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Spiractin (Spironolactone)

Spiractin is used to treat high blood pressure and heart failure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It is also used to treat swelling (edema) caused by certain conditions (such as heart failure, liver disease) by removing excess fluid and improving symptoms such as breathing problems. Spiractin is also used to treat low potassium levels and conditions in which the body is making too much of a natural chemical (aldosterone). Spiractin is known as a "water pill" (potassium-sparing diuretic). Spiractin has also been used to treat excessive hair growth (hirsutism) in women with polycystic ovary disease.

Other names for this medication:
Spironolactone, Aldactone, Aldactazide, Aldactazine, Aldazida, Aldazide, Aldozone, Alexan, Alizar, Carpiaton, Espirone, Espironolactona, Expal, Kespirona, Lanx, Letonal, Osiren, Osyrol, Practon, Prilactone, Spiractin, Spiresis, Spirix, Spiroctan, Spirolang, Spirolon, Spiron, Spirono, Spironolacton, Spironolactona, Spironolakton, Spironolattone, Spirotone, Verospiron, Xenalon,

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Homocysteine-induced decrease in endothelin-1 production is initiated at the extracellular level and involves oxidative products. Lectin-mediated drug delivery: binding and uptake of BSA-WGA conjugates using the Caco-2 model. These observations were specific for ICP8 since the heterologous Escherichia coli single-strand DNA-binding protein could not substitute for ICP8.

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The information written by the g-CNQDs is invisible in ambient light and UV light, but it can be readable by a fluorescence microplate reader. To assess the feasibility of nerve sparing radical hysterectomy (NSRH) technique and the impact on the improvement of postoperative bladder function in patients with cervical cancer. Similarly, enzyme activity in saliva was assessed using zymography. Gastroclysis by drops in the rehydration in septic enteritis of the newborn infant The program was applied to the design of ligands for the enzymes elastase, renin and thermolysin.

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This type of lymphoma, in contrast to body cavity-based lymphoma related to the acquired immunodeficiency syndrome, may have an indolent clinical course. A few labeled terminals were seen in the dorsolateral protuberance of the medial nucleus, and in the anterior interpositus and the posterior interpositus nuclei. None of our observers changed strategy as a function of separation or size. The authors report a case of foot trauma produced by a piece of the lawn mower blade, which was fired projectile-wise from the machine while it was in operation. Although traditional polysaccharide pneumococcal vaccines have been in use since the 1980s, and are effective among certain age groups, they do not provide protection to children under the age of two years who are at highest risk of infection from pneumococcal disease.

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While neutrophil (PMN) influx is characteristic of the acute phase of peritoneal infection, significant mononuclear cell (MNC) infiltration, occurs throughout the whole period of infection. Fluid accumulation started within 1 h after the inoculation of toxin and was maximal after 5 h, whereafter recovery gradually ensued. Formation of inositol triphosphate in lymphocytes of rat spleen in the early stages after x-irradiation by the formation of Pt-DNA adducts) or by the downstream biological consequences of that damage. To determine the actual in vivo loading environment of an elastic interlaminar-interspinous implant (Coflex).

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10Sa RNA complements the temperature-sensitive phenotype caused by a mutation in the phosphoribosyl pyrophosphate synthetase (prs) gene in Escherichia coli. To evaluate the shaping ability of hand-used ProTaper on curved canals using Endodontic Cube. Screening for HIV-1 infection targeted to women at a center for sexually transmitted diseases (STD). Some of the difficulties encountered in investigations of long-term drug nephrotoxicity are reviewed, and the evidence for acute and chronic renal damage induced by aspirin is discussed. We modeled the range shift of two ecologically distinct Vincetoxicum species using the species distribution model (SDM) and assessed the genetic consequences of secondary contact by combining morphological and genetic approaches.

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Acute lymphoblastic leukemia in persons over the age of 30 yr in the middle east. Alkaline DNase activity appeared 1 hr after vitamin administration, decreased slightly until 2 hr, and disappeared by 8 hr after treatment.

