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Cisplatin caused a dose-dependent increase in DNA cross-links 6 h after treatment. In addition, the rapidly turning over fraction of polymers is much larger in the UV254nm-resistant LY-S cells. Five diterpenoid alkaloids were elucidated as yunaconitine, crassicauline A, vilmorrianine C, lycoctonine and lappaconitine. Stimulus coherence influences sound-field localization and fusion/segregation of leading and lagging sounds.

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Patients with an increase of 190 ml or more in FEV1 after bronchodilator had less bronchial cartilage and less goblet metaplasia in bronchioles. Here, we present a research platform, WINCS Harmoni, which can measure in vivo neurochemical activity simultaneously across multiple anatomical targets to study normal and pathologic brain function. Analysis of the findings showed that although there was a high level of correlation between the two groups on opinions and attitudes on a number of issues, there were significant, important differences on others.

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The positivity rate of M genitalium infection in asymptomatic sexual-health clinic attendees is comparable with that of gonorrhoea or chlamydia, and, if evidence of pathogenicity continues to accumulate, a further assessment of the role of routine screening in this setting would be appropriate. Bcl-2, Bcl-x, and Bax are among the variety of proteins that have been described as being involved in the regulation of apoptotic cell death.

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Moreover, a large subset of priming-specific genes showed an inverse regulation compared to their regulation upon challenge only. To study the regulation of cell cycle events after asymmetric cell division in Caulobacter crescentus, we have identified functions that are required for DNA synthesis in the stalked cell produced at division and in the new stalked cell that develops from the swarmer cell 60 min after division. To determine the relationship between TFC measured by ICG and BNP serum level in patients with systolic heart failure (HF). Cytochemistry of nucleic acids and proteins in malignant cells of sarcoma 180 after treatment with the antitumour drug DL-sarcolysine. Effect of hemoperfusion with polymyxin B-immobilized fiber on plasma endothelin-1 and endothelin-1 mRNA in monocytes from patients with sepsis.

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In this paper, we propose a binary work mode in which RF sensors send the link states instead of raw RSS measurements to the BS, which remarkably reduces the amount of data delivery. The aim of the study was to characterise the population of drug abused pregnant women in Czech republic and chart their socioeconomic situation. These profiles become symmetric again at the straight section of the capillary.

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It is suggested that v-src requires a nuclear auxiliary function for transformation which is present in early-passage cells, particularly when these cells are derived from embryonic tissue, but is lost as cells approach replicative senescence. Cross-linking experiments suggested that the C-terminal shortened chaperone and the Fae/FanE hybrid chaperone were homodimers, as is the wild-type K88 chaperone. Review of HPLC methods and HPLC methods with mass spectrometric detection for direct determination of aspirin with its metabolite(s) in various biological matrices.

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It is concluded that delayed type hypersensitivity to flea antigen does not play a role in the pathogenesis of GSP. Here we demonstrate that CDC23, a protein known to be involved in sister chromatid separation during mitosis, is able to directly interact with SIN1. The fetal zone of the adrenal gland: its developmental course, comparative anatomy, and possible physiologic functions. This is the first linkage assignment of a dominant locus for mucocutaneous candidiasis. Private healthcare provision was included as an independent variable in several multivariate logistic and Cox proportional hazard regression models that assessed a range of outcome variables, encompassing treatment commencement delays, management and treatment outcomes.

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Moreover, oleic acid (OA) treatment, which does not induce ER stress in SW620 cells, led to activation of SREBP-2 and induced a target gene expression pattern similar to that of DHA-treated cells. Unlike their mammalian counterparts, the avian reoviruses exhibit the unusual property of inducing rapid and extensive syncytium formation in cell cultures, a cytopathic effect more commonly associated with enveloped virus replication. A double-blind comparison of the therapeutic efficacy of mesoridazine versus chlorpromazine. Extensive mutagenic analysis of TCR beta chain, including changing the charged amino acid residues and two tyrosine residues of the transmembrane region into hydrophobic amino acid residues, did not alter the ER retention and rapid degradation. Nayreen Daruwalla and colleagues describe the Centre for Vulnerable Women and Children, which serves clients coping with crisis and violence in the urban setting of Dharavi, Mumbai.

