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Granisetron is the second candidate drug of a class of selective serotonin antagonists that has been shown to be an effective antiemetic agent for patients receiving radiation or chemotherapy treatment. This approach is also applicable to data sets derived from some other types of biological systems, such as transcription factor-mediated regulation of gene expression during the control of developmental fate, or host defense responses following pathogen attack, and is equally applicable to plant and non-plant systems.

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The material comprised 22 randomly selected electricians attending health checkups, and reporting neck pain during the past week. Factor analysis demonstrates that the cepstrum peak magnitude indeed is sensitive to aperiodicity of vocal fold vibration as well as to insufficient vocal fold closure and excessive turbulent noise escape, and that it may be considered as a relevant acoustic correlate for the G (Grade) parameter of the GRBAS scale. The impact of these strategies on the number of infected individuals and the accumulated cost is assessed and compared with the constant control case. To evaluate the ability of bacterial starters to produce methyl ketones it was necessary to develop a rapid method. Characterization and cloning of two Rhizobium leguminosarum genes coding for glutamine synthetase activities.

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Preparation, characterization, and in vivo biodistribution properties of synthetically cross-linked multivalent antitumor antibody fragments. Developmental toxicity: web resources for evaluating risk in humans. In purified peripheral human T cell blasts or the 2B4 murine T cell hybridoma, apoptotic cell death induced by immobilized anti-CD3 was blocked by inhibitors of NO synthase (NOS) in a stereospecific and concentration-dependent manner. Consequently research has become focused on efforts to identify molecules that are able to control CSMC proliferation. Lying Down Instability Undetected on Standing Dynamic Radiographs.

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Pigmented squamous cell carcinoma of the skin: report of two cases and review of the literature. Tricyclic antidepressants and monoamine oxidase inhibitors also have been used successfully, and high-potency benzo-diazepines are an option when rapid onset of drug activity is desired.

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Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease. Practical issues, like time demands, also seemed to be important.

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Information on case history, physical examination (diagnosis of heart failure, NYHA class, heart failure symptoms), laboratory tests (resting ECG, chest X-ray, echocardiogram) and data concerning pharmacology management during the 2 weeks prior to the index visit was obtained. The inhibition by their combination was additive if bacterial cells were treated with HOSCN/OSCN- before exposed to immune whey product. Finally, we have already begun to test a hypothesis of parallel processing deficiency in OCD by using a dual-task version of the SRT that makes simultaneous demands on implicit and explicit information processing systems (128). Because of its unique characteristics, the cornea has been widely used for blood and lymphatic vessel research. The results indicate that these substances, commonly used in contraceptive pills, do not change vasotonus interfering with calcium homeostasis.

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Convergent validity was demonstrated by a significant positive correlation between the negative emotions and situations scores of the EMAQ and the emotional eating subscale score of the DEBQ (DEBQ-E). Copy number variation (CNV) is an important source of genetic variability associated with phenotypic variation and disease susceptibility.

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In addition, the size of the residue substituted at position 121 correlated directly to the degree of blue-shift in the lambdamax value of the pigment. The routine testing of biological medicines, excluding vaccines and pyrogen tests, is examined. Asthma is an inflammatory respiratory condition with significantly associated morbidity and mortality that is increasing in prevalence.

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Gastric ulcer and duodenal ulcer, but not gastric cancer, were significantly associated with chronic diseases of the joints, lungs, pancreas, and liver. However, after subjects wore a plus lens over their nonsighting eye for one day, interocular suppression of blur became enhanced when the nonsighting eye was blurred, and it became reduced when the sighting eye was blurred. Fallopian tubes were harvested at the time of abdominal hysterectomy and processed by standard tissue culture techniques. To study the effect of X-ray on gene transfer and the antitumoral effect of X-ray combined with suicide gene therapy on colorectal carcinoma cells. Growth factors other than PDGF-BB and IGF-I contribute significantly to this process.

