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Clarazole (Ketoconazole)

Clarazole is only found in individuals that have used or taken this drug. It is a broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients. [PubChem]Clarazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol. This results in inhibition of ergosterol synthesis and increased fungal cellular permeability. Other mechanisms may involve the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Clarazole can also inhibit the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone.

Other names for this medication:
Ketoconazole, Nizoral, Akorazol, Arcolan, Arcolane, Asquam, Biogel, Clarazole, Conazol, Daktagold, Daktarin, Dezor, Diazon, Dikoven, Eumicel, Extina, Funginoc, Fungoral, Ilgem, Kenazol, Kenazole, Ketazol, Ketokonazol, Ketolef, Ketovid, Ketozal, Liondox, Lizovag, Micoral, Micosin, Muzoral, Mycoderm, Noell, Orifungal, Oronazol, Panfungol, Perative, Phytoral, Pristinex, Tiniazol, Tinuvin, Xolegel, Yucomy, Zoloral,

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The effect of home cage environmental stimuli on learning and the effects on retention of the presence or absence of these familiar contextual training stimuli during the retention test (Experiment 1) or during the retention interval (Experiment 2) were examined using 10-day-old rats, a multidirectional active avoidance task, and a 30-min retention interval. Angina severity predicts worse sleep quality after coronary artery bypass grafting. The pathology, nodal involvement and tumour vascular invasion were predicted by computerized statistical classification of the proton MRS spectrum from a fine-needle aspirate biopsy taken from the primary breast lesion. The threshold tone decay, absence of stapedius reflex, reduced speech discrimination and ERA findings with electric response decay and synchronization disorders within the brain stem are particularly significant.

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This study using simultaneous Holter and continuous glucose monitoring demonstrates that prolongation of QT interval can occur with hypoglycaemia in an ambulatory setting in people with type 1 and type 2 diabetes treated with insulin. The permeability coefficient was highest for di-cation, followed by mono-cation, positively charged, uncharged and negatively charged zwitterions. Most failure to complete the HPV vaccine series occurred because providers expected parents to make appointments while parents expected to be reminded. The pulsatile secretion of GH was evaluated by Cluster and DESADE analyses.

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To examine the type and frequency of preservative use in cosmetics sold in Thai markets in metropolitan Bangkok, Thailand. These studies are presented, as is an analysis of the finger flexor tendons as they pass through the carpal tunnel. Together these results provide a plausible explanation for how male and female moths, and maybe other insects, fly successfully upwind in an odor plume and locate the source of odor, using a surging-casting, phasic-tonic response to the onset and disappearance of each odor strand. Recent attention has focused on the effects of particulate exposure on cardiac autonomic control. Two hundred consecutive patients undergoing resection surgery of the lung during 1999 were retrospectively reviewed to define prevalence, type, clinical course and risk factors for postoperative supraventricular arrhythmias (SVA) with particular reference to atrial fibrillation or flutter (AF).

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MINUTES of the 1953 sessions of the House of Delegates, Iowa State Medical Society, Des Moines, Iowa-April 26-29, 1953. It is important for clinicians to make accurate, timely, safe and effective decisions with regards to drug use in the patient.

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Significant differences were found between existing and required levels of knowledge regarding all eight practice management tasks, particularly legal and ethical issues and marketing and accounting. Hemorrhagic diseases due to deficiency of a new coagulating factor and their differential diagnosis from hemophilia Comparative analysis of inhaled particles contained in human bronchoalveolar lavage fluids, lung parenchyma and lymph nodes. In the present study, the spinal canal diameters were measured in young subjects in whom degenerative changes have not yet become significant. Both GABA and its synthesizing enzyme, L-glutamate decarboxylase (GAD), are also present in the insulin-secreting pancreatic beta cells, in which its physiologic role is unclear.

