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Imda (Bicalutamide)

Imda is a new nonsteroidal antiandrogen developed for use in patients with prostate cancer. The efficacy and tolerability of Imda as monotherapy and as combination therapy for patients with advanced prostate cancer have been evaluated in randomized clinical trials. Clinical trials are currently in progress to further evaluate Imda as monotherapy in patients with advanced stages of disease and as adjuvant or first‐line therapy in patients with early‐stage disease.

Other names for this medication:
Bicalutamide, Casodex, Bicalox, Bicalutamida, Bicusan, Bidrostat, Caluran, Calutide, Calutol, Capro, Cosudex, Imda, Lutamidal, Probic, Zolacos,

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Correlation of dental-record medical histories with outpatient medical records. We found that in CeM neurons in which diazepam increased the inhibitory postsynaptic current (IPSC) decay time, TGOT (a specific oxytocin receptor agonist) increased IPSC frequency. These results show a relationship between antigens of both Pf and Pv and desmosomes, as well as heterogeneities of both Pv and Pf antigens in terms of antigenic molecules or epitopes. According to these studies significant relationships between abnormal Doppler findings and the following obstetrical problems were found: intrauterine growth retardation, preterm delivery, acidosis determined by fetal blood sampling, abnormal intrapartum fetal heart rate, neonatal depression and acidosis, and admission to neonatal intensive care unit. This correlational study examined the relationship between patient trust of nurses, level of postoperative pain, and discharge functional outcome following total knee arthroplasty.

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Involvement of protein kinase C and arachidonate signaling pathways in the alteration of proliferative response of senescent IMR-90 human fibroblasts. When a patient has a fracture dislocation of the shoulder joint associated with a swollen arm, compartment syndrome of the upper arm should be included as a differential diagnosis. One reviewer extracted data and assessed quality using the Downs and Black checklist. With the release of the short-chain fatty acids butyric or propionic acid during the hydrolysis of a structured triglyceride containing butyric acid (C4-L-C4-TG) or the beta-oxidation of nonanoic acid from trinonanoin (C9TG), respectively, the infusion of these two triglycerides was supposed to reveal positive effects against the TPN-induced atrophy of the intestine. This includes the rare repeats 3 and 4, which have been postulated to play a role in transcription regulation and to associate with alcohol abuse liability in humans.

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The analgesic effect of the composite of dynorphin/morphine was dose-dependent in serial dilutions and not accompanied by any signs of motor dysfunction. Treatment with 50 mg/kg of dextromethorphan reduced the increase in locomotor activity observed on day 1 and 3 after ischemia. Randomised, double-blind, placebo-controlled clinical trials of oral tenoxicam for relief of acute postoperative pain in adults. In this study, we investigated alteration in integrin expression on HepG2 cells, which follows the selectin-mediated initial adhesion of HepG2 cells to HUVECs.

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Anaesthetic agents alone are not sufficient to ablate the response to tracheal intubation, skin incision and sternotomy. A decreased amount of duodenal endocrine cells has recently been found in patients with familial amyloidotic polyneuropathy (FAP), and it has been suggested that this may contribute to the development of the gastrointestinal symptoms. The metabolic changes induced during differentiation of the 3T3-L1 cell line were then compared with the metabolic differences between pre- and postdifferentiation primary adipocytes. Lipoprotein lipase mRNA abundance in rat brown adipose tissue increases during the first 24 h of cold exposure.

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In conclusion, our results confirm diastolic abnormalities in rheumatoid patients and point out that these abnormalities also affect echo-Doppler parameters of left ventricular filling. Adopting prevention policies is most urgent for practices serving individuals at increased risk, such as African American women and women without prenatal care. Surprisingly, both site-directed mutation of putative consensus PKG phosphorylation sites and truncation of entire cytosolic NH(2)- and COOH-terminal tails did not alter the response to 8-pCPT-cGMP. Of 21 ovarian specimens obtained at term (36-42 weeks of gestation), decidual cells were confirmed in each. Using primary cultures of bovine granulosa cells the synergistic activation of oxytocin transcription by the cAMP pathway and stimulation of IGF-I or insulin receptors could be established.