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Characterization of porins isolated from the outer membrane of Serratia liquefaciens. Mathematical modelling of respiratory syncytial virus (RSV): vaccination strategies and budget applications. Higher species richness was also associated with the warmer months.

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Measurement of reported pain of childbirth: a comparison between Australian and Italian subjects. The two top barriers perceived by respondents were lack of time to search for relevant evidence-based information and being able to make time during working hours to look for new information.

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However, both uniform spatial cell distribution and the pore size of the matrices are important to cell proliferation and morphological development in the seeded tissue scaffold. Therefore, selective apoptosis induction seems to be based on superoxide anion production by transformed cells, their spontaneous dismutation to hydrogen peroxide, and HOCl generation by a novel effector cell-derived peroxidase. Relationship between the induction of proteins in the HSP70 family and thermosensitivity in two species of Oryzias (Pisces). Paediatric antibiotic prescribing by general dental practitioners in England. Clinician judgments of functional outcomes: how bias and perceived accuracy affect rating.

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Our findings confirm that MRI can detect cerebral fat embolism with a higher sensitivity than CCT. Clinical and pharmacology study of chloroquinoxaline sulfonamide given on a weekly schedule. Pathological findings, diagnosis, and clinical management of the condition are discussed.

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In this report, we present a case with acute paraplegia who had thoracic and cervical intramedullary cavernous angiomas and normal cranial magnetic resonance imaging. Apparent diffusion coefficient value appears to be a promising parameter for detecting pancreatic cancer and evaluating the degree of malignancy of pancreatic cancer. p73 G4C14-to-A4T14 polymorphism and risk of second primary malignancy after index squamous cell carcinoma of head and neck. They emphasized differences in bioethical view between the Japanese and the Europeans and Americans, and a need to reform medical education in Japan. Short-term effects of thyroid hormones on lipogenic enzymes and 14C-acetate incorporation into various lipid classes: in vivo and in vitro studies.

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The dynamic intracellular distribution of nucleolar protein B23 in the interphase and mitotic cells of mammalian cultures A synthetic peptide (NR6) based on the phosphorylation site sequence was phosphorylated readily by NR kinase (NRk) in vitro. Structure of the catalytic core of the Tetrahymena ribozyme as indicated by reactive abbreviated forms of the molecule.

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Small bowel transplantation: current progress and clinical application. Since the HSV polymerase and its accessory factor (the products of the UL30 and UL42 genes) are unable to efficiently perform synthesis by strand displacement, it is likely that in addition to creating a hairpin primer, the AAV Rep protein also acts as a helicase for DNA synthesis. Family data demonstrate that these fragments segregate as Mendelian alleles. The DSI is also enhanced by sustained low-frequency (1 Hz) stimulation (5 min). An important part of succesful management of CDH is the referal of cases to a specialised center.

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Efficacy of topotecan treatment on an experimental model of transient evoked otoacoustic emissions. 4-Proline and 4-hydroxyproline analogs of arginine vasopressin: role of the proline substitution in the two beta-turns of vasopressin. Stricter criteria are needed to discriminate between hypertensives with and without the systemic developments that constitute the immediate source of risk to the hypertensives individual. Notwithstanding the small sample size, this study shows that drug-users practice high-risk sexual behavior more frequently. HIF-1alpha and VEGF could be used as biomarkers indicating tumors in advanced stage and independently implied poor prognosis in patients with CRC.

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Does ovarian surgery for endometriomas impair the ovarian response to gonadotropin? Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation. Isolation and characterization of two virulent antigens of Streptococcus dysgalactiae. CT fluoroscopy is an alternative to conventional fluoroscopy that could potentially help reduce the risk of injury by providing improved localization of the needle tip. Simultaneously the free iron quantity was decreased 2-fold as compared with the norm.

