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LEAPS Vaccine Incorporating HER-2/neu Epitope Elicits Protection That Prevents and Limits Tumor Growth and Spread of Breast Cancer in a Mouse Model. Sprague-Dawley rats were used as the experimental animals and the livers were the targets. To explore the preventive effect of BCG vaccine on asthma attack in rats and its relation with gamma delta T cells.

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The addition of NaCl, KCl, or guanidine hydrochloride below 1 M stabilized the dimer in a similar manner. Discomfort manifested by colic-like clinical signs in 2 young mares was presumed to be attributable to ovarian pain associated with follicular enlargement and ovulation. Both cell growth (cell mass increase) and progression through the cell division cycle are required for sustained cell proliferation. Intensity and precision of circadian wheel running in three outbred rat strains.

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Neuropathy, hereditary motor and sensory type I, II, hereditary with pressure palsies Further studies, by evaluating the effect of a chronic treatment, will be required to define which is the action of melatonin on PRL release in PRL secretion disorders, and to evaluate its possible therapeutic role. Deinococcus radiodurans is able to resist and survive extreme DNA damage induced by ionizing radiation and many other DNA-damaging agents. Seventeen canine patients receiving Nexterone (five of which were treated during cardiopulmonary arrest).

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Decrease of serum zinc levels after administration of semicarbazide. The expression of apoptosis-related factors, such as BAD, APAF1 and BCL-2 was examined by Western blot analysis. Benign proctological conditions are very common in Western civilization.

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Thus, this gene (cimA) encodes an (R)-citramalate synthase (CimA). Using the post-translational assay system, we investigated the effect of the depletion of ER lumenal content proteins on the folding and assembly of the MHC class II chains. No significant homologies were noted among the three deduced gene product amino acid sequences, confirming that T beta molecules of ATL cells contained no specific structures in common. Ring filter to locate external boundaries in SPECT using scattered radiation.

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We study the exact ground state of the two-dimensional random-field Ising model as a function of both the external applied field B and the standard deviation sigma of the Gaussian random-field distribution. Here, we report that interleukin 1 (IL-1) enhances the production of the precursor of MMP-9 in rabbit articular chondrocytes in primary culture, and this IL-1-mediated production of proMMP-9 is greatly augmented by cyclooxygenase inhibitors such as diclofenac and indomethacin, whereas the constitutive production of proMMP-2 (progelatinase A) is not modulated by IL-1 and/or cyclooxygenase inhibitors. Solutions in N,N-dimethylacetamide (DMAC)-LiCl were prepared from two different pulps (sulphite pulp from softwood and cotton linters) in different ageing states. The aim of this paper was to further investigate these relationships.

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The role of pharmacogenetics and advances in gene therapy in the treatment of diabetic retinopathy. The uptake of small-sized molecules and external fluid through the plasma membrane is a localized process.

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Varus osteotomy was the best procedure for hip subluxation while posterior iliopsoas transfer, either alone or in combination with a varus osteotomy, was of questionable value. This classification is important because it helps occupational therapists know the full extent of the dysfunction through understanding the underlying pathology. We used two simple techniques for creating a uniform periumbilical incision. Infections occurring after discharge were not actively surveyed. High preceding PA and pulmonary capillary pressures lead to a non-inflammatory leak of the alveolar-capillary barrier with egress of red cells, plasma proteins and fluid into the alveolar space.

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Parallel changes in dopamine D2 receptor binding in limbic forebrain associated with chronic mild stress-induced anhedonia and its reversal by imipramine. To investigate the cause of osteomalacia following biliopancreatic diversion(BPD) surgery for obesity. Dynamic enhanced MRI is a reliable method to evaluate tumor response to neoadjuvant chemotherapy in breast cancer. Accelerometry was used to obtain objective measures of physical activity.

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The phase lead of MFV before CPP(F) is a mathematical and physiological consequence of the relation the input variable (CPP(F)) and the manipulated variable (cerebrovascular resistance) that should not be taken as an indication of independent control of cerebral blood flow. Results indicate that basal skin doses (taken to be at a depth of 0.007 cm) are approximately 1 cGy h-1 per 3.7 X 10(-4) Bq cm-2 (1 rad h-1 per muCi cm-2) from 99mTc, 111In and 201Tl, implying that established limits may be approached under certain circumstances.

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Minimally invasive total hip arthroplasty has been successfully introduced in the past decade. RNA editing is a post-transcriptional process which essentially affects the transcripts of protein coding genes, but has also been found to modify non-coding transcribed regions, structural RNAs and intron sequences. This vector (pMY3) consists of the RK2 replicon, promoterless luxAB genes, the thr attenuator to block the transcription of RNA into the luxAB region, and multiple cloning sites for cloning of the fragment carrying promoter sequences.