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The aim of the present study was to determine whether hexabromocyclododecane (HBCD) or 4-nonylphenol (NP) may induce prostatic cancer progression in LNCaP cells. Risk assessment and risk-based therapeutic strategies in febrile neutropenia. The sequence of a large cDNA fragment of proenkephalin-A from the cat adrenal medulla was obtained using reverse transcription followed by polymerase chain reaction, and cloning.

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These data indicate that cognitive impairments and negative symptoms are related, but discriminable, features in schizophrenia and that the considerable overlap between some negative symptoms and estimates of cognitive function may suggest a rethinking of the definition of some of these symptoms. An experimental model of retinal pigment epithelial and neurosensory serous detachment. The ability of several growth factors to reverse heparin-induced inhibition of rat glomerular epithelial cell (GEC) growth and the mechanism of growth inhibition were explored in vitro. Specific and nonspecific components in the neurohumoral link of the conditioned food-refusal reflex in the edible snail Central hemodynamics based on rheoencephalographic data in elevated arterial pressure in man

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The main obstacles to greater use of soy protein in the therapy of hyperlipidemia include lack of knowledge by physicians and patients of its effects and lack of availability of easily used products. These results suggest that the group trend toward disproportionate nonverbal/visual, as opposed to verbal, age-related memory differences is not associated with a group trend toward disproportionate enlargement of the right ventricle. Several recent reports have documented the neuroinvasiveness of human herpesvirus-6 (HHV-6) in infants with primary HHV-6 infections, in children and adults with AIDS, in recipients of bone marrow transplants, and in immunologically intact adults and children.

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Sequence determination showed that the mature BmK AGP-SYPU2 peptide is composed of 66 amino acid residues, and BmK AGP-SYPU2 is identical to BmK alpha2 (GenBank Acc. Yield of amino acid precursors by photons greatly depended on their wavelength. Allogeneic non-myeloablative stem cell transplantation for the patients with heavily pre-treated refractory lymphoma. Patterns of referral of retinal patients for low vision intervention in the anti-VEGF era.

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Almost all patients with subacute skin lesions were bimorphic or trimorphic, which might be due to genetic or racial differences between Japanese and other populations. Surprisingly, we found that IL-4 up-regulated the histone acetyltransferase activity of CREB-binding protein (CBP)/p300, which is responsible for acetylation of nuclear histones and STAT6. Transcriptional regulation of subunit-9 genes was found to be altered in Batten disease.

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The principal aims of this study were as follows: 1) to validate the utility of detecting p53 gene mutations by means of polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) analysis of complementary DNA (cDNA) (synthesized from prostate tissue RNA and 2) to study the concordance of RNA- and DNA-based PCR-SSCP assays in detecting p53 mutations in individual tumor fragments. Antibody-dependent cell-mediated cytotoxicity (ADCC) has been considered to be one of the main effector mechanisms by which unconjugated monoclonal antibody (mAb) 17-1A can exert an antitumor effect in vivo. Our results suggest a role for Bcl-xL in the regulation of apoptosis by EGF and TGF beta in mammary epithelial cells.

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The intracellular GSSG level was maintained at saturation for transport (7.5 nmol GSSG X min-1 X g heart-1) by continuous perfusion with 20 microM t-butyl hydroperoxide. We conclude that inhibition of DPP IV is a feasible approach to the treatment of type 2 diabetes in the early stage of the disease. Previous studies have shown higher survival rates for participants in trials of cancer therapy. CVS reduced the incidence of indigenous infections and this effect was attributable to the acceleration of recovery from 5FU-induced myelosuppression. Practical aspects of roadside tests for administrative traffic offences in Germany.

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Clinicians and researchers are beginning to acknowledge the importance of integrating a developmental perspective into the understanding of clinical disorders. We report a man with a ruptured intracranial dermoid cyst, suffering from headache, nausea, vomiting and a generalised seizure. Programs to increase the rate of delivery of these interventions in clinical practice have not been widely implemented. If the lasers have a frequency difference equal to the electron plasma frequency, they can drive a large amplitude plasma wave. The number of heart muscle and connective tissue cell nuclei was correlated with myocardial weight.

