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Genoxal (Cyclophosphamide)

Genoxal is a cytotoxic (cytostatic), cell-cycle-nonspecific, antiproliferative agent that is used in such diverse medical problems as neoplasia, tissue transplantation, and inflammatory diseases. It is an inert prodrug for a potent nitrogen mustard alkylating agent. After the metabolic activation of Genoxal to the potent mustard by liver enzymes, a nonenzymatic generation of chemically reactive molecules occurs. These reactive molecules can form covalent bonds with biologically ubiquitous groups, such as amino, phosphate, hydroxyl, carboxyl, sulfhydryl and imidazole, and as a result, depending on dose, Genoxal is capable of either interfering with the reproduction of cells or killing cells. This is especially true in the case of rapidly dividing cells.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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Effect of the free radical-generating herbicide paraquat on the expression of the superoxide dismutase (Sod) genes in maize. A 79-year-old man in a cancer-prone family developed disseminated seborrheic keratoses over his trunk and extremities over a few decades without rapid increase. These two domains are differentially regulated in HeLa cells and primary cultures of dorsal root ganglion neurons when they are placed in the context of a reporter gene driven by the c-fos minimum promoter. Cyp17 promoter variant associated with prostate cancer aggressiveness in African Americans.

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It is concluded that SS-14 and SS-28 delivered by IP infusion, inhibit basal and stimulated gastric acid equally in the rat without suppressing gastrin. A simple modification of nursing care had an impact on the sleeping and waking states of preterm infants.

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The newly licensed tetravalent rhesus-human reassortant rotavirus vaccine has been withdrawn following reports of intussusception among vaccinated infants. Patients surviving high-voltage electrical injury may have early and delayed sequelae. Recent findings on sPLA2s support the idea that the enzymes contribute to human atherogenesis not only as initiating agents but also in maintaining plaque inflammation. Aortic incompetence in pauciarticular juvenile chronic arthritis.

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Lack of the requisite cleavage of the His271-Thr272 bond in prothrombin Padua I could prevent release of fragment 2 and block the conversion of the intermediate meizothrombin des fragment 1 to alpha-thrombin, providing an explanation of reduced potential for clotting activity and for the observed mild bleeding tendency. Surprisingly, arginine also lessened lactic acid-mediated cell wall/membrane disruption. The epithelium of the explants retained a near normal morphology for 2 to 4 weeks.

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from Atlantic salmon, Salmo salar, and Sphaerospora truttae: a revised species description for S. The theoretical results also indicate that excluded-volume forces resulting from the different sizes of the salt ions cannot alone account for the salting-in and salting-out phenomena seen in aqueous nonionic micellar solutions. Vitamin C Facilitates Demethylation of the Foxp3 Enhancer in a Tet-Dependent Manner. An instrument was developed to assess the perceived need for communication training for specialists in poison information (SPIs) with input from focus groups and a panel of experts.

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More severe LUTS are associated with higher healthcare consumption and cost. Vasculitis and steroid therapy--evaluation of management based on the modified lesion and pathological observation This either indicates lower sensitivity of inter-connectivity measures to detect subtle DMN changes or indicate that ICA and time course analyses determine different properties of DMN co-activation. Hearts isolated from these animals showed decreased coronary flow and left ventricular developed pressure (LVDP), and total mechanical performance.

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Organisation of xanthophyll pigments lutein and zeaxanthin in lipid membranes formed with dipalmitoylphosphatidylcholine. Initial enthusiasm for this therapy has waned with the realization that response rates are low and relapses are common. Adolescent drinking, social identity, and parenting for safety: Perspectives from Australian adolescents and parents. The prompt detection and effective management of infectious disease in wildlife rely greatly on field diagnosis.

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Our study suggests the PICU outcome for these patients has improved. Systemic L-NG-nitroarginine methyl ester or L-NAME (LN), a nitric oxide synthase inhibitor, has been reported to attenuate systemic opioid tolerance and withdrawal. However, intestinal OAT was more labile than hepatic OAT to tryptic digestion. This is the 18th case of retrovesical leiomyoma reported in the literature in Japan.

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Assessing the contribution of a standardized method in defining the tumor bed using surgical clips in breast cancer Chronic actinic dermatitis (photosensitivity dermatitis/actinic reticuloid syndrome): beneficial effect from hydroxyurea. Local anesthetics in the aqueous humor in local anesthesia of the eye Maternal satisfaction with childbirth is influenced by mode of delivery.

