hematopoietic cells that is induced by exposure to ionizing radiation (O. The average age of patients with lung cancer is increasing, but there is little data of the management and outcomes of this common cancer in the elderly. Older children usually present with a multisystem disease similar to the adult manifestation, with frequent hilar lymphadenopathy and pulmonary infiltration. The strength of our approach lies in the identification, for the first time, of specific depletion kinetics of four sulphur containing compounds occurring during fermentation (hydrogen sulphide, methanethiol, S-methyl thioacetate/S-ethyl thioformate, pentane-thiol), which suggest a new possible protechnological feature of yogurt starter cultures. Its specific activity (20 units/mg protein) and amino acid composition showed a strong similarity to that of the Mycoplasma arthritidis arginine deiminase.

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In the present study, we examined whether this phonological similarity decrement is present when additional semantic information is available, as in a reading span test, as compared with a standard presentation, or in the context of an operation span test. In a case-control study, a two stage screening procedure was used to ascertain the prevalence of RA in 518 first degree relatives of 207 Norfolk Arthritis Register cases registered in 1990 and 414 first degree relatives of 180 local controls. These osZIP-2 factors represent a novel class of bZIP proteins with an unusual DNA-binding domain that does not recognize G-boxes.

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Effect of probenecid on ventricular cerebrospinal fluid methotrexate pharmacokinetics after intralumbar administration in nonhuman primates. Furthermore, the action of a potential therapeutic agent, relaxin (RLN) acting through its cognate G-protein coupled receptor (RXFP1) on the surface of activated HSC shows promise. After ceasing intravenous immunoglobulin, azathioprine (up to a dose of 1 mg/kg/day) was used to adequately control her pemphigoid gestationis. On the other hand, VEGF-A and VEGF-C have equipotent biological activities on EC in absence of NRP-1. By calculating the eye movement direction in head co-ordinates we are able to relate the elicited nystagmus very precisely to a particular canal and thereby localize the lesion.

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Thirty-one healthy women with a median age of 55 years comprised the study population. Melanin causes the cytoplasm of pigmented cells to appear bright. In response to LPS, MKP5-deficient macrophages produced significantly more inflammatory factors including inflammatory cytokines, nitric oxide, and superoxide. Levels of vitamin K-dependent factors, additional coagulation factors, and thrombin-antithrombin complexes (marker of thrombin generation). Future therapeutic advances, based on the precise genetic etiology, are anticipated.

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Both giant cells and syncytia undergo extensive cell wall architectural modifications, including thickening and the formation of numerous ingrowths that increase the plasmalemma surface area for solute uptake. Intestinal absorption of immunologically intact macromolecules in germfree colostrum-deprived piglets maintained on total parenteral nutrition. This model contains several factors of stress like rapid eye movement (REM) sleep deprivation, isolation, immobilization and falling into the water. This has been the first report that plasma kinetics of a liposomal formulation with a low PEG density followed linear kinetics.

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Differences in physical, emotional, and social adjustment of intimate, family, and nonfamily patient-partner dyads based on a breast cancer intervention study. Twenty-five patients with colorectal carcinoma were tested for blood-lymphocyte anti-tumour cytotoxicity and carcinoembryonic antigen (CEA) levels at three-monthly intervals for eighteen months or more after resection, and examined clinically every three to six months. 3 The effect of the two drugs, administered at equiactive antisecretory doses, on gastric emptying was different. Oral movement activity was recorded 2 days before and 7 days after the acute injection of haloperidol using a computerized scoring apparatus.

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A retrospective study of all patients, undergoing rectal cancer surgery during the period January 1981-December 1987. Deletion mutations are predicted to cause a loss of protein function, providing strong evidence that ALS2 is the causative gene underlying this form of ALS. Agreement for most comparisons involving diagnoses of current dependence ranged from good to excellent, with no clear pattern of lower agreement for DSM-III.

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Moreover, IFN-gamma treatment increased RAR-alpha and RAR-gamma expression. Intracerebroventricularly administered bradykinin augments carrageenan-induced paw oedema in rats. Identification of Tah11/Sid2 as the ortholog of the replication licensing factor Cdt1 in Saccharomyces cerevisiae.

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In the absence of EGF progenitor cells differentiated into tyrosine hydroxylase (TH)-immunoreactive neuronal and TH-negative flat cells. Critical testing of this model is necessary to generalize it to other membrane proteins. The isolation of Brucella abortus from a waterbuck (Kobus ellipsiprymnus). Their demographic variables, length of illness and severity of psychotic symptoms were analyzed for insight. Excised dry and wet human femora, as well as a model system consisting of a bar of strongly piezoelectric ceramic, were examined using the device.

