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Miorel (Baclofen)

Miorel is an oral and injectable medication that relaxes skeletal muscles, the muscles that move the skeleton (and also called striated muscle). Chemically, Miorel is related to gamma-aminobutyric acid (GABA), a naturally occurring neurotransmitter in the brain. Neurotransmitters are chemicals that nerves use to communicate with one another. GABA released by some nerves causes the activity of other nerves to decrease. It is believed that Miorel, acting like GABA, blocks the activity of nerves within the part of the brain that controls the contraction and relaxation of skeletal muscle. Miorel was approved by the FDA in November 1977.

Other names for this medication:
Baclofen, Lioresal, Baclofene, Baclofeno, Baclon, Baclopar, Barambo, Clofen, Kemstro, Liofen, Lyflex, Miorel, Pacifen,

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The microscopic structure of bone in normal children and patients with osteogenesis imperfecta: a survey using backscattered electron imaging. Low concentrations of tetramethylammonium chloride increase yield and specificity of PCR. Among the three class II operons examined, the fliA and fliL operons, but not the flhB operon, could be transcribed by both sigma 70 RNA polymerase holoenzyme with FihD/C (E sigma 70-FlhD/C) and sigma 28 RNA polymerase holoenzyme (E sigma 28). The HMMTOP transmembrane topology prediction server predicts both the localization of helical transmembrane segments and the topology of transmembrane proteins.

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Several encouraging developments towards identifying the neuronal correlate of visual awareness have emerged recently. The staging and treatment of prostate cancer are complex, particularly in patients with clinical disease that has advanced locally beyond the confines of the gland.

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We selected five SNPs in the human APE1/REF-1 gene (rs1760944, rs3136814, rs17111967, rs3136817, and rs1130409), and performed case-control studies in 265 EH patients and 266 age-matched normotensive (NT) subjects. Different forms of the same questionnaire (like self-report or parent report used in paediatric samples) are sometimes compared, usually showing that parent reports supersede the adolescent self-report form.

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Blood gases and pH tend to normalize within 24 hours, whereas gravimetric parameters remain increased. The blink reflex and the corneal reflex are followed by cortical activity resembling the nociceptive potentials induced by trigeminal laser stimulation in man.

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Oxidative and cardiovascular studies on natural and synthetic catecholamines. Effect of catecholamine on the contractile responses of rabbit colon and duodenum to vagus nerve stimulation in vivo. Limited short term effects on number of nuclei after electron irradiation of mouse bladder urothelium. We suggest that this theoretical platform can give us some insights about the nature of shapes in biological systems to understand organizational constraints. Activity and cross-reactivity of antibodies induced in mice by immunization with a group B meningococcal conjugate.

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Another function of erythrocytes: transport of circulating immune complexes. Experimental results show combining the new distributed representation with our HLA-CNN architecture achieves state-of-the-art results in the majority of the latest two Immune Epitope Database (IEDB) weekly automated benchmark datasets. Arrhythmogenic right ventricular cardiomyopathy is a myocardial disease, often familial, clinically characterized by the impending risk of ventricular arrhythmias and sudden death. Crystallographic, theoretical and molecular modelling studies on the conformations of the salicylamide, raclopride, a selective dopamine-D2 antagonist.

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In addition, the histological analysis at the ultrastructural level showed normal glomeruli appearance. We argue that small joint inflammation and damage should be recognized as one aspect of the RA disease process offering unique information and as such should be assessed independently. A case of systemic lupus erythematosus demonstrating basal ganglia calcifications, coronary stenosis and selective IgA deficiency Monoclonal antibodies to human eosinophil plasma membrane antigens enhance the secretion of eosinophil cationic protein. Results of determination of urinary androgens in certain cases of threatened abortion

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By-products containing chlorinated protecting groups caused isotopic patterns characteristic of the natural isotopic distribution of chlorine, were identified on the basis of isotopic distribution. Larger patient cohorts are required for further evaluation of this technique. Levels of yohimbine, its metabolite 11-hydroxy-yohimbine, and clonidine were measured in CSF and plasma samples. The present study has first established and characterized structural properties of a molecular model for polyglutamine diseases in which various lengths of polyglutamine including a pathologically expanded glutamine repeat were inserted into a structurally known protein.