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In light of these findings, ICF may be preferable for treatment of tibial fractures with high risk for compartment syndrome. Current treatments are often blunt tools used to ameliorate the most severe symptoms, at the risk of disrupting functional neural systems. This paper reports the immunocytochemical and biochemical evidence of a sodium influx stimulating related peptide (SIS-like peptide) in the brain of the leech Theromyzon tessulatum.

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We have reported that MtDef4 is transported into the cytoplasm of these fungi and exerts its antifungal activity on intracellular targets. Circular dichroism of the isolated N-terminal region showed a high content of alpha-helical structure. The patient and reference group showed the same performance pattern.

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The number of implantable cardioverter defibrillator (ICD) replacements is increasing, which adds to patient risk and costs. DAP-kinase is a tumor suppressor that mediates several cell death pathways, such as apoptosis and programmed necrosis. Three dimensional CT was very useful to reveal enlarged jugular foramen. Uncommon benign lesions of lower esophagus, diaphragm, and cardia. Both the comparisons between the independent groups and the results from the individual patients followed in different phases of the disorder indicate that patients in the depressive phase have a tendency to decrease in maximum amplitude when stimulus intensity is increased (reducing).

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Elevated Faecal Calprotectin Does Not Differentiate Between Inflammatory Bowel Disease and a Juvenile Polyp. Since these alterations have been reported by different groups on different tumors and cell lines, the complete repertoire of genetic alterations for any given tumor sample remains unknown. Glycogen was measured in the 21-day-old embryo and one-day-old poult.

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Enhancement of the radiosensitivity of two human tumour cell lines by hexamethylene bisacetamide. Aloe exudate: characterization by reversed phase HPLC and headspace GC-MS. Doxycycline or erythromycin was more effective than penicillin or ceftriaxone in killing B.

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Here, we report that ERK2 activated by its upstream kinase, MEK1, represses Stat3 transcriptional activity induced by Src or Jak-2. A modified nasal tamponade with foam rubber protection in epistaxis Effects of cryopreservation of DNA synthesis in the inner cell mass of in vitro matured/in vitro fertilized bovine embryos frozen in various cryoprotectants. Necrotic neurons with pyknotic nuclei and highly eosinophilic cytoplasm were also found in affected ganglia.

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Laryngeal receptors are sensitive to expiratory concentrations of CO2. MECHANICAL MODELING: A mechanical model was used to simulate a human lens in both the accommodated and unaccommodated state to demonstrate changes in the mechanism of accommodation with age. In contrast, zinc generally potentiated the membrane responses to quisqualate or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and often did not affect the response to kainate.

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MAXIMUM VARIANCE LINEAR COMBINATIONS FROM PHENOTYPIC, GENETIC, AND ENVIRONMENTAL COVARIANCE MATRICES. This study investigates whether so-called super-resolution reconstruction methods can increase the resolution in the slice selection direction and, as such, are a viable alternative to direct high-resolution acquisition in terms of the signal-to-noise ratio and acquisition time trade-offs. The model is shown to reduce to the well-known macroscopic theories in appropriate limits, including compressible Navier-Stokes and wave equations. We have developed a small diameter, three-layered composite vascular scaffold which consists of electrospun fibers and physically-crosslinked hydrogel with copper wire-induced grooves by combining the electrospinning and dip-coating methods. Combined findings of CT-guided percutaneous cutting needle biopsy and CT are useful in first-line investigation of diffuse pleural thickening.

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A computationally efficient formal optimization of regional myocardial contractility in a sheep with left ventricular aneurysm. The propositus and her daughter, both with severe osteosclerosis, showed spinal canal stenosis, but her son, whose osteosclerosis was moderate, did not. If vinorelbine is preferred because of its toxicity profile, the additional effectiveness of cisplatin added substantial benefit at an acceptable cost.

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Autonomous thyroid nodules are conventionally treated by surgery or radioiodine. While female sexual dysfunction is a frequent occurrence, characteristics in infertile women are not well delineated.

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Heterogeneity offers the potential to observe a relation across study populations and circumstances. The component parallel to the layer normal is shown to be 2.1 times larger than the component within the layer. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Therefore, the present study aimed to gain further insight into the pathophysiology of this syndrome and to examine easily accessible clinical parameters that can improve therapy selection. The higher level phylogenetic relationships within the avian feather lice (Insecta: Phthiraptera: Ischnocera) are extremely problematic.

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The Cp:Cs ratio was found to vary much more between individuals than within an individual. The efficacy of conventional treatment (CT) in 20 controls was compared to that of heparin chronotherapy (HC) in 40 patients with chronic pyelonephritis.

