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PTEN is among the most commonly mutated tumor suppressor genes in human cancer. Importantly, bioinformatics analyses of tumor databases support these findings, with methylation of the CREB3L1 gene associated with TNBCs, and strongly negatively correlated with CREB3L1 mRNA expression.

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Response surface methodology appears to be a useful experimental approach for rapid testing of different treatment conditions and determination of optimal values of PDT factors for any PS agent. The study investigated the expression of p53 protein phosphorylated at serine 20 (Ser20) and Ser392 and the association between clinicopathological parameters of ovarian neoplasms with respect to p53 protein overexpression. Effects of two benzodiazepines and a benzodiazepine antagonist on neuromuscular blockade in the anaesthetized cat. Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells--a mechanism of immune evasion?

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Two tuberculides in one patient--a case report of papulonecrotic tuberculide and erythema induratum occurring together. Down-regulation of KAT2B may disrupt the innate and adaptive inflammatory responses due to the suppression of this crucial anti-inflammatory cytokine. The major thrust for clinical application of FOT derives from a number of European clinical research centers. They were also found to be capable of capturing b5R activity from b5R solution and normal human hemolysate. Fall in suicides among mental health patients linked to improvements in mental health services.

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We report a case of transmission of this tumour to a kidney recipient. This review will concentrate on the use of CpG DNA as an adjuvant for the induction of mucosal immunity. Little pitchers use their big ears: preschoolers solve problems by listening to others ask questions.

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All these data may have important implications in our understanding of tumor host interactions and in future strategies of immunotherapy. Physicians treating transplant patients should maintain a high level of awareness towards IFD. On prevalence day, December 31, 1993, 394 subjects (124 men and 270 women) living in the study area were known to suffer from definite and probable MS, giving a crude prevalence rate of 143.9 cases per 100,000 people, 91.6 for males and 195.11 for females.

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Nail acetabular protrusion was observed in 16 cases (3 in early post-operative period, 8 within three months and 2 between the third and the ninth month). Mutants lacking AaAP1 showed increased sensitivity to H(2)O(2) and loss of fungal pathogenicity. Is there any correlation between oocyte polarization microscopy findings with embryo time lapse monitoring in ICSI program? It includes 14 free-living and parasitic species, of which four species belong to endemic Baikal genera - two species from Baicalobdella and one species each from Baicaloclepsis and Codonobdella.

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Cardiovascular factors influencing survival in dialysis patients. Chinese medicinal herbs in the treatment of 61 duodenitis patients Moreover this study favors the possibility to monitor the immunomodulatory mechanisms by non-radioactive in situ hybridization. Modulatory effect of acetylcholine on gonadotropin-stimulated human granulosa cell steroid secretion. Exercise can improve balance and mobility function and reduce the likelihood for falls among community-dwelling older adults with a history of falling.

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Diagnosis and treatment patterns for patients with leptomeningeal metastasis from solid tumors across Europe. The average caloric ingestion in this population is higher than the predicted average waste recommended by WHO, with higher energy values being found in males.

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Extensively porous-coated stems in femoral revision arthroplasty. Importantly, the binding of FGF9(S99N) to its receptor is severely impaired although the dimerization ability of mutant FGF9 itself or with wild-type FGF9 is not detectably affected, providing a basis for the defective FGFR signaling. The goal of this project was to suppress such artifacts with the help of a subtraction procedure.

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Morphology of the nerve cell nucleus in mammals, with special reference to the sex chromatin. The mechanism of reverse isomerization was investigated using stable isotope-labeled retinoids and radioactive tracers to show that this reaction occurs with the retention of configuration of the C-15 carbon of retinol through a mechanism that does not eliminate the hydroxyl group, in contrast to the enzymatic all-trans-retinol to 11-cis-retinol reaction. The correct diagnosis was finally made by bone marrow culture and she responded to a prolonged course of amphotericin B, flucytosine and itraconazole. rhG-CSF crossed the placenta and reached peak fetal serum concentrations 4 hours after administration. Second, input resistance was dominated by the surface area of the apical dendrite.