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These results have implications for outbreak management and treatment of influenza among military recruits. Both concurrent and retrospective items contributed significantly to measurement of a single latent construct.

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Tumoral progression of human breast epithelial cells secreting FGF2 and FGF4. We describe here a case of atrial septal aneurysm with no other cardiac abnormalities that was diagnosed by two-dimensional echocardiography. IgG2a, which was only modestly efficient at C1q binding, was relatively more so for binding and activation of while C1, and was by far the most effective isotype after IgG2b and IgM for C4 and C3 binding. These MNCs had tartrate-resistant acid phosphatase (TRAP) activity and strong ability to resorb dentine.

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Blue toe syndrome commonly occurs as a result of aneurysmal or atherosclerotic disease in the iliac arteries. After the grafts were allowed to mature in oculo, ingrowing adrenergic and cholinergic fibers from the iris were activated by changing the illumination of the retina. Ottowa conference for health promotion--on the way to a new understanding of public health In this work, we propose to explicitly study the local frequency distribution of intensity values in broader neighborhoods centered around each voxel.

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The Diabetic Control and Complications Trial (DCCT) researchers kept careful records of the food consumption and tobacco using habits of type 1 diabetic subjects. Posttraumatic pulmonary pseudocysts as a manifestation of child abuse. Recent changes in European Union legislation legally mandate HACCP in pork slaughter plants. DTZ cream caused substantially fewer headaches than GTN ointment. Structured lifestyle and food frequency questionnaires are administered.

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The active peptide (AdTx1) was sequenced by Edman degradation and mass spectrometry fragmentation. They also show that VP1 VLPs are very immunogenic, inducing high proliferative cell responses and both serum and mucosal antibodies. This discussion will focus on the regulation of peripheral cell numbers by the antigen-independent proliferation of T cells, which has recently been demonstrated to contribute to the maintenance and recovery of lymphocyte homeostasis. In the other case, we tried to discriminate AFib from non-AFib using support vector machine with the other feature measures: the mean stepping increment and dispersion of the points in the Poincare plot. Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23.

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The Arg P13/Thr substitution led to a greatly impaired reactivity with the antibody, whereas the Ala P9/Ile mutation resulted in a modest loss of reactivity with the antibody. We identified largely distinct but overlapping profiles of REST and CoREST target genes during neuronal subtype specification including a disproportionately high percentage that are exclusive to each neuronal subtype.

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Change in the chemical sensitivity of the visual cortical synapses in rabbit ontogeny Although this clinical presentation has not been described as compartment syndrome, one similar presentation was described in the literature. Since victims of cardiac arrest have a more favorable outcome when CPR is immediately applied, it is important to continue to motivate individuals to learn proper technique. The usual analysis of incidental tumors, which adjusts for survival by stratifying the animals according to age at death, has various shortcomings. The terminal field from the upper eyelid was located ventrally in the pars caudalis, and that from the lower eyelid was located more dorsally.

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the mechanism by which ifosfamide causes renal tubular damage is not well understood, but it appears to involve metabolites of the drug. rAAV was found to transduce the basolateral surface of airway epithelia 200-fold more efficiently than the apical membrane. Direct Revascularization with Autotransplant Technique for a True Aneurysm of the Renal Artery 20 Years after Kidney Transplantation. Analysis of the renal transplant waiting list at the National Taiwan University Hospital: eleven-year case review.

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We observed, however, an increased lymphocytic infiltration after challenge in single-vaccinated animals and hypothesize that this a side effect of the model. Direct sequencing of PCR-amplified products from host gill DNA with primers specific for Bacteria 16S rRNA genes gave a single, unambiguous sequence for each of the two symbiont species. Cloning and expression of the cutinase A gene of Botrytis cinerea. In vitro biotransformation of dynorphin A (1-17) is similar in human and rhesus monkey blood as studied by matrix-assisted laser desorption/ionization mass spectrometry. For the past two decades, the dominant methods to identify susceptibility genes of complex disease were linkage analysis and association study.

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Starting with 3.5 g of mycelial proteins, approximately 1 mg of pure enzyme was obtained. Living organ donors and families of nonliving donors could receive incentives of a noncoercive nature that would stimulate participation without sacrificing altruism. These multiple regulatory pathways take place during the entire life-span of T cells including T-cell development, homing, activation, and differentiation.

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Only traces of flecainide were detected in brain and fat tissues. Coadministration of naproxen and low-dose methotrexate in patients with rheumatoid arthritis. Effects of collateral circulation on electrophysiological properties during the acute phase of canine myocardial infarction.