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Mechanisms of apoptosis in tumor cells is an important field of tumor therapy and cancer molecular biology. Patients with mutations in C9orf72 can have amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), or ALS-FTD. Plasma pharmacokinetics of Adriamycin (doxorubicin) has been studied after intraneoplastic administration during electrochemical treatment to patients with lung cancer that is noncurable with radiotherapy, surgery, or chemotherapy. Salus populi - the endeavours of Edward Dillon Mapother (1835-1908). Inositol 1,2,3-trisphosphate and inositol 1,2- and/or 2,3-bisphosphate are normal constituents of mammalian cells.

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The detection of thyroxine and related substances on paper chromatograms by the ceric sulphate-arsenious acid reaction. Location and domain structure of Escherichia coli ribosomal protein L7/L12: site specific cysteine crosslinking and attachment of fluorescent probes.

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One such issue is that of clustering of observations at the various stages of sampling. The experiments were performed on female Wistar rats that received aluminum chloride every day intraperitoneally, 4 mg Al/kg for 3 weeks. Effects of biotin deficiency on serum fatty acid composition: evidence for abnormalities in humans. Phrenic nerve trauma in the absence of direct injury is unusual and may present diagnostic difficulty. SFD and chronic pain showed distinguishable attributional patterns.

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Within rat, relatively high activity was found in P2 fractions of whole hypothalamus, cerebellum, and hippocampus. This report deals with the identification of novel elements belonging to a family of endogenous retroviruses, designated ALVE, that reside in the genome of the chicken and that are closely related to exogenous avian leukosis viruses. Eight C57BL/6J mice were immunized by intravenous injection of 1 x 10(6) DC-HBsAg. Gonocytes were quantified according to degree of relocation into nonrelocated, relocating and relocated. Other independent risk factors for retinal detachment include axial length, myopia, posterior capsular rupture during surgery, history of retinal detachment or lattice degeneration, and ocular trauma after cataract surgery.

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However, an original isolate of this strain which had not undergone sub-culture gave a positive result by both RTPCR and bioassay. One-hour incubation with the cytostatic modulated apoptosis in cell culture. There are too few rewards for researchers to pursue research with potential for widespread application, and to systematically develop promising interventions to a stage of field dissemination.

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The hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis in all metazoan species. Amygdala-hippocampus relationships in temporal lobe seizures: a phase-coherence study.

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B cells are known to play an important role in the pathogenesis of several autoimmune diseases. Endoscopic examination with biopsy revealed about a 1-cm early gastric cancer of signet-ring cell type at the lesser curvature side of the antrum. We present the case of a 62-yr-old patient who developed severe swallowing problems 5 yr after radiotherapy for a pharyngeal carcinoma. Prognostic factors in autologous stem cell transplantation for multiple myeloma: an EBMT Registry Study.

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The pathophysiology of neurologic and neuropsychologic impairments remains unknown. Prior to ultralow friction behavior, H-DLC exhibits a run-in period. Fertility rates after ectopic pregnancy (EP) were compared between the Auvergne region (central France) and the Lille region (northern France) in order to determine whether fertility factors are similar.

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Although intense medical therapy including antifungal agents, diuretics, catecholamines and digoxin was initiated, the patient died from multiple embolisms 9 days later. In response to FGF-2 posterior limb bud cells move in both a proximal and a distal direction, causing the initially labeled cell population to bifurcate into two distinct domains. Further research needs to be undertaken to include comparison between self-reported studies and observational studies, as it has been shown that healthcare workers may rationalise their behaviour and that self-reporting can be unreliable. Targeting isocitrate lyase for the treatment of latent tuberculosis.

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Using large-volume presses, it is now possible to measure X-ray absorption spectra under a wide range of pressure-temperature conditions. One challenge academic health centers face is to advance female faculty to leadership positions and retain them there in numbers equal to men, especially given the equal representation of women and men among graduates of medicine and biological sciences over the last 10 years. Pediatric kidney transplantation and living donors--invaluable by virtue of necessity

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Successful treatment of recurrent hypoglycemia by pioglitazone in a patient with myotonic dystrophy Activation of HIV-1 gene expression is regulated by a nascent RNA structure, termed TAR RNA, in concert with HIV-1 Tat protein and these positive and negative elongation factors.

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On microscopic evaluation the lesions were well circumscribed, and the tumor cells were spindle-shaped with a fascicular and sometimes whorled pattern. Immunosuppression may lead to progression of hepatitis C virus-associated liver disease in hemophiliacs coinfected with HIV.