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Surgical resection of the overgrowth depends heavily on the skill and experience of the surgeon. Eleven patients with recurrent post-liver transplantation disease, characterized by transaminase level abnormality and HCV RNA in serum and liver biopsy specimens consistent with HCV infection were offered enrollment onto the study.

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The mycobacteria isolated from the cerebrospinal fluid of both patients proved to be Mycobacterium bovis BCG. Experimental studies have shown 99mTc-teboroxime to have a higher first-pass myocardial extraction, exceeding that of 201Tl with nearly linear initial myocardial uptake over a wide range of coronary flows. These findings provide (i) further mechanistic insight into PHO5 mitotic activation, (ii) demonstrate that Mcm1-Fkh2 can function combinatorially with other activators to yield late M/G(1) induction, and (iii) couple the mitotic cell cycle progression machinery to cellular phosphate homeostasis. Startle response of human neck muscles sculpted by readiness to perform ballistic head movements. The number of embolized arteries, the volume and viscosity of embolic agent (Onyx), the number of additionally used coils, the embolization time, and the technical and clinical outcome were documented.

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The purification procedure of all isozymes included concanavalin A-Sepharose column chromatography. Efficacy of intracerebral delivery of cisplatin in combination with photon irradiation for treatment of brain tumors. Apart from a lower anaesthetic requirement and a reduced postoperative pain level after 30 min in the pre-incisional bupivacaine group, there was no difference between infiltration before (pre-emptive) or after surgery. As part of an effort to characterize this phenomenon, a solid-phase reagent was prepared by adsorbing human fibrinogen to polystyrene-divinylbenzene microparticles. Mycophenolate mofetil in renal allograft recipients: a pooled efficacy analysis of three randomized, double-blind, clinical studies in prevention of rejection.

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Dynamic changes in the dural sac cross-sectional area on axial loaded MR imaging: is there a difference between degenerative spondylolisthesis and spinal stenosis? In many cases the role of the pillars is to block or maintain fixed an interface between two immiscible fluids. A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line. Bursts of myoclonic activity were recorded from the rectus abdominis muscle and then from the external oblique muscle after a delay of 40 ms. Thus recent discoveries and better understanding of the penile anatomy had been meaningful in the development and improvement of specific nerve blockade techniques for penile surgeries in particularly adding up with acupuncture techniques, while minimizing anesthetic adverse effects and resulting in a rapid return to daily activity with minimal complications.

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The substitution of Arg for Gly2433 in the human skeletal muscle ryanodine receptor is associated with malignant hyperthermia. The effect of composite oral treatment for internal contamination with several radionuclides on 131I thyroid uptake in humans.

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These measurements were compared to a similar field of view of non-tattooed skin from an adjacent area. The temporary ischemia as experimental model for human shock lung.

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Pharmacological intervention with piperonyl butoxide inhibited TCDD-induced DNA degradation, restored the functional integrity of the medial yolk vein, and protected against the embryotoxicity of TCDD. Literature searches were conducted using MEDLINE, PubMed, and the abstract search engines for the American Society of Clinical Oncology and American Association for Cancer Research annual meetings (all searches through November 2008). Hereditary xerocytosis: a report of six unrelated Spanish families with leaky red cell syndrome and increased heat stability of the erythrocyte membrane.

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Physicians and death: comments and behaviour of 605 doctors in the north-east of Italy. Recent military experience suggests that transfusing fresh frozen plasma and packed red cells in a 1:1 ratio may improve survival in exsanguinating trauma patients.

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Sodium space and body sodium content, exchangeable with sodium24, in normal individuals and patients with ascites. Choroidal veins were very versatile in remodelling their structure and hemodynamics after sustained elevation of orbital venous pressure. The anti-fibrotic agent SMP-534 attenuates bleomycin-induced pulmonary fibrosis in hamsters.

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In this study, we investigated the effects of I3C in Her-2/neu over-expressing MDA-MB-435 breast cancer cells and compared these results with parental cells transfected with control vector. Selecting either EUS-FNA or TBNA as the first diagnostic procedure achieved a comparable diagnostic yield with significantly fewer procedures than performing TBNA first in all patients. Accordingly, a postpartum depression intervention program for married immigrant women should be developed and implemented. Serum creatinine, cholesterol and calcium concentrations showed no alterations.

