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The model featured repeated exposures to situational reminders of a traumatic stress, which consisted of a brief electric shock, and included assessment of two behavioral parameters and the startle reflex. It is confirmed that berberin could raise insulin sensitivity of high fat diet rats similar to metformin. Cloning, sequencing and tissue-distribution of mouse 11 beta-hydroxysteroid dehydrogenase-1 cDNA. The reduced firing rates associated with DI has been hypothesized to reduce dopamine release and thus psychotic symptoms. In this study, we prospectively investigated the efficacy and toxicity of a sequential treatment with three cycles of vindesine-ifosfamide-platinum (VIP) induction chemotherapy, followed by daily cisplatin-sensitized radiotherapy.

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Based on main effects and interactions of these variables, we established an individualized age- and gender-adapted scoring system to improve prognostication in MDS. A1 vessels were unresponsive to all doses of ACH at all time points. The number of temporal contacts between sLNvs and DN2s peak before dawn. Hypophosphatemia occurs in cats after renal transplantation and does not affect survival. Excess mortality was greatest in the first year after entry, and decreased thereafter.

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Our results show a close association between CD147 and MCT1 and MCT4 expressions in human cervical cancer and provided evidence for a prognostic value of CD147 and MCT1 co-expression. Primary CNS lymphoma in association with IgM kappa paraproteinaemia and peripheral polyneuropathy: a case report. The distribution of retrogradely labeled cells after unilateral high spinal cord injections suggests that ascending supraspinal fibers are derived from neurons in the following areas: in the cervical intumescence in most areas of the spinal gray, particularly ipsilaterally, in thoracic and lumbar segments, in deeper situated areas, especially contralaterally. The development of a treatment protocol for patients with chronic radiation-induced rectal bleeding. (3) Small multipolar interneurons could be identified in the retronodal ganglion and within right and left bundle branches.

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Purification and properties of citrate synthase from Acetobacter europaeus. In order to examine the relationship between biological activities and the cell wall content, the murein type and the teichoic acid of the cell wall from five strains of bacteria were studied. Although this new type of sequence data has the potential to revolutionize our understanding of infection dynamics, quantitative analysis is complicated by the unique biology and high diversity of BCR sequences. The objective of this study was to investigate a new technique for tracheal puncture during percutaneous dilatational tracheotomy (PDT). cor consist of secretory cells that conform to typical secretory cell morphology.

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Comparison of different platelet transfusion thresholds prior to insertion of central lines in patients with thrombocytopenia. Towards do-it-yourself planar optical components using plasmon-assisted etching. The PIC of D5S436 is high in Chinese individuals, so it could be used as a genetic marker of asthma in Chinese and might be useful in the gene diagnosis of asthma. Twenty patients with gastric cancer and 13 patients with breast cancer were studied. Neonatal exposure of the female rats to testosterone caused a dose-dependent increase in the amounts of prolactin released to levels significantly (P less than 0.01) higher than those observed in male animals and in untreated females.

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In addition, diseases that cause intrahepatic cholestasis such as primary biliary cirrhosis, primary sclerosing cholangitis, hepatocellular diseases and a variety of miscellaneous causes including drugs that may cause cholestasis are discussed. Small (10 nm) depth patterns promoted cell adhesion without noticeable differentiation, whereas larger depth patterns (100 nm) elicited a collective cell organization, which induced selective differentiation into osteoblast-like cells.

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Altered spine morphology might underlie the cognitive deficits in neurodevelopmental disorders such as autism, but how different subtypes of dendritic spines are selectively maintained along development is still poorly understood. The first find of the feather mite from Apionacaridae family (Astigmata: Analgoidea) on the passerines ( Passeriformes) Thus, the present methods shown in this study will provide opportunities to conduct further molecular analyses on the molecular developmental bases of nasus formation during soldier differentiation in higher termites. Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury.

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In this study, BMP2 mRNA was detected by qRT-PCR and data showed that it was upregulated in NPC compared with non-cancerous nasopharynx samples. White House commission examines research on complementary cancer therapies. In this study early operation was elected in 61 per cent of those patients with reflux in association with total duplication.