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Global expression changes of constitutive and hormonally regulated genes during endometrial neoplastic transformation. A case of pharyngeal tuberculosis secondary to pulmonary tuberculosis is reported. Osteophytosis of the knee: anatomic, radiologic, and pathologic investigation.

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There is still no consensus on the treatment of elevated serum cholesterol in patients with a renal transplant. Sections from the cervical, midroot, and apical areas were examined. Insulin glucose therapy can correct hyponatraemia and renal sodium retention in burns, sepsis and circulatory failure.

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Neurotrophic factors rarely influence only a single target neuronal population, hence broad delivery of neurotrophic factors to the nervous system may results in effects on multiple non-targeted neuronal populations. In a study of the presence of melatonin in rat cochlea, a day-night rhythm of melatonin in cochlea was observed. Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity. Naloxone reduces the effects of chlordiazepoxide on punishment and on acquisition of differential reinforcement of low rates of response. In this respect the evaluation of GH secretion by means of tests that can explore the physiological pathways involved in the hormone output appears important.

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The difference between GAT and DCT intraocular pressure (dIOP) was calculated. From 65 studies identified, there seems to be no standard therapy for advanced biliary cancer. A patient is presented who illustrates the occasional difficulty of this diagnostic question.

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Mobilization of bone marrow granulocytes by glucocorticoid or endotoxin administration was not inhibited by intoxication, nor did it prevent the endotoxin-induced shift of granulocytes from circulating to marginal pool. Pressor and depressor factors in the pathogenesis of stenocardia in hypertension

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The incidence of adverse effects was very low even at the highest dose, 4 mg. Potential neurotrophin sources and cellular localization in spinal cord are largely undefined.

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The chicken liver enzyme also catalyzes the bicarbonate-dependent phosphorylation of fluoride ion. In the second group of the amphiphilic compounds tested, amine oxides, no effect of the length of the alkyl chain upon the studied activity was ascertained.

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The purpose of this study was to elucidate the changes in the posterior extensor muscles 10 years after whiplash injury. Functional homology between the sequence-specific DNA-binding proteins nuclear factor I from HeLa cells and the TGGCA protein from chicken liver. Those with multiple NMSC need more careful follow-up, and possibly more frequent examinations, because they are at greater risk. Diversity and abundance of resupinate thelephoroid fungi as ectomycorrhizal symbionts in Swedish boreal forests. No contralateral ACL intact knee developed degenerative OA changes.

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This combined computational and empirical method focuses on the interplay between a computational model and the appropriate neurological, neuropsychological, and speech and language data, the whole couched in connectionist mechanisms that map naturally to what is known of the neurophysiological structure of the brain. A theoretic model using the concept of systolic transmural nonuniform wall thickening was applied to develop a concentric two-shell geometry allowing evaluation of the mechanics of circumferential midwall fibers.

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With increment of VT evoked by rebreathing after hyperventilatory apnoae TI at first were increased. Here we demonstrate that the activity of Gis1 is negatively modulated by proteasome-mediated limited proteolysis. Fragment Bb is an activator of the alternative pathway of the complement system.

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Patients without complications can be discharged to the care of their optometrist on the first day following cataract surgery. Renal arteriovenous shunting in rejecting allograft, hydronephrosis, or haemorrhagic hypotension in the rat.

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The antilesion actions of anticholinergic agents on ethanol-induced injury in rat stomachs: the importance of gastric vascular integrity and tonicity. Despite supervised and appropriate anti-TB chemotherapy, the size of the abscesses paradoxically increased, accompanied by clinical deterioration at 1 month. In addition, these findings help to explain why males gestated in 10L and raised in 14L exhibit accelerated testicular development in the first 2 months of life compared to males gestated in 16L and transferred to 14L after birth.(ABSTRACT TRUNCATED AT 400 WORDS) We evaluated 26 (9 typical, 17 atypical) patients with mainly active-unstable CIDP using clinical and immunological examinations (enzyme-linked immunospot assay ELISPOT, fluorescence-activated cell sorting FACS) in comparison to 28 healthy, age-matched controls (HC). Both tumor cell types colonized the first organ encountered after injection.