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However, the rise in plasma glucagon concentration was sufficient to contribute to alimentary hyperglycaemia by promoting hepatic glycogenolysis in calves with abundant liver glycogen. Malacoplakia is a rare chronic inflammatory disease first described by von Hansemann in 1901. LAD, whose endogenous substrate was unknown, was recombinantly prepared and biochemically analyzed.

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This review casts a critical eye on the experimental evidence gathered to date and in particular questions the rationale for the current focus on components of the upstream IKK complex as therapeutic targets. Although EGF did not prevent the hepatotoxicity associated with TAA, it reduced mortality, renal injury, and gastrointestinal damage.

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To study the characteristics of the consumption of addictive substances by adolescents in Gabon. We measured the serum immunoglobulin G antibody titers against trehalose monomycolate (TMM-M) and apolar-glycopeptidolipid (GPL), lipid antigens extracted from MAC. Muscarinic agonists reduce tau phosphorylation in non-neuronal cells via GSK-3beta inhibition and in neurons. Patient education about lithium treatment should be intensified, especially for older patients taking lithium because adverse drug reactions pose a greater risk to the elderly.

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The pattern of use of various diagnostic and staging procedures for 1991 rural cases resembled that for urban men diagnosed with prostate cancer in 1986 rather than that for 1991 urban cases. MexXY, a drug efflux pump in Pseudomonas aeruginosa, confers resistance to aminoglycoside antibiotics. Collaborative work among regional, provincial, territorial, federal and international authorities within these domains is emerging as an effective response to the risk management of bioterrorism. In occupations requiring information presentation to workers, who are simultaneously performing a physical task, the visual modality appears most effective under high level exertion while haptic cueing degrades performance. Simultaneous Ni Doping at Atom Scale in Ceria and Assembling into Well-Defined Lotuslike Structure for Enhanced Catalytic Performance.

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Spontaneous exploration and AMPH-stimulated locomotor activity were examined on postnatal day 35 (PD35) and day 56 (PD56). In vitro DNA binding assays and transient transfection analysis with monkey kidney cells have implicated Nrl, a member of the Maf-Nrl subfamily of bZIP transcription factors, and the Nrl response element (NRE) in the regulation of rhodopsin expression.

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However, unlike conventional replicative transformants containing AMA1-bearing plasmids, these transformants are prone to spontaneous stabilization which occurs predominantly by conversion of the mutant chromosomal allele of the marker gene to the plasmid-borne allele. Irreversible differentiation of F9 cells was induced by 18 h of exposure to RA with subsequent incubation in the absence of RA. These results demonstrate that the technique is of potential clinical value to ophthalmologists and neurologists when subjective perimetry is not possible.

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Urine was enzymatically hydrolyzed, cleaned up on a C18 micro-column and the metabolites were identified by GC-MS using electron impact (70 eV) and chemical ionization with ammonia or isobutane as the reagent gas. A proximal segment of the corpora cavernosa was retained to reconstruct a clitoris. Quantification of dextromethorphan and metabolites: a dual phenotypic marker for cytochrome P450 3A4/5 and 2D6 activity. Therefore, we designed a left atrial model to examine the relation between PV flow direction and MR jet area. We report a relatively large and maturing experience with robotic radical cystectomy for the treatment of bladder cancer providing acceptable surgical and pathological outcomes.

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The DBAli database includes approximately 35000 alignments of pairs of protein structures from SCOP (Lo Conte et al., Nucleic Acids Res., 28, 257-259, 2000) and CE (Shindyalov and Bourne, Protein Eng., 11, 739-747, 1998). PLCgamma1 and delta1 were expressed neither in the OHCs nor in the IHCs. Hysterectomy with extended surgical staging and radiotherapy versus hysterectomy alone and radiotherapy in stage I endometrial cancer: a comparison of complication rates.