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Chemotherapy led to complete remission, but 21 months later the patient developed an acute myeloid leukemia. These young women will have sexual and reproductive expectations similar to those of their peers and will present to gynecologists for advice and treatment. Regulation by polyamines of ornithine decarboxylase activity and cell division in the unicellular green alga Chlamydomonas reinhardtii. Melatonin also increased self-reported fatigue, confusion, and sleepiness. Activation of the extrinsic coagulation pathway in patients with severe sepsis and septic shock.

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Moreover, a half of them showed high cross-reactivity with influenza viruses of the H7 HA subtype. Mapping human telomere regions with YAC and P1 clones: chromosome-specific markers for 27 telomeres including 149 STSs and 24 polymorphisms for 14 proterminal regions. Moreover, there are no data regarding the mechanisms of volatile anesthetic action on small resistance arteries, which play a critical role in the regulation of blood pressure and blood flow. Topical application of naloxone to the exposed cortex of the anaesthetized gerbil and rat blocked the spc of SD evoked by KCl. The methodology of randomized trials was analyzed and procedures were classed by level of evidence.

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The results indicate that the development of the Friend leukemia does not require the actual presence of CFUE, as seen using Actinomycin D, and is not correlated with the number of pluripotent or granuloid stem cells, as seen after Busulfan. The function of the pedunculopontine nucleus in the preparation and execution of an externally-cued bar pressing task in the rat. In young 12- and 23-day-old rats the correlation between 5-HT in the hypothalamus and corticosterone in the plasma was positive. Treatment of systemic sclerosis patients with r-IFN gamma was relatively safe and well tolerated for doses as high as 150 micrograms m-2 three times weekly. Eyes of patients with either congenital juvenile or angle-closure glaucoma showed COX-2 expression indistinguishable from control eyes.

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The differences between rat strains were already detectable at the beginning of the study. We recently reported development of an experimental model for the study of nitric oxide (NO.) toxicology in vivo. Laparoscopic ultrasonography: the best pretreatment staging modality in gastric adenocarcinoma?

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We found the clock modulator miR-132 and miR-212 to be expressed rhythmically in the central circadian clock. Glucose and xylitol tolerance tests for ketotic and healthy dairy cows.

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Women with gestational diabetes mellitus were treated with low-caloric diet and insulin when appropriate, while women in the control group received routine antenatal care. Amniotic membrane transplantation also has been used in place of conjunctival autografting after pterygium excision and to reconstruct the conjunctival surface after removal of conjunctival lesions. Peripheral blood mononuclear cells (PBMCs) harvested 1 month after the last immunization was compared with pretreatment PBMCs for immunological response.

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The incidence of post-operative complications is much more frequent in patients with neurological deficit than in the other THA patients. As development proceeds, zygotic controls are activated that first limit divisions to defined spatial and temporal domains, coordinating them with morphogenesis, and then halt proliferation altogether, to allow cell differentiation. Functional detection of epithelial cell adhesion molecule specific cytotoxic T lymphocytes in patients with lung cancer, colorectal cancer and in healthy donors. The underlying exposed ducts can then be cannulated while the ensnared ampulla can be retrieved to aid histological diagnosis. Neuropsychological differences between attention deficit hyperactivity disorder and control children and adolescents referred for academic impairment.

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Allelic association of the cystic fibrosis locus and two DNA markers, XV2c and KM19, in 55 German families. Extrapyramidal symptoms following accidental ingestion of risperidone in a child.

