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The synthesis of dihydrotestosterone (DHT) is catalyzed by steroid 5alpha-reductase isozymes 1 and 2, and this function determines the development of the male phenotype during embriogenesis and the growth of androgen sensitive tissues during puberty. The conjugate was both colloidally and chemically stable in phosphate buffered solutions and could be used as a probe for magnetic resonance and fluorescent imaging. Gross inspection of resected tissue confirmed yellowish-white, solid tumor mainly circumferentially encompassing the lumina of the cricoid ring. Tec, the prototypical member of the Tec family of tyrosine kinases, is abundantly expressed in T cells and other hemopoietic cell types. To develop enzyme forms with reduced glutaminase activity, a number of variants with amino acid replacements in the vicinity of the substrate binding site were constructed and assayed for their kinetic and stability properties.

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Intracardiac thrombi associated with antiphospholipid antibodies. The precise physiopathology is currently unknown in both conditions, but a delayed hypersensitivity mechanism is likely. IgA nephropathy and tubular proteinuria in a patient with congenital solitary kidney. Evaluation of the efficacy of oral cromolyn sodium or an oligoantigenic diet in children with atopic dermatitis: a multicenter study of 1085 patients.

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This deficiency leads to storage of abnormal glycogen (polyglucosan bodies) in the liver and other tissues. To compare peak oxygen consumption (VO2peak) and skeletal muscle oxidative metabolism between nine African-American and nine Caucasian men.

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GARS is ubiquitously expressed and may have functions in addition to its canonical role in protein synthesis through catalyzing the addition of glycine to cognate tRNAs. The heterochronic gene lin-29 encodes a zinc finger protein that controls a terminal differentiation event in Caenorhabditis elegans.

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Seminar on pathology, clinical medicine and surgical technique: fibrolipoma and osteomas of the finger A review and a discussion of the cause of this deformity were presented.

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Moreover, using this system we demonstrate a time-dependent effect of electrical stimulation in reducing the severity of various indices of motor hyperactivity associated with abrupt morphine withdrawal in rats. Antimicrobial susceptibility testing for feline urinary tract isolates.

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Peptide deformylase catalyzes the removal of the N-terminal formyl group from nascent polypeptides during prokaryotic protein maturation and is essential for bacterial survival. An unusual association: sick sinus syndrome and congenital cataract in a 6-month-old girl. Our findings refute the hypothesis that in ischemic acute renal failure exposure to complement-activating cellulosic dialysis membranes impairs the recovery of renal function. As a result, we show that simple dynamics like the transformation of a soliton of an unstable branch into a soliton of a stable branch can also be predicted from the H-Q diagram.

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A human genomic DNA library was screened by in situ hybridization. In the course of that dream, since a fetus does not breathe (in the usual sense) the infant may cease to breathe and may die. Following short exposure to oral prednisone, both boys developed lethargy, increasing somnolence, polydipsia, polyphagia, and polyuria.

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Patients with irritable bowel syndrome show selective hypersensitivity of intestinal mechanosensitive pathways associated with a nonspecific, probably central dysfunction of viscerosomatic referral. Immunohistochemical detection of Ki-67 in epithelial skin tumors in formalin-fixed paraffin-embedded tissue sections using a new monoclonal antibody (MIB-1).

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Consequences of a false-positive mammography result: drug consumption before and after screening. The estimated prevalence of CML is approximately 70,000 in 2010, 112,000 in 2020, 144,000 in 2030, 167,000 in 2040, and 181,000 in 2050, when it will reach a near plateau prevalence. The expected cost analysis and cost-effectiveness analysis were also performed. Here, we present the detailed step-by-step methods for the real-time observation of G-rich DNA sequences by means of single-molecule FRET microscopy and provide the protocols for vesicle encapsulation and surface immobilization assays.

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Possible application of Allium phytoncides and of gramicidin in gangrene of the pulp Thus, NKT cells and IL-13, possibly produced by NKT cells and signaling through the IL-4R-STAT6 pathway, are necessary for down-regulation of tumor immunosurveillance. Training in the specialty of forensic psychiatry is in flux, but existing standards provide interesting insight into the field. The staged TCPC was a good procedure in high-risk Fontan candidates.