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Role of posture in mechanics of the lumbar spine in compression. One of most important clinical applications of molecular oncology in near future in our country is diagnosis of hereditary cancer. The results obtained should facilitate the design of improved vaccine candidates using this antigen delivery technology. This paper links up with Part I and deals with the other medicinal preparations, which were originally included in the Austrian book of prescriptions Dispensatorium pharmaceuticum Viennense and then taken over to the Austrian provincial pharmacopoeia Pharmacopoea austriaco-provincialis, repeatedly published between 1774 and 1794.

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Lateral and medial septal lesions reduce anxiety in the plus-maze and probe-burying tests. Here, we assessed whether such patients also displayed an immunoglobulin deficiency and if this condition contributed to infection proneness. Although physical methods of cooling are the treatment of choice for hyperthermia, their value in the treatment of fever remains uncertain. Our conclusion from this observation is that a specificity factor is involved in the activity of these short peptides.

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Depending on the growth sugar, the presence of xylitol resulted in the selection of xylitol-resistant populations for several of the six strains tested, but not necessarily in the presence of all four sugars. Phospholipids were also higher in the plasma of ethanol-fed animals when compared to controls so that the plasma cholesterol/phospholipid ratio (Ch/PL ratio) of the two groups did not differ significantly, regardless of the cholesterol fraction considered. The promoter activities of human and mouse tie were analyzed using luciferase reporter gene constructs in transfected cell lines and beta-galactosidase constructs in transgenic mice.

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No significant cytotoxic effect on mammalian cells was observed at bacteriotoxic concentrations of SkQ1. Hu proteins, together with neurone-specific enolase (NSE), protein gene product 9.5 (PGP-9.5), microtubule-associated protein-2 (MAP-2) and tubulin beta III isoform, were evaluated immunohistochemically as neuronal markers in whole-mount preparations and cultures obtained from the myenteric plexus of guinea-pig small intestine. The best-corrected visual acuity (BCVA) and central macular thickness (CMT) on optical coherence tomography were measured at baseline and postoperatively with a minimum follow-up period of 12 months. Biphasic changes in mouse motor activity during exposure to toluene.

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Nonlinear conjugation metabolic rate of valproic acid (VPA) has been speculated previously from plasma elimination and liver concentration of VPA in guinea pigs. For example, with planar platforms based on lithographically-prepared pillar arrays, the size, shape, height, geometric arrangement, and inter pillar gaps can be independently adjusted. The present experiments altogether give support to the concept that serum factors as exogenous stimuli are necessary not only for cell growth but also for the probably closely interrelated development of the microtubule-microfilament system needed e.g. Abstracts from the 2nd International Conference on Chromosome 21 and Medical Research on Down Syndrome: Part 2.

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Additional chromosome aberrations in acute promyelocytic leukemia: characteristics and prognostic influence. Using quantitative-competitive PCR for the quantification of FH-specific mRNA, its constitutive rate of synthesis was found to be nearly ten times higher in KC than in HC. Both were human immuno-deficiency virus negative and no other causes for elevated immunoglobulin E were found.

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No genotypic differences were observed in non-dependent mice, discounting possible differences in basal naloxone sensitivity and/or opioid peptide levels. Space, the final frontier: A critical review of recent experiments performed in microgravity. We report that PTHrP protects these cells from doxorubicin-induced apoptosis and promotes anchorage-independent cell growth via an intracrine pathway.

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This migratory stream reaches the anterior pole of the pons by day E18. Given the critical role of AA in signaling linked to G protein-coupled receptors (GPCRs), these observations provide a mechanism for cross talk between GPCRs linked to phospholipases and the tyrosine kinase receptor signaling cascades. Diagnosis and treatment of the acute porphyrias: an interdisciplinary challenge. All of these features were lost in mesengenic terminally differentiated P2-MSCs, showing definite separation of the two differentiation lineages. The molecular pharmacology of CGRP and related peptide receptor subtypes.

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The beta class is by far the most predominant species and has been further characterized. We used the freeze-fracture technique to better evaluate myelin alterations during an early stage of Wallerian degeneration. Retrospective analysis of prostate cancer recurrence potential with tissue metabolomic profiles. Consequently, the findings may illustrate the close association between the coagulation system and inflammatory reactions which may be common to most pleural diseases.