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A teaching package of safe intramuscular injection techniques was implemented in October/November 2008. A polar map based on data from 8 normal individuals was used to calculate the extent score (representing the area of decreased uptake) and the severity score (representing the severity of defects) in the patients given ADR. Current experimental studies have demonstrated that peroxynitrite (ONOO-) has both cytotoxic and cytoprotective effects on myocardial ischemia-reperfusion injury. A large-conductance voltage-dependent potassium channel in cultured pig articular chondrocytes. The functional development of the nerve protective barriers was retarded in protein deprived rats.

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The spectrum is similar in many respects to the patients presenting to emergency departments. A Class III furcation invasion in a mandibular molar was treated by surgical access for SRP along with obliterating the furcation utilizing a resin ionomer restoration.

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Critical study of a method of determining amino acids by paper chromatography Despite a preferential action on cerebral vessels, there is clinical and experimental evidence of effects on systemic vascular and intestinal smooth muscle cells. These combined factors contribute to the body of patients who present with low-back, buttock, proximal-thigh, and groin pain.

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Olivomycin was used in 34 out of 66 experiments and 32 experiments were control. Main microorganisms involved in the fermentation of Ugandan ghee. 125I-ICYP binding to intact cells demonstrated a high fraction of non-specific binding, although phentolamine was included in the assay to reduce non-specific binding.

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We found 22 mutations of uneven frequency, including seven novel mutations. Comparison of detection methods of Australia antigen and antibody muscle-centered) reaching plans in motor cortex do not require updating, and so may provide a more stable encoding mechanism. ECoG were recorded from preictal period until 30 min after general tonic clonic convulsion (GTC). In contrast to the results for D-glucose, the sodium-dependent component of alpha-methyl-D-glucoside uptake exhibits a nearly linear Eadie-Hofstee plot consistent with a single carrier site with Km approximately 1.9 mM and Vmax approximately 27 nmol/min per mg protein at pH 7.4, 25 degrees C, 100 mM NaCl gradient.

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The HCMV products US2 and US11 are each sufficient for causing the dislocation of human and murine MHC class I heavy chains from the lumen of the endoplasmic reticulum to the cytosol, where the heavy chains are readily degraded. Ventilating patients in this new mode seem to be safe and well tolerated. Psychiatric comorbidity is common among pathological gamblers and is associated with greater severity of clinical problems.

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At higher stimulus intensities, orthodromic and antidromic population spike amplitudes were not increased at 5 MPa but were significantly enhanced at 10 MPa, and multiple population spikes were observed in some experiments. Although both prazosin and arginine prevented the cold-induced elevation of blood pressure, they did not prevent the increase in TH mRNA, TH activity or epinephrine in plasma. When BN210, KP3 and KP9 were simultaneously inoculated in a membrane reactor supplied with 3-chlorobenzoate, strain KP3 outcompeted the two other strains and remained the major 3-chlorobenzoate degrading population in the reactor. The underlying mechanisms in the development of diabetic nephropathy are currently unclear and likely consist of a series of dynamic events from the early to late stages of the disease. Parathyroid surgery and methylene blue: a review with guidelines for safe intraoperative use.

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Effect of a local cold-induced lesion of the skin on the activity of hydrolases and their inhibitors in the blood serum of rabbits Religious institutes must consider the direction in which they will go.

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We then confirmed that LPS and BMP-9 can activate p38MAPK and ERK1/2 signaling, and that LPS stimulation reduces BMP-9-induced Runx2 expression through the activation of p38MAPK and ERK1/2 signaling. A report on lesions diagnosed in the school of dentistry biopsy service, University of Oregon Health Sciences Center-1976-77. Exercise training is known to increase cardiovascular performance, and there is some evidence of a cross-adaptation between exercise and cold tolerance in young rats. Here we use in situ hybridization and digital imaging microscopy to examine the intranuclear distributions of intron-containing HIV RNAs and to determine their spatial relationships to intranuclear structures.