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Compound 2 was devoid of antitumor activity against P388 leukemia and C38 colon adenocarcinoma. We report a 15-year-old girl with this rare dermatosis who was successfully managed with daily calcipotriol, weekly topical ivermectin, and strict photoprotection. Ethical guidance from the British Medical Association (BMA) about treating doctor-patients is compared and contrasted with evidence from a qualitative study of general practitioners (GPs) who have been patients.

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Also, its lowers total (TC) and low-density lipoprotein cholesterol (LDL-C) in normocholesterolemic rabbits in a dose-dependent manner and inhibits cholesterol biosynthesis in fibroblast cultures. These observations have important consequences for biodiversity dynamics and conservation issues, current estimations of extinction rates and the relevance and definition of keystone species.

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The matrix substitution approach has similar performance to the current standard, but is simple and uses only a genotype covariance matrix, while the family-average method shows superior performance. In the latter part of the 20th century, significant advances have been made in the understanding of the emetic reflex. The constructed network is consistent with the current biological knowledge and reveals new insights about lung adenocarcinoma. for combination anaesthesia and naloxone, sarmazenil and yohimbine (0.03/0.3/2.0 mg/kg) i.v.

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A complete differentiation of subspecies lactis and cremoris in agreement with conventional phenotypic methods was achieved by S-PCR with a set of site-specific primer pairs (PR1, RM4, and F3) designed particularly from a deletion region found in subspecies cremoris, but not in lactis. Viral DNA synthesis in isolated nuclei from adenovirus-infected KB cells. Before this important technique is utilized for clinical treatment of disc degeneration, many challenges need to address including in all three principal components of tissue engineering, i.e., seed cells, signals and biomaterial scaffolds. Its primary application is to measure the size of a leg ulcer by scanning a laser displacement sensor over the affected area.

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A series of 3-acylhydrazono-4-hydroxycoumarins were synthesized via condensation of 3-acetyl-4-hydroxycoumarin with appropriate hydrazides. Recently, much attention has been drawn to the use of retrovirally mediated gene therapy using HTK as a new therapeutic approach for brain tumors. With the largest dose, an initial activation was followed by a state of EEG depression characterized by a high percentage of slow, high voltage waves. An overview of healthcare reform for the neurodiagnostic practitioner. A multidisciplinary assessment by both an orthopaedic surgeon and rheumatologist with review of the imaging by a radiologist is useful, as this condition is a diagnosis of exclusion.

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Moreover, baseline host and tumor tissue studies may enable the discovery of biomarkers predictive of activity. From these results, we conclude that contact sensitisation during the early stage of grafting skin not only produces suppression of ear swelling but also induces antigen-specific tolerance. In vivo inhibition of transcellular water channels (aquaporin-1) during acute peritoneal dialysis in rats.

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Cardiovascular risk factors as hypertension, diabetes, hypercholesterolemia or cigarette smoking were found in all cases. These predictions are supported by observations of variation between and within species. Additional TH-positive cell groups were found along the seventh nerve, within the medial longitudinal fasiculus, in the nucleus raphe pallidus, and in the pars caudalis of the spinal trigeminal nucleus. Simple assay of calcium dependency for virulent plasmid-bearing clones of Yersinia enterocolitica. Specimens from patients with a history of head and neck cancer, previous laryngeal trauma, or surgery were excluded.

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Infants searched the goal box and its rotational equivalent significantly more than would be expected by chance in the identical condition, showing that they were sensitive to the geometric configuration of the array of boxes. A new catheter for bronchospirometry which combines the advantages of the double lumen and single lumen catheters. The embolic, arrhythmic and anesthetic complications of DCC can be prevented if the known recommendations of performing the DCC are followed.