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The patient had no upward and downward voluntary movements of the eyes since birth, but horizontal movements were normal. Management of wounds of chest and abdomen associated with penetrating brain wounds. Immunohistological analysis of thymoma by molecules differentially expressed in the thymic cortex and medulla, and its application in the differential diagnosis of thymoma from esophageal and lung cancer. In a study of enucleated human eyes, the authors investigated the effect of scleral buckling on the ocular pressure-volume relationship. Methods for critiquing and adapting existent instruments and creating new ones are offered.

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It is postulated that apoptosis contributes to ischemia-reperfusion graft dysfunction after lung transplantation. These results suggest that in the aorta of transgenic rats there is a higher functional tissue renin-angiotensin system that potentiates the vascular reactivity to norepinephrine. This combination is generally safe and well tolerated although, as antipsychotic drug concentrations may be elevated, attention to dose and drug monitoring should be considered appropriately. National Institutes of Health and Agency for Healthcare Research and Quality. The methods proved to be sufficiently successful, enabling participants to perform basic liver surgery like an intraoperative ultrasound investigation, as well as liver dissection techniques, liver suturing, segmental resection and even hepatectomy.

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Most previous research concerning planning of movement has focused on the planning of single, isolated movements. The general clinical outcome in the two groups of patients was similar. Cell to cell transfer of the chromatin-packaged human beta-globin gene cluster.

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Implantation of autologous cells in minced and devitalized rat skeletal muscles. Global warming leads to the concurrence of a number of abiotic and biotic stresses, thus affecting agricultural productivity. The coding capacity of this DNA fragment is supported by the expression of a 26,000 m.w. No significant differences in neuronal population densities were found between the subterritories.

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Our unit has implemented and revised a Golden Hour evidence-based care process that includes the use of realistic videotaped simulations, followed by team debriefing sessions. Changes in nasal responsiveness to histamine and to specific antigen after laser surgery. Selection pressure is exerted by various host defence mechanisms and possible ways of virus transmission. We have seen 9 cases and have reviewed these and the 35 cases reported in Japan between 1919 and 1984.

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An AvaII polymorphism in exon 5 of the human hepatic triglyceride lipase gene. The electron energy limitation (12 MEV at maximum) suggests that the indications for this machine are limited. The ability to detect and identify this organism promptly is important commercially for the quality control of ram semen samples.

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Chondroid tissue in the early facial morphogenesis of the chick embryo. DM has a strong influence on the oral cavity and represents a risk factor for gingivitis and periodontitis. Neglect for low luminance contrast stimuli but not for high colour contrast stimuli: a behavioural and electrophysiological case study. Linkage of a major quantitative trait locus to Yaa gene-induced lupus-like nephritis in (NZW x C57BL/6)F1 mice.

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Histopathological examination of the transvaginal needle biopsy suggested well-differentiated adenocarcinoma. The greatest risk of life-threatening and Cytomegalovirus infections is during the first 6 months post-transplant owing to a high immunosuppressive burden. Kappa, sensitivity and specificity (with confidence intervals) values were calculated for the US and MR angiography results compared to catheter angiography.

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Glucose regulates protein interactions within the yeast SNF1 protein kinase complex. A model of frequency discrimination with optimal processing of auditory nerve spike intervals. Specific fragments reflecting already defined polymorphisms could be identified.

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The Intergenic I region, which lies between the tRNA(gln) and the tRNA(ile) genes, was found to be highly conserved in terms of both size (30 ntp) and nucleotide sequence among the species studied. Bone marrow signal changes occur frequently and are most common in the capitate, lunate and triquetrum. Magnetically induced current densities in aromatic, antiaromatic, homoaromatic, and nonaromatic hydrocarbons.

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Following destruction of the sphenopalatine ganglion there was no discernible change in the density of VIP- and NPY-immunoreactive fibers, while the majority of the NOS-containing fibers disappeared. This prospective randomized study assessed the effects of administering intravenous fluid during bowel preparation. Correspondingly, we find a striking reduction of repressive H3K27me3 in the wound epidermis.

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Acute acalculous cholecystitis is a virulent disease that occurs most commonly in critically ill patients. The finding that membranes expressing rLHR-L435R (a system where internalization does not occur) respond to hCG with an increase in adenylyl cyclase activity supports this suggestion. Recognition errors in the quantification of micro-organisms by fluorescence microscopy. Treatment of chronic cerebrovascular insufficiency: comparison of nimodipine and dihydroergotoxine

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We report a rare case of epithelioid hemangioendothelioma of the urinary bladder. The trial collapsed when the manufacturers stopped making lofexidine on commercial grounds and the charitable foundation which was backing the trial withdrew its support.