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Association between the IL-1 family gene cluster and spondyloarthritis. The various strategies to overcome the limited number of available grafts appear effective but not universally applied and accepted. In the absence of edema, measurements with the reflectance meter appeared to be more sensitive than visual scoring. Some cases of conjunctivitis and of keratitis due to hydrogen sulfide in a beet sugar factory Little is known about the sensitivity, specificity, and predictive values of transabdominal ultrasonographic (US) findings in a teaching hospital setting.

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The hexapeptide KP-102 (D-ala-D-beta-Nal-ala-trp-D-phe-lys-NH(2)) stimulates growth hormone release in a cichlid fish (Ooreochromis mossambicus). Literature review shows the congenital origin of the disorder and how it is to be treated. The highest frequency of funisitis was observed in cervical insufficiency among cases with spontaneous preterm birth.

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Serum taken at 2 to 4 weeks following transplantation (when thrombotic events might be anticipated) was analysed further in 132 patients undergoing liver transplantation. Rapid regression through bromocriptine therapy of a suprasellar extending prolactinoma during pregnancy. The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax.

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Transcriptional regulation of major histocompatibility complex class I by flavivirus West Nile is dependent on NF-kappaB activation. The lack of genetic influences on conduct problems-ASD overlap further supports the genetic independence of these 2 phenotypes. The results revealed that a higher molar ratio of Tween 80 yielded smaller CSLNs, higher charge of CSLNs and larger electrical attraction energy between CSLNs and HBMECs. Rapid response of a marine mammal species to holocene climate and habitat change.

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Complex synaptic responses of entorhinal cortical cells in the rat to subicular stimulation in vitro: demonstration of an NMDA receptor-mediated component. The vaccine efficacy of native paramyosin (Sj-97) against Chinese Schistosoma japonicum. Endothelin-1 is involved in the growth promotion of vascular smooth muscle cells by hyaluronic acid. TJRB is a new diagnostic method, which, looking at its indications, facilitates the diagnosis of glomerulopathies in patients who could not be considered for percutaneous renal biopsy, particularly due to clotting disorders.

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We hypothesize that, as genotypic canalization enables differentiation despite random mating and increases the effectiveness of assortative mating, sympatric speciation is more likely than is commonly suggested. Analysis of the late results of the surgical treatment and longterm follow-up of non-operated patients with chronic benign diseases of the stomach evidences gastric cancer high-risk in patients with anacid gastritis, polyposis and ulcerous disease. The sacral artery, overlying the anterior aspect of the L5/S1 disc space, was retracted, allowing the exposure of the disc space. Dot-like labelling with anti-tubulin antibodies was often observed in the perinuclear space, but not microtubules were recognized in the nucleus. Haemodynamic and EKG changes in patients undergoing minimally invasive direct coronary artery bypass.

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A randomized comparison of the 3 Papanicolaou smear collection methods. However, rat airway mucin did not show any cross-species immunoreactivity against human and hamster airway mucin. Inclusion criteria concerning treated eyes in the ranibizumab group complied with the MARINA and ANCHOR studies. Thus, IL-10 does not act as a direct antagonist of uNK cell function and activation. Lapachol, a naphthaquinone isolated from the roots of Tectona grandis given at a dose of 5 mg kg-1 p.o.

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Graft-versus-leukemia in rat MHC-mismatched bone marrow transplantation is merely an allogeneic effect. The present method can be used in toxicological analysis for determination of MT concentration in physiological fluids in subjects exposed to heavy metals. The amino acid sequence of toxin RpIII from the sea anemone, Radianthus paumotensis. The cause is sleep apnea, which often is worsened in the postoperative state due to narcotic analgesics.

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Surgical correction is generally indicated as the primary form of management in children with severe early onset scoliosis. The major steps of our technique include early inter-aortocaval control of the right renal artery, circumferential mobilization of the IVC, contralateral renal vein control, cavotomy, thrombectomy, and reconstruction of the IVC. A FACTOR ANALYTICAL STUDY OF INTELLECTUAL AND NON-INTELLECTUAL CHARACTERISTICS. Caylobolide A, a unique 36-membered macrolactone from a Bahamian Lyngbya majuscula.