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Bleomycin sulfate in the treatment of mosaic plantar verrucae: a follow-up study. Latent class models allow for alternative characterization of NSES for use in studies of cancer causes and control. The program MRBAYES performs Bayesian inference of phylogeny using a variant of Markov chain Monte Carlo. Amphetamine-induced turning behavior in these rats was reversed by the transplants after 1.5-4.5 months. TPN failed to improve relevant biochemical markers and clinical outcome after laparotomy for peritonitis.

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Immunofluorescence microscopy revealed C3c deposits with immunoglobulins along the glomerular capillary walls and in the walls of small arteries and arterioles. On lateral 1/4 region, lateral-middle 1/4 region, medial-middle 1/4 region and medial 1/4 region, screw posterior column angle is 40 degrees to 60 degrees , 60 degrees to 75 degrees , 75 degrees to 90 degrees , 90 degrees to parallel to the quadrilateral plate, and the length of the screw is 30 mm. In vitro data suggest that there are complex pathways of angiotensin production and that multiple receptor subtypes mediate the actions of this peptide.

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The corpus callosum (CC) is a midline white matter brain region that is important in interhemispheric communication and coordination. In all, locally isolated strains from thirty hosts studied, the minimal inhibitory concentration (MIC) for dehydroemetine ranged from 0.125 to 1 microgram/ml, ornidazole ranged from 0.0625 to 0.25 microgram/ml, metronidazole ranged from 0.0625 to 0.125 microgram/ml, and tinidazole ranged from 0.0625 microgram/ml to 0.25 microgram/ml.

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As a result of this increased awareness, Latin American hydrogeologists and environmental regulators have been able to recognize the potential problems that could result from DNAPL spills that may impact groundwater and have learned to approach them using locally available technology and resources. Self-reports of salt intake by 10- to 18-year-olds: relationship to urinary sodium excretion. Since repair activity of MYH protein on an A:G mismatch has also been reported, we compared the repair activity of His(6)-tagged MYH proteins, expressed in Spodoptera frugiperda Sf21 cells, on A:oh(8)G and A:G mismatches by DNA cleavage assay and gel mobility shift assay. Structure and Function of the Two-Component Cytotoxins of Staphylococcus aureus - Learnings for Designing Novel Therapeutics.

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This prospective, randomized study aimed to compare the analgesic effects of acetaminophen, diclofenac and hyoscine-N-butylbromide (HnBB) in cases of second trimester pregnancy termination. Astigmatism correction: Laser in situ keratomileusis versus posterior chamber collagen copolymer toric phakic intraocular lens implantation.

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Double-labeling experiments showed strong expression of the CMV Fc gammaR in a perinuclear region of infected cells but not in bystander uninfected cells. Metabolic basis for the protective effect of the antioxidant ethoxyquin on aflatoxin B1 hepatocarcinogenesis in the rat.

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The effects of radiation on the heart have been well described including acute and chronic pericarditis, myocardial fibrosis, accelerated arteriosclerosis of the coronary arteries. (Digenea: Acanthocolpidae) from Seriola hippos (Perciformes: Carangidae), Western Australia, with some observations on the relationships in the genus.

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Engineering metal (hydr)oxide sorbents for removal of arsenate and similar weak-acid oxyanion contaminants: A critical review with emphasis on factors governing sorption processes. As judged from the results of alkaline phosphatase digestion, these charge variants represent differently phosphorylated forms.

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Many children hospitalized with serious bacterial infections are candidates for either home oral antibiotic therapy or outpatient parenteral antibiotic therapy. This mutation did not appear to affect the conformation of the domain nor the pattern of expression of E-cadherin on the cell surface. Interaction between Chlamydia trachomatis BU-34 strain, L2 serovar and human spermatozoa in vitro was studied by electron microscopy.

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The presence of lower extremity arterial occlusive disease is an important, independent predictor of in-hospital mortality rates for patients undergoing CABG. Weak associations were found between family of origin dysfunction and poorer general quality of childhood memory, but the study as a whole resulted in few significant findings. Higher levels of p21(WAF1/CIP1) were detected in lysates from IFNalpha-treated U-373MG cells as compared to media controls for as long as 18 h. Variations of angiotensin converting enzyme in chronic obstructive pulmonary disease and chronic respiratory insufficiency

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Therefore, it is unlikely that tachycardia is a major stimulus for secretion of ANP during exercise. Cryotherapy, a surgical procedure often performed on ROP patients, is reviewed and compared to photocoagulation, a form of laser therapy.