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The compartmental model allowed an adequate description of the observed L-dopa and 3-OMD concentrations in the absence and presence of benserazide. As I look forward to the next thirteen years, I feel that this will be an equally exciting period for manipulative genetics as we struggle to formulate concepts and design experiments that enable us to understand gene function in an era when the sequence of all genes will be known. Causes and clinical manifestations of thyrotoxicosis in our patients were comparable with those reported in the literature. The purpose of this study was to assess the effectiveness of free tissue transfer for treatment of advanced mandibular osteoradionecrosis (ORN) in head and neck cancer patients.

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Comparison of FGM with ancient Egyptian male circumcision and consideration of motivations for the practice contribute to our understanding of FGM. Based on these results, we conclude that the LPS-mediated inflammatory environment inhibits BMP-9-induced osteogenic differentiation, via crosstalk between BMP/MAPK and Smad signaling. Bioaccumulation mechanism of red tide alga Prorocentrum micans for heavy metal ions Utilizing reversed-phase HPLC with acetonitrile-water (10:90) at 0.5 ml/min, levels down to 10 microg/l were readily quantified and a detection limit of 4 microg/l was attainable at a signal-to-noise (SIN) ratio of 4. Percutaneous autologus bone marrow grafting in the treatment of ununited fractures and bone defects

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Bone metastases are frequent complications in advanced breast and prostate cancer among others, resulting in increased risk of fractures, pain, hypercalcaemia of malignancy and a reduction in patient independence and mobility. Use of gauze-based negative pressure wound therapy in a pediatric burn patient.

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MR images were evaluated for signs of MCL injury in 76 patients with MCL sprains and 25 asymptomatic volunteers. Depletion of neuronal endoplasmic reticulum calcium stores by thapsigargin: effect on protein synthesis. For HD production, there was no difference between hens on CC and TC or between CC and FC. The use of a screwless implant system and conventional prosthetics, the author contends, can make implant dentistry affordable, versatile and easy to incorporate into all general dental practices.

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Post-transfusion complications and their outcome (according to the data of maternity institutions of Perm from 1957 to 1966) Twenty-two patients admitted over a 2-year period to our department with bilateral hilar adenopathy and a variety of symptoms compatible with sarcoidosis were studied prospectively. Superoleophobic behavior induced by nanofeatures on oleophilic surfaces. Twenty patients with prostatism and a prostatic volume of 30-71 cm3 underwent MR examination before, the day after, and 6 months after treatment.

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A cross-sectional seroepidemiologic survey of chronic hepatitis B virus infections in Southeast Asian immigrants residing in a Canadian urban centre. The effect of daily administration of TGF-beta2 on tissue vasoconstriction, tissue levels of endothelin and angiotensin II, tissue hypoxia, and renal fibrosis were examined.

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The interviewing techniques used on Telemedicine require further evaluation but are exciting and interesting, and can probably teach us a great deal about how we might improve our clinical interviewing style. In contrast, glycine uptake inhibition by alanine and serine was incomplete and neither competitive, non-competitive nor uncompetitive. In a mouse model, we tested whether embryonic exposure to alcohol could exacerbate functional loss as animals age.

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Isolates were homogeneous and belonged to typing group II identified as B. Sera from sensitized rabbits strongly recognized 47 of 100,000 library clones in an antibody-screening assay. The impact of a community driven mass media campaign on the utilisation of maternal health care services in rural Malawi. The differences in SCA1 allele heterogeneity between sperm and blood and within the brain parallels the findings in Huntington disease, suggesting that both disorders share a common mechanism for tissue-specific instability. In experiments where the only control parameter is the heat flow, dissipation is present in terms of an entropy flow from the system to the surroundings.