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Log10MoM distributions of ADAM12 and correlations with other markers were established. Follow-up PET studies in case of idiopathic REM sleep behavior disorder. Event-related brain activity associated with auditory pattern processing. Retrobulbar optic neuritis in a patient with acute type B hepatitis.

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In this study, surgically treated patients were followed and evaluated retrospectively for favorable functional outcomes. It is concluded that zinc level of studied cirrhotic patients is less than half of the normal range. A considerable volume of oil remains in the subsurface today despite 30 years of natural attenuation and 5 years of pump-and-skim remediation. Beginning on day 2 of menses, premenopausal women collected first morning urine samples every other day for a complete menstrual cycle.

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Expression of enzymatically active adenovirus DNA polymerase from cloned DNA requires sequences upstream of the main open reading frame. These include the need to carefully attend to the learning/performance distinction, to rely equally on synthetic as well as reductionistic thinking, and to avoid the seduction of simplicity. ERPs elicited from each consonant presented in the lists were subtracted from those of a control condition that was also applied to the participants. The breakdown of fibronectin was not observed with untreated bacteria.

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Neuroprotective effects of the complement terminal pathway during demyelination: implications for oligodendrocyte survival. Scattering, transport scattering, and absorption coefficients of solid, homogeneous phantoms and of aqueous suspensions of monodisperse quartz glass spheres were derived from measurements of time-integrated collimated transmittance and time-resolved diffuse transmittance. Asymmetric ruthenium-catalyzed 1,4-additions of aryl thiols to enones. Autoallergy in burns: an attempt to demonstrate burn-specific antigen in experimental thermal trauma. The good possibility of controlling the shape and size of vapor bubbles offers a wider range of new applications, especially in ophthalmic microsurgery such as erbium YAG laser vitrectomy.

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The diagnosis was established with contrasted abdominal CT scanning. Both during and between episodes of headache, the pupil on the symptomatic side dilated more slowly and less extensively in darkness than the opposite pupil, indicating that ocular sympathetic outflow was compromised in some patients. The properties of this cell line, which remains close to diploid, are similar to those of early prostate cancer cells, and it retains expression of many prostate-associated antigens, such as prostate-specific antigen (PSA). Since we are interested in the effect of these agents on neural structures within the avian basilar papilla (BP), we are concerned about any subtle changes that might result from the surgical procedure of columella removal alone. No membrane potential is induced at zero fixed charge density as occurs at a protein characteristic pH.

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After treatment with either guanosine diphosphate or carboxyatractylate alone, proton conductance was lower in HFE compared with LFE mitochondria. Benzodiazepine receptor antagonist (flumazenil) does not affect sleep-related breathing disorders. How the nurse practitioner manages the rheumatoid arthritis patient. Effect of low concentrations of fluorine administered with drinking water on the development of periodontium in white rat Antibody to hemorrhagic fever with renal syndrome viruses (Hantaviruses) in the United States.

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The aid of electron microscopy in the diagnosis of osteosarcoma of the bone (case report). In children, the isolation of a sexually transmitted organism may be the first indication that abuse has occurred. Sampling with filter paper--AgNO3 and colorimetric analysis remains a reliable technique. Philippe-Nicolas Pia (1721-1799), creator of the first-aid service to rescue drowned people

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We used this system to show that the ygbP, ychB and ygbB genes are essential in E. The evaluation of a dipstick test for Plasmodium falciparum in mining areas of Venezuela. These associations persisted for both sexes and in the younger as well as the older age groups, with the exception of cholesterol values for males and for those in the 50 to 74-year-old age group. Its effects on cellular gene expression were studied both during MV infection and in isolation, with C7 DNA cloned into a pKC4 expression plasmid.