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Ectodermal abnormalities such as hair abnormality and hirsutism are symptoms of Kabuki syndrome, and pilomatricomas are frequently associated with the mutations of beta-catenin in hair follicle development. Urgent computed tomography (CT) scan revealed a giant bilobed aortic sac, corresponding with a huge hygroma. Type 1 patients with male transmission showed worse anticipations than type 1 patients with female transmission. On repeated daily dosing in dogs for two weeks, no tolerance was developed to the pharmacological action.

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Last, the characteristics of animal models that have been developed for the study of the potential role of viruses in the initiation and progression of autoimmune disease are reviewed. The concentration of 5-methoxypsoralen in the skin was similar in both psoriatic and healthy sites, indicating that the pathology does not influence drug distribution in the skin. Elimination of carbendazim from fruit conditioning waters by adsorption on different materials Normal blood basophils express only trace amounts of the enzyme. The results show that acute hyperglycemia has an important impact on small-intestinal motility.

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Sexual maturational changes circulatory inhibin concentration in relation to FSH concentration and testicular size in Suffolk and DLS rams. Yeast Saccharomyces cerevisiae MTO2, MTO1, and MSS1 genes encoded highly conserved tRNA modifying enzymes for the biosynthesis of carboxymethylaminomethyl (cmnm)(5)s(2)U(34) in mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln). However, possible vasodilatory properties of propranolol at higher concentrations may counteract splanchnic vasoconstriction. Defective maturation and function of antigen-presenting cells in type 1 diabetes. Need for a paradigm shift: the importance of risk factor reduction therapy in treating patients with cardiovascular disease.

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avium with the smooth colony type were pathogenic in turkeys but not in chickens. Palladium-catalyzed synthesis of 2,3-dihydro-2-ylidene-1,4-benzodioxins. A series of 13 patients with an excentered osteoarthritis of the glenoid who underwent bipolar shoulder arthroplasty is reported. In rat pups, repeated, brief (i.e., 15 min) maternal separation (MS15) during the first 1-2 postnatal weeks has been shown to increase active maternal care and to reduce later anxiety-like behavior in the offspring. to the DNA group level by phenotypic techniques is problematic, and there is a need for an alternative identification method for routine use.

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We evaluated a metronidazole-resistant and a clarithromycin-resistant strain of H. The hygienic aspect of the sensor lies in the applied temperature (37 degrees C) and the use of N2 as decarbonizing gas, thus creating conditions favorable for enteric bacteria. A 64-yr-old man with Crigler-Najjar syndrome type II underwent cholecystectomy.

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Higher concentrations (100 microM and 1 mM) evoked relaxation which was often though not invariably accompanied by transient hyperpolarization and transient inhibition of electrical slow waves in the impaled cell. Management options include simple aspiration with sclerotherapy and operative marsupialization of the lymphoceles into the peritoneal cavity. THP-1 monocytes and human monocytes with and without platelets were cultured with hyphae from A. Intralymphatic interleukin-2 in combination with zidovudine for the therapy of patients with AIDS. Specifically, patients with high levels of pGDF15 had lower probabilities of event-free and overall survival 30 months after diagnosis than patients with low pGDF15 levels.

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We report a case of pulmonary hemoptysis induced by a balloon-tipped catheter. These immature DCs can take up invading pathogens and then rapidly migrate to the draining secondary lymphoid organs. This method of immobilization should be widely applicable to many soluble protein molecules, to which an anchor can be attached by routine methods of molecular engineering. After three years, a pleural seroma, a cutaneous mass and testicular nodule were observed and cytological examination showed endothelial cells. In contrast, pretreatment with U-50,488H (a single dose of 1 mg/kg i.p.) rendered tolerant the rats to U-50,488H, but the animals did not develop cross-tolerance to morphine.