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The aim of the present study was to clarify the relationship between the depth of melanin in the skin and the color variation exhibited, and to objectively estimate the 3-D location of melanin in the pigmented skin lesions from dermoscopic images. Prevalence and characteristics of central nervous system involvement by chronic lymphocytic leukemia. At these concentrations salmeterol is not cytotoxic, nor does it act as a scavenger of superoxide. In addition, new data from explants of the OVP II, a later version of the Omniflow, are also described.

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Compared with men, women reported worse pain intensity, greater pain-related interference with function, and more disability days due to pain. Preoperative thin-sliced bone CT and steady-state magnetic resonance images revealed a bone defect at the middle clivus and a collection of CSF fluid from the clival fistula in the sphenoid sinus.

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The first patient was a 4-year-old boy who presented with neck pain after falling off a trampoline. High-resolution Quantitative Computed Tomography Demonstrates Structural Defects in Cortical and Trabecular Bone in IBD Patients. Complexes of a modified low-molecular-weight heparin with protamine are predominantly cleared by a macrophage scavenger receptor-mediated process in rats. Two Russian brothers presented with recurring benign facial bone tumors and progressive limb bowing. Pseudomonas aeruginosa carriage in the gastrointestinal tract is uncommon in healthy children.

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The megavoltage therapy of urogenital tumors with the 43 MeV betatron. Contrasts based on the work schedules, patient focus, professional autonomy, opportunity for professional development, and required skills are considered. The postoperative monitoring of intracranial pressure in patients in the acute period of aneurysmatic hemorrhage Cortisol treatment increased the responsiveness of the catecholamine release process to low doses of the cholinoceptor agonist carbachol. Experience with objective evaluation of the action of cimetidine--a blocker of histamine-H2 receptors--in patients with peptic ulcer of the duodenum

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Reports were reviewed if they included substance abusers or related tridimensional traits to substance use measures. The poor water solubility of many candidate drugs remains a major obstacle to their development and clinical use, especially for oral drug delivery.

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Membrane properties and synaptic potentials in rat sympathetic preganglionic neurons studied in horizontal spinal cord slices in vitro. Though Senegalese mtDNAs display typical African features (presence and frequency of HpaI morph 3 and high incidence of AvaII morph 3), the distribution of MspI and AvaII patterns markedly differentiates Senegalese from the others. Spinal dural arteriovenous fistula associated with syringomyelia. By using circular dichroism and UV-visible spectroscopy, the d(CCC) flanking sequences were demonstrated to improve the hemin binding affinity to G4s instead of increasing the parallel G4 formation, which might explain the enhanced DNAzyme activity. Ligation of B cell CD40 by CD154 expressed on activated T cells stimulates B cell proliferation, differentiation, isotype switching, upregulation of surface molecules contributing to antigen presentation, development of the germinal center, and the humoral memory response.

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Alternative splicing represents an important molecular mechanism of gene regulation in physiological processes such as developmental programming as well as in disease. At baseline, examiners questioned each participant about their toothbrushing habits, and at subsequent examinations, this information was obtained using a self-administered computer-based questionnaire. Analysis of common foods in the African-American culture are listed for reference, along with a glossary of ethnic foods.

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The disease is of potentially major public health significance, particularly in the northern and coastal savannahs, and requires the design and implementation of a control programme. The exposure to radiation is about the same as that caused by a (spiral) CT. Pretreatment with DEM significantly attenuated both microvascular leakage and neutrophil infiltration. MT-1 mRNA in BAT increased after 6 h, and the mRNA level after 24 h was equivalent to that in liver 6 h after injection of rats with 10 mg Zn/kg.