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Bone marrow microvessel density is a prognostic factor for survival in patients with multiple myeloma. Considerable case to case and cell to cell variations, however, were noted in the expression of lectin binding activity. Study on the adsorption of collagen onto surfaces with imaging ellipsometry

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Recent discoveries of indisputable early fossil snakes with posterior legs are generating intense debate about the evolutionary origin of these reptiles. A refugee acculturative stress inventory modified to fit this group was utilized, and Pearson correlation and t-test were employed for statistical analysis. Importantly, the trend was observed regardless of the expression breadth of the nearby gene, indicating that slow evolution of housekeeping genes was not the major reason for the correlation. In experiment 1 no differences in methionine adenosyltransferase (MAT) or cystathionine lambda-lyase (CGL) were detected between lucerne and wheaten straw diets, or between effects of fasting for 48 h and 96 h after feeding lucrene chaff as opposed to fasting after feeding wheaten straw. This investigation highlighted existential well-being as an important factor associated with lower levels of suicidal ideation among college students.

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Contrast volume is the primary physician modifiable risk factor for prevention of contrast-induced acute kidney injury CI-AKI which is a frequent complication in patients undergoing coronary angiographic procedures and is related to increases in morbidity, mortality, and healthcare costs. Significant decreases in urine formation by angiotensin II were observed, even in the presence of saralasin. Corpora lutea (CL) were collected from mares during early (Day 4-5), mid- (Day 8-9), and late (Day 12-13) dioestrus.

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Studies on the pharmacokinetics of hexylcaine hydrochloride in man and the mouse. Shots were made with a Russian AK-74 assault rifle (5.45 mm) into gelatin used as a tissue simulant. Continuous intraventricular pressure recording disclosed frequent acute transient rises of intracranial pressure resembling the plateau waves as described by Lundberg despite a low basic level of intracranial pressure. A total of 5 dominant cataract mutations, 3 dominant cataract mutation mosaics, 1 specific-locus mutation and 9 specific-locus mutation mosaics were recovered in 15,542 screened F1 offspring.

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Although there were no significant differences in global alcoholism scores, a subgroup of bulimics emerged for whom bulimia was one of multiple and debilitating addictions. The aim of the present study was to identify the source of peri-implant colonization by periodontopathic bacteria.

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To estimate the prevalence of, and factors associated with, abnormal serum cholinesterase (SChE) levels among chilli-farm workers in Chatturat District, Chaiyaphum Province. In order that patients may be served properly, the smile must be understood, recorded, and analyzed so that desirable aspects may be preserved and graceless components returned to attractiveness. We measured threshold versus intensity curves to determine which combination provided (a) the greatest isolation of the short-wavelength sensitive mechanisms and (b) the largest dynamic range for perimetry.

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Importance of glutamine for gamma-aminobutyric acid synthesis in rat neostriatum in vivo. Treatment with penicillin G and hydrocortisone reduces ALS-associated symptoms: a case series of three patients.

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Activation of the renin-angiotensin-aldosterone system (RAAS) is common in obesity. Besides aiding with clinical varicocele detection and management, clinical practice opinion statements and guidelines aim to direct and strengthen the infrastructure of future studies. Southern blot analysis of genomic DNA from 17 independent mouse-human somatic cell hybrids demonstrated the presence of the gene for human lipoprotein lipase on chromosome 8, whereas the gene for hepatic lipase was on chromosome 15. Because equal orders are suggested in the literature, a fourth-order Legendre polynomial is venlafaxine and alcohol interaction with metronidazole recommended in this study. Physical activity in a probabilistic sample in the city of Rio de Janeiro

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A retrospective study was carried out with 71 participating general practitioners. The basolateral sorting signal of the polymeric immunoglobulin receptor contains two functional domains. As in analogous experiments retin-a gel 0.025 clindamycin phosphate on dimensional transfer in rats and monkeys, performance in the second problem was more accurate when the relevant and irrelevant dimensions were the same as in the first problem than when they were interchanged.

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