Genoxal is a cytotoxic (cytostatic), cell-cycle-nonspecific, antiproliferative agent that is used in such diverse medical problems as neoplasia, tissue transplantation, and inflammatory diseases. It is an inert prodrug for a potent nitrogen mustard alkylating agent. After the metabolic activation of Genoxal to the potent mustard by liver enzymes, a nonenzymatic generation of chemically reactive molecules occurs. These reactive molecules can form covalent bonds with biologically ubiquitous groups, such as amino, phosphate, hydroxyl, carboxyl, sulfhydryl and imidazole, and as a result, depending on dose, Genoxal is capable of either interfering with the reproduction of cells or killing cells. This is especially true in the case of rapidly dividing cells.
Other names for this medication:
Cyclophosphamide,
Cytoxan,
Ciclofosfamida,
Cryofaxol,
Cycloblastin,
Cycloxan,
Cycram,
Endoxan,
Endoxana,
Genoxal,
Neosar,
Procytox,
Sendoxan,
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