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The age distribution over time showed that the proportion of cases in children is still the largest, although the proportion of notifications of adult cases increased slightly over time. The effect of Shh on cell migration was reversible and was not accounted for by alterations of the specification, delamination, proliferation, and survival of NCCs but could be essentially attributed to a decreased cell-substrate adhesion mediated by integrins. Female Wistar rats were subjected to 2-week chronic unpredictable stress induced by random stressors and treated with venlafaxine orally at a dose of 5 mg/kg twice a day. Until now systematic investigations of extracellular matrix components in preneoplastic lesions and early stages of lung cancer are lacking. In a retrospective review of 23 BLT patients, we hypothesized that BLT without CPB injures the first transplanted lung measured by acute and late graft dysfunction compared to the second transplanted lung.

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The present study aimed to investigates the contact lenses of patients with keratitis for pathogenic free-living amoebae. To characterize the pregnant women, their age, number of gestations, and blood pressure values were used. The effect of sFlt-1 protein on cell growth and VEGF expression in Lovo cells were investigated by MTT and ELISA. Imposition of financial restrictions that bars access to a therapy with known benefit is a questionable practice. In two recent cases, rural hospitals contacted our centre for assistance with complex ethics cases.

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Pyelocalyceal diverticulum: the imaging spectrum with emphasis on the ultrasound features. Between 1970 and 1989, 185 patients with SCCa of the tonsil were seen at our institution. The WHO-5 was shown to be a measure with high reliability, validity and sensitivity to change, for use with patients who have affective or neurotic primary diagnoses. It provides some insights into potential solutions to the issues and will be of interest to both trainees and those involved in their education.

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Its activity is based on its antioxidant and antiglycating action that, in addition to heavy metal chelation and pH-buffering ability, makes carnosine an essential factor for preventing neurodegeneration and accumulation of senile features. Investigation of the genes involved in antigenic switching at the vlsE locus in Borrelia burgdorferi: an essential role for the RuvAB branch migrase. We sought to assess the outcome of asymptomatic patients with very severe aortic stenosis.

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The right ovary was moderately enlarged and incompletely twisted. Affinities of trimebutine (TMB) and N-desmethyl trimebutine (NDTMB) for mu, delta and kappa opioid receptor subtypes have been examined using specific 3H-ligands and guinea-pig membrane. Serine-to-alanine amino acid substitutions in this region modulate the association of p40 with Rel proteins in vitro and abolish p40-mediated inhibition of DNA-binding by c-Rel. Leveraging mammalian pharmaceutical toxicology and pharmacology data to predict chronic fish responses to pharmaceuticals. We previously described a conserver nasal cannula (CNC) which stores oxygen during exhalation for delivery during subsequent inspirations.

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Pneumocystis remains an important cause of fatal pneumonia (PCP) in HIV patients and other immunocompromised hosts. PSTPIP1 binds to pyrin and mutations in pyrin result in familial Mediterranean fever (FMF), a related autoinflammatory disorder. Treatment of angina pectoris with dipyridamol (Curantyl, Germed) Mortality and causes of death in the WHO Multinational Study of Vascular Disease in Diabetes.

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In our in vivo expression technology screen, priA gene was induced in vivo when Helicobacter pylori infects mouse stomach. Short-course chemotherapy of pulmonary tuberculosis: a new approach to drug dosage in the initial intensive phase.

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Pharmacokinetics of cytosine arabinoside in acute myeloid leukemia. Beta-hydroxy-beta-methylbutyrate ingestion, part II: effects on hematology, hepatic and renal function.

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These results suggest multiple benefits in restoring ABCG2 function. This study suggests that pregnant women being physically active have less weight gain during pregnancy. Medial temporal lobe (MTL) lesions typically produce retrograde amnesia characterized by the disproportionate loss of recently acquired memories. Genetic toxicology and risk assessment of complex environmental mixtures. These findings were supported by analyses using a second comparison group.

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On the other hand, we found no evidence that manipulation of BMP signaling, either positively or negatively, altered the expression domains of Xnr-2 and Xbra. Results from the present study indicate that the gene encoding the neuronal-specific gamma subtype of protein kinase C (PKCgamma) influences both ethanol consumption and behavioral impulsivity, a personality characteristic associated with Type II alcoholics, in a pleiotropic manner. Dorsalis pedis arterialized venous flap for hand and foot reconstruction.