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Iron binding to Azotobacter salinestris melanin, iron mobilization and uptake mediated by siderophores. Linkers, packages and pathways: new concepts in axonal transport. Our results suggest that the species isolated became adapted to processing conditions, and salt tolerance was species- or strain-dependent. Activation of bovine factor X (Stuart factor)--analogy with pancreatic zymogen-enzyme systems. Opiate addiction, similarly to addiction to other psychoactive drugs, is chronic relapsing brain disease caused by drug-induced short-term and long-term neuroadaptations at the molecular, cellular, and behavioral levels.

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Sensitive and efficient detection of thrombus with fibrin-specific manganese nanocolloids. The higher GLUT-1 expression level in the tumor lesion may partially explain the higher FDG accumulation in the tumor than in the inflammatory lesion. On the equilibrium of helical nanostructures with ordered mesopores.

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Requirements for kissing-loop-mediated dimerization of human immunodeficiency virus RNA. This process of progressive atrophy, which finally results in the total disappearance of the invaded host tissue, is considered to be caused mainly by the increasing pressure and competitive withdrawal of oxygen and nutrients by the invading and proliferating tumor cells. In this study, we investigated the changes of insulin and autophagy relevant signals of hypothalamus under diabetes mellitus.

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Zinc transporters (ZnTs) are responsible for transporting zinc from the cytoplasm to the extracellular space or to intracellular compartments. Migration of endothelial cells plays an important role during angiogenesis and the late remodeling phase of arteriogenesis. Effects of the antiprogesterone RU 486 on preterm birth in the rat. These changes probably reflect a generalised skeletal myopathy and provide further evidence of respiratory muscle dysfunction in patients with this disease. In this article, the dynamics is illustrated in detail in the case of blood flowing into a capillary tube by contact.

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In particular, these hormones could play a role in determining the higher dopaminergic activity that characterizes drug proned individuals. Animal bites are a major cause of preventable traumatic injuries. In order to investigate relationship between regional cerebral blood flow (rCBF) and the white matter lesions on MRI in silent cerebral infarction, we quantitatively measured rCBF by 123I-IMP autoradiography method (IMP ARG method) and single photon emission tomography (SPECT) in 36 patients with silent cerebral infarction (SCI group), 22 patients with multi-infarct dementia (MID group), and 16 control subjects without periventricular hyperintensity (PVH) and lacunar infarction on MRI (CL group).

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Microangiographic observations of the experimentally traumatized spinal cord. Lipid test, a test for placental insufficiency (a preliminary report) Participant observations were carried out during one year at a Burn Unit. These results illustrate a novel mechanism for regulating physiological responses, i.e., ligand-induced stabilization of a constitutively active but inherently unstable protein.

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The number and volume of placental glutathione-S-transferase-positive, glucose-6-phosphatase-negative or ATPase-negative foci were quantified in the liver. Increased perioperative FFP infusion was independently associated with mortality or worse outcomes across a spectrum of surgical risk profiles. The response of insulin to inflammation was slower than corticotropin and the magnitude of the increase was smaller. Impact of smoking cessation on ambulatory blood pressure and heart rate in postmenopausal women.

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Complete resection of the second carotid body tumour was achieved. All the considered outcomes, both in terms of perceived health and wellbeing and health behaviours were associated with participation in formal associations. Therefore we suggested a one-step approach that combines solubilization of inclusion bodies and sulfitolysis of a hybrid protein. Although the MPQ has been adapted into a large number of languages, because of inadequate testing most of the adaptations have unknown clinimetric properties.

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This could be because resistant males are generally smaller, but DDT-R may also alter courtship behaviours. Treatment of a bowenoid papulosis of the penis with local applications of cidofovir in a patient with acquired immunodeficiency syndrome.

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Here we identify Tah11/Sid2, previously isolated through interactions with topoisomerase and Cdk inhibitor mutants, as an ortholog of Cdt1. This observation should initiate investigations into the mechanism of arachidonic acid metabolism and the role of its metabolites in inflammation in the human nervous system. The influence of celebrated Parisian physician Jacques Dubois on the dispensary of Nuremburg Gonadectomy does not significantly alter NA levels in either of the two studied brain areas.