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The model is directed towards the analysis of static working situations where the load is low or moderate. It is also effective for immunological staining of samples after ISH with a riboprobe. Therefore, understanding the mechanisms underlying the metastatic process is necessary for future prevention and treatment. In vitro kinase assay for FGF receptors revealed that FGF receptor 1 and 2 were autophosphorylated after FGF stimulation.

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Re-emergence of the progenitors of a multidrug-resistant outbreak strain of Mycobacterium tuberculosis among the post-outbreak case patients. Long-term treatment with oestradiol implants does not convey cognitive benefits and may lead to impaired function. Definition of a consensus DNA-binding site for the Escherichia coli pleiotropic regulatory protein, FruR. Third cranial nerve palsy or pseudo 3rd nerve palsy of myasthenia gravis?

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Prevalences of hay fever, eczema, specific sensitization to pollen and house dust mite increased, while the prevalence of contact to cat and dog decreased with parental educational level. All patients with a Gleason score more than 4, PSA more than 10 ng./ml.

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Obstacles to the optimal management of HIV infection/AIDS in Africa. However, in contrast to our previous findings, our gel mobility shift analyses demonstrate that this CRE/ATF element is bound by similar proteins in nuclear extracts prepared from undifferentiated and differentiated mouse EC cells as well as from undifferentiated human EC cells.(ABSTRACT TRUNCATED AT 250 WORDS) Finally the sparse knowledge on the haemostatic mechanisms of current endoscopic therapies is presented.

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The decimal reduction times of Streptococcus faecium, Listeria monocytogenes, Salmonella enteritidis, and Aeromonas hydrophila corresponding to heat treatment at 62 degrees C were 7.1, 0.34, 0.024, and 0.0096 min, and those corresponding to manosonication treatment (40 degrees C, 200 kPa, 117 microm) were 4.0, 1.5, 0.86, and 0.90 min, respectively. They were less successful in assessing minor medical conditions and respiratory emergencies other than wheezing. Therefore, elastic matching is the gold standard for the registration of dynamic MR mammographic images of the female breast. Patients received either a loading dose of 0.5 mg/kg diazepam followed by an infusion of 1 mg/kg over 24 h or an equivalent volume of placebo. Based on studies of animal models of human amnesia and histopathological findings in the irradiated brain, the neurocognitive sequela of cranial irradiation can be seen to be mediated through vascular injury, resulting in ischemia and hypoxia in the hippocampal region.

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Fluorescent microspheres were administered before and during CPB at four randomized flows: 1.9, 1.6, 1.3, and 1.0 L x min(-1) x m(-2). The recent emphasis on permanency planning in child welfare has strengthened the resolve of policy makers and service providers to serve the families of dependent children better. The effect of heparin on fibronectin and thrombospondin synthesis by human smooth muscle cells.

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The gathering and presentation of this information may subject the journalist to a variety of physical and psychological hazards. The potential prognostic value of this finding needs further investigation.

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Regulated delivery of therapeutic proteins after in vivo somatic cell gene transfer. After vitreoretinal surgery, the retina RE was attached and recurrence of hydatid disease was not seen in vitreous cavity or subretinal space during the follow-up period.

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The success of academic-community collaborative programs depends not only on the good will and vision of the participants but also on the medical administration, academic leadership, policy makers, and politicians who define the principles and rules by which cooperation within the health care industry occurs. The illness was caused by a dental infection due to Streptococcus constellatus proved by isolation from blood culture, the origin was a decayed tooth.

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The effect of specular reflection, background color and specimen thickness on the color of four commercial denture resins was studied by reflection spectrophotometry. The purpose of this study was to review the outcome following concomitant chemoradiation therapy in previously irradiated patients with locally or regionally recurrent or persistent head and neck cancer considered unresectable for cure. The importance of the Cairo Genizah for the history of medicine.

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Furthermore, the use of a small sampling area (high power field of view) is likely to result in an unacceptably large uncertainty (variability) in the GCD estimates. Determination of vitamin B 12 in the blood of healthy and in that of persons suffering from allergic dermatitis

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Undertaking better sanitary and preventive service for the population The livers were screened for preneoplastic foci 12 weeks after starting the experiments. To determine the imaging characteristics of lumbar facet joint synovial cysts after percutaneous treatment with steroid injections and distention of the cyst and to correlate these findings with the clinical outcome.