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The relationship of intracellular iron chelation to the inhibition and regeneration of human ribonucleotide reductase. MetS was defined according to the National Cholesterol Education Program (NCEP) criteria.

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Molecular alignment dependent electron interference in attosecond ultraviolet photoionization. Awareness of the harmful effects of smoking tobacco can help dental professionals become more motivated to comply with current recommendations for smoking cessation in order to improve the oral and general health of the public. Such a model creates the opportunity of using group-based harmonic analysis (e.g., convolution calculus) to deal with problems concerning the truncated icosahedron. The incorporation of oats into a gluten-free diet provides high fiber and vitamin B content, increased palatability, and beneficial effects on cardiovascular health.

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This review discusses the structural bases of receptor binding, specificity, and activation in each of these systems. This intersection always occurred in a relatively small band-shaped zone under the central third of the epiphyseal scar. The compound bound to HSA with reversible and moderate affinity which explained its easy diffusion from circulatory system to target tissue.

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Hand pulling forces were measured using a six-axes force sensor. Molecular typing of Borrelia burgdorferi from Lyme disease patients by PCR-restriction fragment length polymorphism analysis.

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Collagen type II composition of the fibrocartilage was markedly altered by the presence of fibrovascular tissue which labelled only for collagen type III. RPT is a peer-mediated classroom intervention based on a developmental-ecological model. Comparison of extraction solvents and conditions for herbicide residues in milled rice with liquid chromatography-diode array detection analysis (LC-DAD). Some of the most difficult and challenging issues that will be raised during a pandemic will be ethical in nature. Runaways were significantly more likely than non-runaways to have experienced severe sexual abuse, to have used alcohol and drugs, and reported problem substance use behavior, higher levels of emotional distress, more sexual partners, and they were more likely to have a sexually transmitted infection (STI).

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These observations suggested that chronic Cr exposure could produce potential prostate injury and the nonspecific inflammation at least might be one of the reasons to explain the elevated concentration of tPSA in chronic occupational chromate exposed workers. The effect of botulinum toxin injections to the calf muscles on freezing of gait in parkinsonism: a pilot study. The geometric mean concentrations of seroconverters at Months 6 and 8 were significantly greater for the 10-micrograms group compared with the 5-micrograms group. Primary Health Care had a predominant place in early detection of risk practice and in the areas of prevention, education and information.

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The molecular dynamics were investigated by using broad-band dielectric spectroscopy. Lipophilicity and catalysis of photophosphorylation I Sulfonated phenazonium compounds are ineffective in mediating cyclic photophosphorylation in photosystem-I-subchloroplast vesicles.

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Efficacy and safety of a seven-day, transdermal estradiol drug-delivery system: comparison with conjugated estrogens and placebo. To test the applicability of AGII-Bar use in a weed-infested field, a controlled experiment including more than 450 plants inoculated with this construct, was performed. The data obtained are consistent with the view that BDZs can augment the affective response to heroin in laboratory animals. Replacing the YY1 binding site with an intrinsic DNA bending sequence mimicked this transcription repression.

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Reverse transcriptase-polymerase chain reaction (RT-PCR) revealed that GDNF transcription in the spinal cord began to increase within 30 min after injury and peaked within 3 h. The model uses a Markov random field to compute the behaviour of coextensive topographic neural maps of retinotopy and velocity.

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Usefulness of laparotomy in the differential diagnosis of hepatic cystic degeneration diagnosed as hepatic echinococcosis Previously, we have determined the effects of restraint stress on the regulation of corticosteroid receptor genes in the brain and pituitary of male and female rats. Angiography with selective embolization is a safe and effective alternative to surgical ligation for control of hemorrhage in patients with squamous cell carcinoma of the head and neck. Requirement for a protein with cysteine oxidase activity and gamma-cystathionase.

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