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MicroRNAs regulate CYP3A4 expression via direct and indirect targeting. To be able to attribute nitroxide mobility to a particular layer of the implant, sandwich-like tablets were manufactured, taking advantage of the distinct spectral features of nitroxides containing different isotopes of nitrogen (15N vs 14N). Although most currently available vasodilators appear to have little direct effect on degenerated elastic arteries, they can act instead on less-degenerated muscular arteries to markedly reduce peripheral wave reflection magnitude and central aortic pressure, and thus contribute to the regression of left ventricular hypertrophy. Additionally, the experimental group patients used unlabeled mouthwash with Triclosan and Gantrez. On the other hand, the putative phi g1e lys product (lysin) of 48.4 kDa shows significant similarity with presumed muramidase, known as a cell wall peptidoglycandegrading enzyme, encoded by the Lactobacillus phage mv1 and phi adh, the Lactococcus lactis phage phi LC3, and the Streptococcus pneumoniae phages Cp-1, Cp-7 and Cp-9.

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In situ hybridization with an antisense cRNA probe revealed that serine dehydratase mRNA was localized in the periportal area of rat liver parenchyma in the evening, whereas it was scarce in the liver in the morning. Our findings indicated the importance of age as a factor modulating hormonal levels and possible clinical manifestations in patients with cortisol-secreting adenomas.

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Well-known cardiotoxic agents are the anthracycline derivatives. We developed a nomogram based on 5 easily available clinical characteristics to predict OS with a high concordance probability. Both patients underwent excision of the tumor because of mechanical interference. The association between hypoglycaemia and myocardial infarction.

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Comparison of zolpidem (Z), triazolam (T), and flunitrazepam (F) effects on arterial blood gases and control of breathing in patients with severe chronic obstructive pulmonary disease (COPD). Collectively, these results demonstrate that CD3-Ti and CD2 pathways are interdependent and that phosphoinositide turnover is linked to the CD3-Ti complex. Interleukin 6 activates heat-shock protein 90 beta gene expression. Radiologically, the irregular end plates of the vertebral bodies, the very small and late appearing epiphyseal ossification centres, and the hypoplastic acetabular roofs are most impressive. Plasma Ang II level also increased after S and D and was significantly greater than placebo at 30 and 45 min after S, and at 30 min and all timepoints thereafter following D.

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T cells from CD28 -/- mice did not bind to epidermal cells derived from normal mice, while cocultivation of T cells with epidermal cells from normal mice demonstrated a significant binding. The finding of a similar reduction at retransplantation in keratoconus suggests reduced corneal extracellular SOD synthesis in cells of the host as a cause of the low enzyme levels.

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In this first pilot study using the measurement of hepatic transit time it was possible to differentiate between patients with and without liver metastases. Early prosthetic valve endocarditis due to Staphylococcus warneri with negative blood culture. We develop a mathematical framework based on the notion of a cut (a particular subset of species in the system), which provides a linear elimination procedure to reduce the number of variables in the system to a set of core variables. In the present study heat capacity profiles and volume changes were obtained. The GTP-bound state of the factor on the ribosome has been studied mainly with non-hydrolyzable analogs of GTP, which led to controversial conclusions about the role of GTP hydrolysis in translocation.

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Metabolic rate of feeding and fasting juvenile midland painted turtles, Chrysemys picta marginata. Strategies for osteoporosis therapy include patient strategies (e.g., administration of calcium, exercise), drug therapy to stimulate bone formation (e.g., fluoride, anabolic steroids), and drugs to inhibit bone resorption (e.g., estrogen replacement therapy, calcitonin, bisphosphonates). After antrotomy it is possible to simulate pathological conditions of the middle ear one after the other at the same temporal bone.

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Ein Beitrag zur Geschichte des Physikats der Stadt Nijmegen im 18. In meningitis without germs, the existence of an inflammatory syndrome leads toward a bacterial etiology while the detection of interferon-alpha (IFN-alpha) in the cerebrospinal fluid (CSF) argues for a viral meningitis. Dynamic surface activity of films of lung surfactant phospholipids, hydrophobic proteins, and neutral lipids. Daily subcutaneous treatment with cyclosporin at the dose of 25 mg/kg per day for fourteen days completely prevented anti-type II collagen antibody production and the serum HA increase as well as development of collagen arthritis. Some orchids use hymenopteran sex pheromones to dupe males into performing pseudocopulation, with extreme species specificity.

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Observations of the changes in standing height at the time of puberty. There were two postoperative deaths, one for myocardial infarction and one for biliary peritonitis. It inhibited VZV growth with EC50 value of 0.038 microg/ml, which is 24-fold stronger than that of acyclovir (0.9 microg/ml).