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We used a generalised additive model with a quasi-Poisson distribution to examine the association between mortality and Tmax/Tmin/Tmean values higher than the threshold values, after adjustment for covariates. Our studies of a skeletal malformation syndrome, nail-patella syndrome, have shown how the LIM homeodomain transcription factor, Lmx1b, contributes to transcriptional regulation of glomerular basement membrane collagen expression by podocytes.

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Mucosal IgA is polymeric and bound to secretory component, whereas serum IgG is monomeric. Purified DMV-N protein was used as antigen in an indirect ELISA (iELISA) and shown to react with rabbit and human antisera to measles virus (MV) and dog sera with antibodies to canine distemper virus (CDV).

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It is important to understand how male slings work and by doing so we are more reliably able to choose the appropriate sling, predict outcomes, and as a result counsel patients. To evaluate the diagnostic performance of MR arthrography in the detection of articular cartilage and labral lesions of the glenohumeral joint using a transverse 3D water-excitation true fast imaging with steady-state precession (FISP) sequence. Reversed immunosorbents: a simple method for specific antibody immobilization.

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Modulated imaging is a new modality capable of wide-field, spatially resolved measurement of in vivo optical properties. Study in fluid media and at low temperature of reaction of bioluminescence emission of Photobacterium Leiognathi The DIS system meets general requirements on individual monitoring of hospital personnel using ionising radiation.

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Description of a case associated with familial mental retardation CK18 was expressed to a greater extent on the epithelium of thymic carcinomas than on that of thymomas. Furthermore, this endogenous antinociceptive system may be enhanced in diabetic mice.

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Senior-led freshman groups: a strategy for professional development. All were patch tested with the European standard patch test series and the standard supplemental series, as well as special series for dyes and hairdressers. Transition to managed care will bring changes for oncologists, need for guidelines, says ACCC panel. During cytokinesis in animal cells, an equatorial actomyosin-based contractile ring divides the cell into two daughter cells. Molecular mechanics calculations on HIV-1 protease with peptide substrates correlate with experimental data.

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Very young children with medulloblastoma have a worse prognosis than older children. We briefly review the reported cases of familial testicular cancer and discuss the association of the maldescent of the testes and familial testicular cancer cases. GP services were used most often in areas where availability of specialized outpatient clinic services was low. For this, phylogenetic and coalescent analyzes were performed on NUMTs and authentic mtDNA sequences generated from eight horseshoe bat species. Epidemiological and experimental studies have overwhelmingly confirmed human papillomaviruses as important causal agents in anogenital carcinogenesis.

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In the dialysis group, cystic involvement of the wrist was more common and the size and number of the cysts were larger. Pericarditis, myocarditis, inflammation of the atrioventricular conduction system, and endocarditis with valvulitis were also present.

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The varicograms of 128 legs were reviewed by a panel of two vascular surgeons and a radiologist with a specialist vascular interest. This article reviews recent developments in targeted radionuclide therapy (TRT) approaches directed to malignant liver lesions, bone metastases, neuroendocrine tumors, and castrate-resistant metastatic prostate cancer and discusses challenges and opportunities in this field. Such instances are low volume/high risk, creating difficulty for staff to gain and maintain proficiency with the equipment and processes related to the MTP in a secure environment. Plasma neuroleptic levels in the elderly patients on propericiazine therapy--possible role of morbidity.

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Neuroleptic plasma concentrations and clinical response: in search of a therapeutic window. Robotic prostatectomy: The new standard of care or a marketing success?

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Although the ultimate target of infection is the central nervous system (CNS), there is evidence that the enteric nervous system (ENS) and the peripheral nervous system (PNS) are involved in the pathogenesis of orally communicated transmissible spongiform encephalopathies. Independent t chromosomes found in wild mice from US populations also had unique patterns, even when they were classified within the same lethal complementation group.