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Observational studies have reported increased mortality rates in hyperkalaemic or hypokalaemic chronic haemodialysis patients. Isolated ambient hematomas are the result of injury to small vessels or of mild contusions of the brain stem produced by the edge of the tentorium. The pattern of both the heme methyl dominant contact shifts and the heme meso-proton dominant dipolar shifts are shown to be consistent with the orientation of the axial His. Shaping institution-based specialism: early twentieth-century economic organization of medicine. Somatostatin suppresses endothelin-1-induced rat hepatic stellate cell contraction via somatostatin receptor subtype 1.

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Glutamate microdrops (10-20 mM, 10-20 microns diam) increased the firing frequency of extracellularly recorded dentate granule cells for 5-10 s when applied to their somata but not when applied to their mossy fiber axons and terminals in the hilus and in CA3. The bundle-forming pili of enteropathogenic Escherichia coli: transcriptional regulation by environmental signals. N-Acyl Dehydrotyrosines, Tyrosinase Inhibitors from the Marine Bacterium Thalassotalea sp. However, electrophysiologic study revealed electrical substrate of ventricular tachycardia which could be ablated with pacemapping and substrate mapping. As DNA testing continues to expand proportionately to the increasing ability to detect genetic variations, ethical and fiscal concerns arise.

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Cognitive and demographic variables of a series of cases at the Royal Ottawa Hospital Preschool Program were examined. Histologic examination of the liver, kidneys, spleen, and mesenteric lymph nodes was performed after necropsy. Autoantibodies against MSD are formed during an acute infection with EBV. The aspartic acid, glutamic acid, and gamma-aminobutyric acid (GABA) contents were determined in four central auditory system regions in rats with transient neonatal hypothyroidism compared with control ones: the ventral and dorsal parts of the cochlear nucleus, the central nucleus of the inferior colliculus, the auditory cortex, and in an extra-auditory structure, the substantia nigra pars reticulata.

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This difference in efficacy is probably due to the higher affinity of FPL 12495AA compared to dizocilpine at the veratridine-binding site on the sodium channel. Eight middle-aged (42-59 years) overweight (body mass index 26.1-33.8 kg/m2) but otherwise healthy men were studied.

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The complications of dentinogenesis imperfecta are difficult to manage and provide a challenge to the dentist. We discuss the effect of seizure on expression of cytokines and growth factors, and explore the regulation of seizure development and aftermath by exogenous application or antagonist perturbation of these proteins. The autonomic pupillary changes in type I and II diabetic patients without clinical evidence of diabetic autonomic neuropathy (DAN) were compared with age matched controls. E1 consisted of a doublet of glycoproteins which varied in size from 51K to 56K between the three strains tested. Characterization of a hemagglutinin-specific inhibitor of influenza A virus.

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The clinical differential diagnosis of intravenous pyogenic granuloma is varied and requires careful pathologic attention if excised. Fetal Yap1 inactivation caused marked, lethal myocardial hypoplasia and decreased cardiomyocyte proliferation, whereas fetal activation of YAP1 stimulated cardiomyocyte proliferation. The status of child morbidity studies in the German Democratic Republic

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This may account for histologic findings of graft incorporation in experimental and retrieved specimens reported by other authors. Escherichia coli that produce heat-stable enterotoxin are a worldwide cause of diarrheal disease, especially in children.

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Influenza and pneumococcal vaccinations are recommended in chronic obstructive pulmonary disease patients to decrease associated risks at all stages. These findings profoundly affect our understanding of trisomy 21 as they suggest that virtually all maternal non-disjunction results from events occurring in meiosis I. Because automatic external defibrillator size and cost are directly affected by defibrillation waveform shape and because of the favorable experience with truncated biphasic waveforms in implantable cardioverter-defibrillators, we compared the efficacy of a truncated biphasic waveform with that of a standard damped sine monophasic waveform for transthoracic defibrillation. For subunit vaccine development, the glycoproteins were produced in both prokaryotic and eukaryotic expression systems.

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Based on a statistical analysis aimed at establishing whether Bt-maize varieties are equivalent to their near-isogenic counterparts, we discuss the limitations of using field experiments to assess the effects of Bt-maize on these two beetle families. Use of the laboratory in prediction of outcome in the high-risk newborn.

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Long-term effectiveness of anti-smoking counseling in primary care: the relapse process This diagnosis can be made with clinical, radiological and pathological criteria.

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Reducing stem length produced humeral stresses that more closely matched the intact stress distribution in proximal cortical bone. The taste and acceptability of the oral suspension form of azithromycin vs. Using a simple stochastic model of cancer recurrence derived within the random minima framework, we obtain parametric estimates of both the time-to-recurrence distribution and the probability of false-negative diagnosis.