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Transient splenic accumulation of Tc-99m HMDP caused by megaloblastic anemia. Studies reporting outcomes of robotic colorectal surgery were identified by systematic searches of electronic databases. Maturational changes of mast cells from the first day of birth to maturity of animal and during the oestrous cycle have also been determined. China National Nutrition and Health Survey 2010-2013(CHNNS2010-2013) is a nationally representative cross-sectional study. However, these were found not to be suitable for the measurement of grip force and force modulations during precision grip independently from the hand orientation.

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Histopathology of the lung and total IgE in serum were compared in toxocariasis and allergic asthma murine models using BALB/c and C57BL/6 mice. Using the formula of the coherent second order optical process which consists of the excitation process from the 2p core state to the empty 5d state and of the radiative decay from the 3d core state to the 2p core hole, we calculate RXES-MCD spectra. Pharmacological characterization of P2 purinoceptor types in rat locus coeruleus neurons. Sample infection control needs assessment survey data from eight countries.

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Localization of a domain in apolipoprotein E with both cytostatic and cytotoxic activity. This identifies the Hd mutation as a useful model for the examination of homeo box expression during mammalian development. Concomitant determinations of plasma concentrations of the main metabolite of dipotassium clorazepate and diazepam, desmethyldiazepam, showed no statistical difference during treatment, suggesting that the developed tolerance was not metabolic but functional. Typical leucocytoclastic vasculitis with red blood cell extravasation developed by 24 h.

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We observed a significant increase of TIMP-1 expression in neointimal SMCs at both nucleic acid and protein levels, suggesting a role of TIMP-1 in injury-induced atherogenesis. Histochemical study revealed severe anatomic disruption of the cochlear and vestibular end organs, suggesting that Kvlqt1 is essential for normal development of the inner ear. Major upper gastrointestinal haemorrhage associated with hepatic arterial chemoperfusion. bNP-I differs from bovine neurophysin-II, the second major neurophysin of cow, in 20 residue positions, and several of the differences cannot be accounted for by single nucleotide replacements in the genes coding for these two neurophysin proteins.

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We expect the present algorithm will be very useful for modeling electrochemical problems in the future. It appears that the outcome in these patients depends on the gravity of preoperative deficits, whereas the survival is influenced by the type of treatment. Other abnormalities such as increased sialylation or fucosylation have also been detected.

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In addition, immunoreactivity for type IV collagen was detected as a discontinuous line along the basement membranes of ducts, vessels, tubular complexes, and acinar cells. A matched series of 178 fertile women were used as a control group.

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To assess the effect of TNF-alpha exposure on mucin secretion, human airway organ cultures and primary cultures of human airway epithelial cells were stimulated with 20 ng/ml of recombinant human TNF-alpha and mucin secretion quantitated by an enzyme-linked immunosorbent assay using a specific monoclonal antibody directed against human airway mucin. All patients exhibited bilateral, glistening yellow-white crystalline deposits that were located in the innermost retinal layers and appeared during the first 2 years of life.

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Areas of postcontrast leptomeningeal enhancement were identified. The development of antibiotics might have had an important role in the variation of stone compositions.

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Malarial hemozoin may play an important role as a target for antimalarial drugs and in disease pathogenesis. Histological effects of androgen deprivation on the adult chimpanzee epididymis. Progress during the last twenty years in the radiological diagnosis of gastric cancer Chloroplast Hsp70 Isoform Is Required for Age-Dependent Tissue Preference of Bamboo mosaic virus in Mature Nicotiana benthamiana Leaves.

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Clear evidence for a T(3/2) law is found over a wide temperature regime. Meiosis in Gymnosporangium and the cytological effects of certain antibiotic substances. Pathologico-anatomic changes of empendyma and choriod plexus in tuberculosis meningitis treated with streptomycin An intelligent diagnostic system for the assessment of gestational age based on ultrasonic fetal head measurements.

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Aggregate efforts to reduce risk factors between 1981 and 1990 have led to substantial reductions in CHD and should be well worth the cost, largely because of population-wide changes in life-style and habits. pant general hospital, (associated hospitals of Government Medical College, Srinagar). The relationship between new stroke onset and serum thiocyanate as an indicator to cigarette smoking. Here we describe the identification of a regulatory circuit between muscle miRNAs (miR-1, miR-133 and miR-206) and Yin Yang 1 (YY1), an epigenetic repressor of skeletal myogenesis in mouse. Examination of the assumptions underlying research and educational resources on breast-feeding reveals bias and a lack of data to substantiate perceived facts.