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The good performance of this device can be explained by a combination of high shear rate, centrifugation of red cells and platelets away from the membrane and large secondary flows. Both monoclonal and polyclonal antibodies were generated against a C-terminal peptide of the rat rod channel. To elucidate the structural difference, supported HPA catalysts are characterized using a variety of techniques, including (31)P magic angle spinning nuclear magnetic resonance, and are shown to contain a range of species on both mesoporous and conventional zeolites. This laboratory has demonstrated that the longitudinal muscle/myenteric plexus (LMMP) preparation manifests pleiotropic responses to opioid agonists.

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In this study, cloned canine IL-6 cDNA was used as a molecular probe to study the regulation of IL-6 in an awake canine model of myocardial ischemia and reperfusion. Limit of agreement, concordance and intraclass correlation coefficient were used to evaluate the agreement.

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Several local optimization algorithms are used to infer the haplotype of each individual and determine the linked regions based on the inferred haplotype data. Patients took cisapride 5 mg thrice daily for 1 to 4 weeks (lower dose stage), followed by 10 mg thrice daily for another 1 to 4 weeks (higher dose stage).

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We assume that the differences in catecholamine excretion can contribute to the sex-and age-related differences in incidence of cardiovascular diseases, such as hypertension and coronary heart disease. Paternal deletion of 15q11-q13 and maternal uniparental disomy (UPD) of chromosome 15 are the main causes of Prader-Willi syndrome (PWS). The mitotic index was found to be greatly reduced in the intestinal crypt cells of ground squirrel during bout of hibernation. These results indicate that not only MM-GSH and MM-Cys but also MM-CysGly may play important roles in the intestinal reabsorption of methylmercury during its enterohepatic circulation.

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Note on objectives of psychological assessment procedures and the value of multidimensional questionnaires and inventories. Even though no single pharmacological agent or treatment protocol has been identified that prevents or reverses this deadly complication, a number of promising intervention strategies are being employed in the critical care setting.

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Susceptibility to test agents was assessed by disk diffusion and broth dilution techniques with criteria established by the National Committee for Clinical Laboratory Standards. Serotonergic pathway genes and subtypes of alcoholism: association studies. In addition, there has been hope that such lines might play pivotal roles in CNS gene therapy and repair. It is known that rotator cuff tears are sometimes accompanied by joint destruction.

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In mild neuropathies, in which nerve fibers are damaged uniformly, testing the whole length of a nerve with this method may be beneficial in detection of a mild conduction abnormality. Comparison of four methods for the determination of MIC and MBC of penicillin for viridans streptococci and the implications for penicillin tolerance. The size and surface plasmon resonance property of the gold nanoparticles were successfully controlled with this strategy.

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The 5-O-phosphonomethyl analog of ATP (ATPc) and its interaction with different enzymes, catalysing synthesis of C-O-, C-S-, C-N- and C-C-bond were investigated. Mammography and physical examination are currently the most commonly utilized screening methods for breast cancer. Aphidicolin was used to synchronize HeLa cells at the beginning of S-phase and S-phase progression followed on removing the drug. The techniques of the jackknife, balanced repeated replication (balanced half-samples), and the bootstrap are described, and the properties of these methods are summarized.

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We have examined the possibility that defective baroreflex function may contribute to the hypertensive effect of a high dietary sodium intake. The development of interstitial tumor infusion of macroaggregated albumin (MAA) followed by colloidal chromic phosphate 32P has overcome solid tumor obstacles in 47 patients with nonresectable pancreatic cancer in a Phase I dose escalation study. Recombinant human bone morphogenetic protein-2 (rhBMP-2) is responsible for multiple different signaling processes including positive effects on bone formation and fusion. Membrane active compounds that affect the shape of cells and cellular organelles. Observations on diagnostic kits for the determination of calcium in serum.

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Use of the omentum in the treatment of moyamoya disease is now widely accepted, and, especially in patients with ischemic symptoms of anterior or posterior cerebral artery distribution, omental transplantation or other indirect revascularizations are indicated. External applications result most frequently in contact eczemas and therefore often require preventive patch tests.

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Characterization of melanin concentrating hormone in teleost hypothalamus. The respective ratios of the amount of secreted APP to that of cellular APP for the mutant and wild forms were 0.11 and 1.01. Management of bone in the patient before, during, and after treatment for oral cancer.

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Although recent therapeutic developments for patients with pancreatic cancer have provided survival benefits, the outcomes for patients with pancreatic cancer remain unsatisfactory. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Doxorubicin (DOX) is one of the most effective anticancer drugs. Quiescent and tumor cells share the ability to evade irreversible cell fates.