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Precise localisation of the genes for resistance to chloramphenicol, kanamycin, fusidic acid and tetracycline was possible due to the presence of identified restriction endonuclease cleavage sites within these determinants. It is found for all measured colloid volume fractions that the diffusivities decrease linearly with increasing strength of the polymer-mediated depletion attraction at a fixed polymer molecular weight. Eleven case-control studies including 2168 cases and 4058 controls were identified from electronic databases (Pubmed, Elsevier Science Direct, Chinese National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), and the Chinese database, Wanfang).

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Nitrergic cerebral vasodilatation provoked by the periaqueductal grey. Fifteen children, median age 3.9 (0.5-13.3) years had a percutaneous gastrostomy (PEG) or Nissen fundoplication and gastrostomy (N and G) or open gastrostomy (OG) before starting PD (group1). Eight metal foreign bodies (3 slices, 3 nails, 1 fish hook, 1 needlepoint) were successfully removed under 3D CT guidance in all patients. Thus, concentrations of Ba achievable in vivo at sites of active inflammation were found to act on human B lymphocytes by inhibiting their proliferation.

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Combined induction of penicillinase in Bacillus cereus by means of various inducers. Health and health care for the Palestinians of the West Bank and Gaza Strip. The paper reviews the information available concerning the mutagenic, teratogenic and carcinogenic effects of antimony. To further probe the relationship between the frizzled-like and inturned-like genes we determined the consequences of altering the activity of frizzled-like genes in wings that carried weak alleles of inturned or fuzzy. In this study, we undertook a yeast two hybrid screen to identify Foxk1 interacting proteins.

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Noninvasive brain stimulation (NIBS) techniques including transcranial electrical and magnetic stimulations (tES and TMS) have provided promising opportunities for the addiction medicine in two main domains: (1) providing new insights into neurochemical and neural circuit changes in the human brain cortex and (2) understanding the role of different brain regions by using NIBS and modulating cognitive functions, such as drug craving, risky decision making, inhibitory control and executive functions to obtain specific treatment outcomes. Aterial hypertension and cardiovascular risk factors associated with diabetes. It remains unclear whether there is a single but different underlying mechanism responsible for these multiple abnormalities in each of the three clinical situations.

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The results demonstrate that vasopressin increases plasma levels of corticotropin, cortisol and glucose in cattle, as it does in sheep, but the intensities of the corticotropin and glucose responses to vasopressin differ between cattle and sheep. I begin with a brief historical sketch of the major developments in this field and then focus on three of the most significant evolutionary transitions in the reproductive biology of flowering plants: the pathway from outcrossing to predominant self-fertilization, the origin of separate sexes (females and males) from hermaphroditism and the shift from animal pollination to wind pollination. Course of cases of pulmonary tubercurosis with bacilli resistant to streptmycin, para-aminosalicylic acid and isoniazid and with multiple drug-resistance.

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The primary commentary introduced the Back Squat Assessment (BSA): a criterion based assessment of the back squat that delineates 30 potentially observable functional deficits. Microdissection of single chicken microchromosomes (MICs) followed by degenerate oligonucleotide-primed (DOP) PCR allows the rapid generation buspirona 5 mg emagrece of MIC-specific DNA libraries. Differences in degree of trapping of low-affinity uncompetitive N-methyl-D-aspartic acid receptor antagonists with similar kinetics of block.

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Osteomalacia in a 80-year old woman with malabsorption due to the stagnant loop syndrome is reported. Inhibitory effect of somatostatin on cholera toxin-induced diarrhea and glycoenzyme secretion in rat intestine. As far as penetrating chest wounds, and bites are concerned, the evidence is perhaps as yet inconclusive, baclopar tablets at best but antibiotics are probably not indicated in these situations.

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Six uncharacterised CSFV isolates from 1996 to 2007 were assessed in animal experiments for their clinical virulence in order to broaden the knowledge about circulating CSFV and thereby assist disease eradication. Inhomogeneous enhancement was seen in three lesions on postcontrast T1-weighted images obtained with fat-saturation techniques. Sulphasalazine in the long term management of rheumatoid arthritis. The advantages of organ culture and epithelial joicaster vs restream solutions cell culture were combined in this new culture system.

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