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N-tropomodulin: a novel isoform of tropomodulin identified as the major binding protein to brain tropomyosin. The recombinant mutant PP2A alpha proteins Y265F, C266G, Y267G and C269Y were resistant to okadaic acid, with IC50s of 10, 24, 20 and 10 nM, respectively, as opposed to the recombinant wild PP2A alpha protein which had an IC50 of 0.24 nM. The study uses longitudinal data in a cohort of 4852 children born between 1983 and 1989.

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Contact lens wear at altitude: subcontact lens bubble formation. T cells depend on costimulation by accessory cells for an immune response. We have suggested that the formation of steep early negative shifts from the baseline in time group averages was due to synchronization of a mental process which, under classical averaging procedure, was dispersed uniformly throughout the pre-movement period. Breathing during CPT was either spontaneous or paced at 0.23 Hz or 0.1 Hz. This influence has particular importance in the mesocorticolimbic dopamine system, which serves during the reinforcement of rewarding behaviors.

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Evidence is presented here that cytochrome P-450 inhibition may protect against hepatic damage induced by acetaminophen and other drugs metabolized via this system. AYA cancer patients appear to experience a unique symptom profile with high symptom prevalence and complexity. Devoting resources to the effective treatment of essential hypertension itself should be a priority, because such treatment has been shown to reduce morbidity and mortality associated with hypertension and related cardiovascular diseases. These results indicate that the hinge region of Ada is important for ada but not alkA transcription and further support the notion that the mechanism(s) by which Ada activates ada transcription differs from that by which it activates transcription at alkA.

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Annotation of a serum N-glycan library for rapid identification of structures. We conducted a retrospective study to analyse the incidence and spectrum of bacterial infections in HIV-infected children compared to HIV-exposed but not infected controls related to their immunological status. Risperidone-induced hyperamylasemia, hyperlipasemia, and neuroleptic malignant syndrome: a case report. It is closely associated with, but evolutionarily distinct from, the Src family members.

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Middle ear effusion containing floating tumor cells was observed in 4 temporal bones of 3 patients. Increased ponto-geniculo-occipital (PGO) wave frequency following central administration of neostigmine. Double-walled (DW) polymer microspheres with a core of poly(1,3-bis-(p-carboxyphenoxy propane)-co-(sebacic anhydride)20:80 (P(CPP:SA)20:80) and an external coat of poly(L-lactic acid) (PLLA) were degraded for up to 6 months in vitro. Acute ethanol administration induces oxidative changes in rat pancreatic tissue. The role of lysine-132 and arginine-136 in the receptor-binding domain of the K99 fibrillar subunit.

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Magnetotherapy in the combined treatment of the suppurative complications of open injuries of soft tissues and bone Biological membrane outer surfaces are negatively charged and interact with positively charged calcium ion during calcium uptake.

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Trends in these inequalities were examined in the light of the decline in CHD mortality in Great Britain. The liver damage arising from RHF was assessed by changes in liver biochemistry and histopathology. Local application of statins has shown potential in preventing and regenerating bone loss associated with experimental periodontitis. A novel approach to data collection in a case-control study of cancer and occupational exposures.

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Against a varied distribution of primary medical care opportunities within the District, substantial differences are demonstrated in their use by lower- and middle-status residents of a lower-class community. Preparation of iodine-125-labeled insulin for radioimmunoassay: comparison of lactoperoxidase and chloramine-T iodination. The repertoires were then screened for the presence of antibodies directed to CRC by selection on the cell line CaCo2. The combined predictions of the ANN model were slightly more accurate than either the new or the old Denver models. This increase in survival is associated with HIV/AIDS becoming a chronic multiorgan system disease that requires a multidiscipline comprehensive care approach.

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Second, control of the calcitonin/calcitonin gene-related peptide (CT/CGRP) gene will be discussed, with particular emphasis on the application of serotonergic drugs in treating migraine headaches. Some implications for psychoanalysis of modern concepts of the organization of the brain.