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Islet cell autoimmunity and progression to insulin-dependent diabetes mellitus in genetically high- and low-risk siblings of diabetic children. Gay men with AIDS and their families of origin: an analysis of social support. Our results are in line with previous reports on nonleukopenic patients and suggest that the positive effects of pressure-limited mechanical ventilation are independent of circulating white blood cells. Cell subpopulations of pyelonephritis patients studied using monoclonal antibodies

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Concerted kinetic folding of a multidomain ribozyme with a disrupted loop-receptor interaction. Psychiatric and sociodemographic predictors of attrition in a longitudinal study: The Netherlands Mental Health Survey and Incidence Study (NEMESIS).

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The lesions invariably were more severe after the second inoculation. Altered endothelium-dependent responsiveness in the aortas and renal arteries of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus.

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The functions that operate following complex formation with cognate antigen involve binding to C1q (to mediate complement fixation) and the Fc receptors, Fc gamma RI, II and III. Antibody from chickens immunised with purified native flagellin protein recognised flagellin protein and the 67 Kd antigen in Western blots probed with serum, but only the flagellin proteins (61-63 Kd) in Westerns probed with gastrointestinal secretions. monocytogenes on viral replication, we observed an increase in rotavirus antigen synthesis but no significant effect on poliovirus yield under our experimental conditions. The aim of this study was to investigate the effect of aging on allergic pulmonary inflammation induced by epicutaneous sensitization of mechanically irritated skin in mice. Here we show, by inactivating the immunoglobulin tail tyrosine (ITT) signalling motif of membrane-bound IgG1 in the mouse, that the ITT facilitates maintenance and reactivation of IgG-switched memory B cells in vivo.

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Transcripts for the novel cytokine IL-15, which utilizes the beta and gamma chains of the IL2-R, have been found in melanoma cells and anti-IL-15 mAbs inhibit HLA class I expression in these cells. bronchoalveolar lavages (BAL) from patients affected by COPD, ultrasound treated human serum and cultured human lung endothelial cells challenged with elastase. Anti-tuberculosis drugs were administered to two patients unnecessarily, resulting in adverse drug reactions in one patient. The optomagnetic technology is fundamentally suited for high-performance integrated testing and is expected to open a new paradigm in biosensing. Satisfactory intraoperative conditions were obtained in all cases.

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There is a possibility that DI estimates a slight deformation of bone structure. In this review we discuss the typical patient presentation, the investigations that should be performed, the typical findings on various imaging modalities, and the treatment options of symptomatic patients with MoM hip arthroplasties. Using the Fourier transform on a peristimulus time histogram (PSTH) to calculate spectral components of a spike train can yield erroneous spectral amplitudes.

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Our data rather indicate that E-FABP expression is related to the commitment of keratinocyte differentiation and that the putative role of E-FABP should not be restricted to the formation of the skin lipid barrier. The findings are identical with those observed in the normal aging human lens. Meta-iodopsin II, the signalling state of iodopsin, decayed about 100 times faster than meta-rhodopsin II.

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The effective refractory period (ERP) is shortened with the increase in HR, but the shortning of ERP varies in different part of the cardiac conduction system. As a result of the developing ischemia, hypoxia has an important pathogenetical significance in disorders of circulation, inasmuch as it exerts influence not only on the nervous tissue, but on the capillaries leading to their dysfunction, an increase of the wall permeability and oedema. The ANOVA factors were anterior-posterior electrode location (F, FC, C, CP, P), left-right electrode location (left, middle, right) and task type (self items in the congruent and the incongruent conditions). The third patient died 1 year after the cancer was diagnosed because of metastases.

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Reports have been published on the identification of tumor cells with stem cells characteristics in different types of tumors (acute myelogenic leukemia, breast cancer, prostate cancer, bone sarcomas, liver cancer, and melanomas). This model was used to determine the temperature gradient in cortical bone in the absence of sensors. Comparative local and systemic immunization against experimentally-induced Bordetella bronchiseptica pneumonia in ICR mice The results are consistent with the topography of myenteric VIP neurons (which project into circular muscle) and somatostatin neurons (which project caudad within the plexus) and the pharmacological properties of the two peptides.