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Cigarette smoking was related to several outcomes at the 0.05 level: aspartate aminotransferase, alanine aminotransferase, glutamate dehydrogenase (GLDH), erythrocyte sedimentation rate, and white blood cell count. A strength of PF cell lines over other cell lines is that the parental PF cells have serotonergic properties and a neuronal potential that is consistent with their neural crest origin. Uptake, penetration, and binding of monoclonal antibodies with increasing affinity in human osteosarcoma multicell spheroids. The variation in selectivity observed for the catalysts containing seven-membered, flexible chelate rings is apparently due to changes in their conformation in the less polar micellar medium, and this effect is also seen in organic solvents.

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Biopsies from the sural nerve and normal-looking skin both proved the existence of amyloid. Endothelin-1 stimulates glucose transport in murine 3T3 adipocyte lineage, but not in human subcutaneous fat cells.

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Resonant Raman scattering based approaches for the quantitative assessment of nanometric ZnMgO layers in high efficiency chalcogenide solar cells. The reversal of the antagonism could be the result of the block of purinergic P1-receptors by theophylline.

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Prostacyclin-induced vasodilation in rabbit heart is mediated by ATP-sensitive potassium channels. Initial studies using deuterated desogestrel confirmed that desogestrel is metabolised by human liver microsomes via 3alpha-hydroxy and 3beta-hydroxydesogestrel to 3-ketodesogestrel. Effects of chondroitinase ABC on degenerative intervertebral discs. MOBP levels are regulated by Fyn kinase and affect the morphological differentiation of oligodendrocytes.

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The decision whether to create a loop ostomy or a terminal stoma is reached with respect to the underlying indications and the anatomical and pathophysiological situation. This is the diagnostic experiences as well as the surgical mode of treatment used in a 31 years old women suffering diversion of the inferior vena cava into the left atrium associated with atrial septal defect. Independently of this, it was found that a part of alcoholic patients treated with disulfiram (tetraethylthiuram disulphide) showed a cross-reaction to TMTD. Developmental process of musculoskeletal integration in ostracod antenna.

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PlantsP also provides a curated view of each protein that includes a comprehensive annotation of functionally related sequence motifs, sequence family definitions, alignments and phylogenetic trees, and descriptive information drawn directly from the literature. Alternating floxuridine and 5-fluorouracil hepatic arterial chemotherapy for colorectal liver metastases minimizes biliary toxicity. A repeated crossover study, carried out with the same information-gathering procedures in two periods 10 years apart. Creutzfeldt-Jakob disease (CJD) or spongiform encephalopathy in humans, is a rare, rapidly progressive and fatal disorder of the central nervous system. The aim of this study was to develop decision support formulas and nomograms for the prediction of bladder outlet obstruction (BOO) and for BOO-related surgical decision-making, and to validate them in patients with LUTS/BPH.

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Thermally induced degradation of sulfur-containing aliphatic glucosinolates in broccoli sprouts (Brassica oleracea var. Ascitic fluid adenosine deaminase insensitivity in detecting tuberculous peritonitis in the United States. Biological effects were studied by thymidine incorporation and glucose accumulation. In dapsone tab 100 mg addition, a strong expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) was observed in the acute rejection group. The use of highly sensitive and selective methods (autoradiography, light and electron microscopy, radioimmunoassay) allowed identification of peptide hormones in both the specialized endocrine cells (apudocytes) of some internal organs and various structural elements of the central and peripheral nervous system.

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To identify novel regulators responsible for this growth sulbacin unichem pharmaceuticals phase dependency, a P. This substance, called ruminococcin A, was purified to homogeneity by reverse-phase chromatography. Flexible Bronchoscopy Is Safe and Effective in Adult Subjects Supported With Extracorporeal Membrane Oxygenation. Heterogeneity of ventilation-perfusion ratios was larger in COPD.

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Furthermore, we provide evidence that the accelerated degradation of TRAF6 requires both its ubiquitination, which is initiated by RANKL, and IFN-gamma-induced activation of the ubiquitin-proteasome system. Expression levels by retroviral vectors based upon the N2 and the MFG backbones. Effect of the addition of the 3rd agent on the combined therapy with ethionamide and kanamycin in tuberculosis in the mice A threshold level of TLR9 mRNA predicts cellular responsiveness quantum 500 mg levofloxacino nombres to CpG-ODN in haematological and non-haematological tumour cell lines.

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