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Progress continues to be made on integrating information obtained from reductionist models into more complex in-vivo animal models and where possible in human studies. There is a relationship between poverty, unemployment, poor housing, informal settlements and rodent infestation.

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We have exposed cultures of PC12 cells to uniform DC electric fields following the addition of NGF. A method for the investigation of the effects of outsole modifications in therapeutic footwear. Treatment of liver metastases, an update on the possibilities and results. The author believes that digestive tract bleeding easily occurs with consciouslessness, great quantity of intracerebral hematomas into ventricles and injury of brain stem.

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High levels of focal interleukin-8 message were found to be expressed in the upper epidermis by keratinocytes and, most importantly, neutrophils themselves. actinomycetemcomitans strain Y4 induced bone resorption in mouse organ culture. The use of developmental screening tests by primary-care pediatricians.

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Involvement of mitochondria in changes in fluorescein excitation and emission polarization spectra in living cells. The authors have previously reported that opioid receptors are functionally coupled to extracellular signal-regulated kinase, a class of the mitogen-activated protein kinase.

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The role of the mucosal immune system in the generation of circulating tolerogenic ovalbumin (OVA) moieties has been investigated after a single feed of the protein. Immunomonitoring of human responses to the rVSV-ZEBOV Ebola vaccine. The association rate constant for scFv::strep tetramers was higher than those for scFv monomers and dimers.

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Perceptions and experiences of women seeking treatment for obstetric fistula. The three genes encoding these proteins, plcA, plcB, and plcC, are located at position 2351 of the genomic map of M.

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The growth of T 124958-R was enhanced by the administration of tamoxifen to mice. To explore the value of pulse oximetry for diagnosing obstructive sleep apnea hypopnea syndrome (OSAHS) and evaluation of the effect of the continuous positive airway pressure (CPAP) therapy.

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Both pathways frequently undergo a variety of activating alterations, including oncogenic mutations, amplification events and loss of tumor-suppressor genes that are thought to confer aggressive growth properties and enhance survival on neoplastic cells. (2) Parents were asked to compare overall status of their child, relative to the period prior to using the vagal nerve stimulator, on a global rating scale.

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We show that the HSV-1 structural protein VP22 has the remarkable property of intercellular transport, which is so efficient that following expression in a subpopulation the protein spreads to every cell in a monolayer, where it concentrates in the nucleus and binds chromatin. Changes in pulmonary connective tissue proteins after a single intratracheal instillation of cadmium chloride in the rat. Gestational exposure to ethanol increased fetal resorption, and trophoblast apoptosis/necrosis, oxidative stress, DNA damage, and lipid peroxidation. We also prospectively investigated the response to interferon in five patients with HCV coinfection. The effect of dextran on cerebral function and blood flow after cardiac arrest.

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Although each country and region might proceed along their own line depending on local circumstances, some kind of general guidelines and recommendations at least at the European Union level would be urgently needed. Nuclear staining demonstrated chromatin condensation in NGF-deprived cells. The incubation of cells with exogenous arachidonic acid or ethanolamine did not reverse the inhibition of proliferation induced by CoA-IT inhibitor treatment.

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Beta-interferon-induced nephrotic syndrome in a patient with multiple sclerosis. One hundred thirty-two consecutive patients who had liver resection for colorectal metastasis at our hospital between 1980 and 1997 were studied. Qualitative assessments from the interviews and focus groups led us to expand from 15 to 32 symptom-specific items and from 4 to 10 functional impairment items.

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Localization to the nuclear periphery was found to dampen initial GAL gene induction and was required for rapid repression after gene inactivation, revealing a function for the nuclear periphery in repressing endogenous GAL gene expression. Impediments to change and their resolution in clinical practice. Natural adhesion between the levator aponeurosis and the subcutaneous layer in the upper lid is essential for an aesthetically pleasing double eyelid. MET value was calculated from resting EE and steady-state EE during activity. Thus, the results cast some doubt on the common assumption that increasing the population served by alternative modes of delivery such as HSOs and CHCs necessarily increases the level of disease prevention and health promotion activity.