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Hepatotoxicity of 9-nitrophenanthrene, and protection against it by beta-naphthoflavone. After 10 Gy radiation exposure, the p53 signaling pathway played an important role in TK6, whereas the NFkB signaling pathway appeared to replace the role of p53 in WTK1. These results support similar findings that a lifetime diagnosis of CFS is strongly associated with both lifetime PTSD and current traumatic symptoms, although familial factors, such as shared genetic and environmental contributions, played a limited role in the relationship between CFS, PTSD, and traumatic symptoms. 17 beta-estradiol increases calcium content in fetal mouse parietal bones cultured in serum-free medium only at physiological concentrations. We report a 14-year-old girl who developed epilepsia partialis continua involving the left hand, mild hemiparesis, and secondarily generalized seizures.

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The cells of the second type were most sensitive to stimulus movements at high velocities (fast cells) and had integration times of 20-40 ms. Demonstration of anti domestic dust serum entizol information assurance antibodies in atopic patterns. Two of these substances, which are present in the follicular fluid, are responsible for maintaining the meiotic arrest: cyclic AMP and purines.

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The quality of evidence was evaluated according to the Grading of Recommendations Assessment, Development and Evaluation approach. Effects of polymorphisms identified in genome-wide association studies of never-smoking females on the prognosis of non-small cell lung cancer. Drug withdrawal also precipitated a transient polypen im darm symptomen slokdarmkanker increase in the incidence of facial tremor and teeth chattering, but had no effect on yawning. In contrast to the previously studied structures, the gap between the slabs and the metal stripe and the associated field enhancement effect result in the dramatically modified modal behavior.

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Shape selective recognition of T.A base pairs lansoprazole odt 30 mg by hairpin polyamides containing N-terminal 3-methoxy (and 3-chloro) thiophene residues. As yet, the nature of the 54,000-57,000 and 68,000-75,000 dalton binding proteins identified by cross-linking studies are not known. We describe the management and clinical course in six patients with RCC who developed ISCM. Evaluation of 75Br-labelled butyrophenone neuroleptics for imaging cerebral dopaminergic receptor areas using positron emission tomography. Coding of odor intensity in a steady-state deterministic model of an olfactory receptor neuron.

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To evaluate the efficacy and safety of gemcitabine in combination with vinorelbine in elderly patients with anthracycline- and taxane-pretreated metastatic breast cancer (MBC). The purpose of this study was to determine whether the G2m(n), G1m(f) and Km(3) immunoglobulin allotypes have any association with susceptibility to invasive Haemophilus influenzae type b (Hib) and Staphylococcus aureus (S. Video-assisted thoracoscopic surgery (VATS) for the treatment of hepatic hydrothorax: report of twelve cases. Basal indirect or direct hemodynamic measurements showed no differences among the groups whereas under acyclovir topical cream cost pharmacological stress, only the group that received cells expressing VEGF showed a significant reduction in end-diastolic pressure and improvement in stroke volume and cardiac work.

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In spite of extensive efforts undertaken during the last decades, there is still no generally recognized explanation of the origin and primary pathological changes leading to AD development. Induction of cross clade reactive specific antibodies in mice by tecta drug monograph example conjugates of HGP-30 (peptide analog of HIV-1(SF2) p17) and peptide segments of human beta-2-microglobulin or MHC II beta chain. In CT, differential TGF-alpha immunostaining was noted between the villous and nonvillous CT.

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The antibacterial activity of baking soda (sodium bicarbonate) was assessed using three different experimental approaches. Contrary to existing radiologic/surgical data, thoracic duct dilation is not seen in all patients with hepatic cirrhosis and portal hypertension signifying advanced disease. Multi-shelled Dendritic Mesoporous Organosilica Hollow Spheres: Roles of Composition and Architecture in Cancer acyclovir dosage and treatment for herpes Immunotherapy. This mass confusion was solved by the report of the Hepatic Encephalopathy Consensus Group at the World Congress of Gastroenterology in 1998. The mammographic examinations, clinical presentation, and pathologic findings were retrospectively reviewed in 18 patients who underwent breast augmentation with silicone gel-filled implants.

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We examined the recombinant rabbit TIMP-1 expression in Escherichia coli using the pTrxFus expression system and the synthesis of the resulting soluble protein was confirmed by immunostaining with anti-TIMP-1. Responses from 118 questeionnaires from four groups of respondents revealed that 25 competency items met the criteria established for a core competency. Then, this metabolic derivative is further agopton 30 mg kapselnet metabolized, releasing its nitro group as nitrite.

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