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Objective of this study is to make comparison between the treatment effects on functional and nonfunctional CBTs. Microscopic examination revealed that the tumor mass had characteristic features of a teratoma and was composed of several types of differentiated cells and tissues at various stages of maturation. Problem solving in relation to resources in everyday life in families of children with disabilities: a pilot study. Are there evidence-based indications for an arthroscopic Bankart repair. Water magnetic relaxation dispersion in biological systems: the contribution of proton exchange and implications for the noninvasive detection of cartilage degradation.

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However, in cells in which IGF2 imprinting was lost (LOI), nearly all of the long-range chromatin interactions involving IGF2 were abrogated. At 4 weeks, allografted skin was replaced by granulation tissue, which mediated the adhesion of the grafts to the underlying tissue. These results emphasize the role of flanking residues on the lack of processing of cryptic determinants and the importance of the life span of peptide-MHC complexes to stimulate T cell responses. This article reports the results of resting and reading studies performed in a simulator that represents the interior of acyclovir dosage for herpes simplex keratitis symptoms a commercial aircraft. Assessment of hip and knee joint activity using an angular displacement activity monitor.

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In an effort to determine which of the peptidase activities needs to be inhibited for neurite outgrowth to occur, we treated Neuro 2A cells with peptide bactrim 80 400 dosage of aspirin aldehydes that selectively inhibit different proteasome activities. Results of radiotherapy for drooling in amyotrophic lateral sclerosis. The Lyme disease spirochete, Borrelia burgdorferi, produces a number of surface proteins that bind to factor H related molecules, which function as the dominant negative regulator of the alternative pathway of complement. Methodological problems associated with the use of protein pattern analysis in cells with altered chromosome sets for the purposes of genetic mapping are discussed.

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Intravenous injection of small interfering RNA targeting FAK was used to silence expression of the kinase in pulmonary tissue. ABA also induces the accumulation of the basic leucine zipper (bZIP) transcription factor ABA-insensitive 5 (ABI5) which, apart from blocking endosperm rupture, also protects the embryo by stimulating the expression of late embryogenesis abundant (LEA) genes that conferred osmotolerance during seed maturation. This claire xl clarithromycin dosage procedure has been performed safely in more than 30 patients without significant morbidity. A theoretical and numerical study of the acoustic field intensity within a curved flow conduit having 1) diameter similar to the wavelength of the interrogating frequency and 2) speed of sound mismatch with the surrounding medium is presented. Their relationship with the broader group of mantle cell and mucosa-associated lymphoid tissue (MALT) lymphomas is also discussed.

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A recombinant single-chain variable fragment (scFv) antibody was engineered to a tissue-specific carbohydrate epitope located mahacef oz tablet uses on human sperm agglutination antigen-1 (SAGA-1), a sperm glycoform of CD52. These correspond to two submetacentric-subtelocentric pairs, as was previously reported in M.

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Deciphering whether a transient neurological pfizer remoxy 2013 nfl event (TNE) is of ischemic or nonischemic etiology can be challenging. Pharmacokinetic and clinical profile of a novel formulation of bosentan in children with pulmonary arterial hypertension: the FUTURE-1 study. Shared clinical rotations, between an established 5-year and a new graduate entry course, provide the opportunity to compare achievement on clinical assessments. The main issue regarding the approach to the patient with uninvestigated dyspepsia is whether the symptoms are the result of an important clinical illness, which then determines the appropriate management strategy for the treatment of the symptoms. The effect of zanamivir treatment on the early immune response to influenza vaccination.

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Bone scintigraphy for osteonecrosis of the knee in patients with non-traumatic osteonecrosis of the femoral head: comparison with magnetic resonance imaging. These two transitions correspond to the polymorphic transition of anhydrous cholesterol and antibiotic spectrum of clindamycin gel to the dehydration of cholesterol monohydrate, respectively.

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Coffee consumption and other baseline variables of 2606 middle-aged Finnish twins were assessed in 1975 and 1981 by postal questionnaires. Severe hypoxia leads to a cessation of cell growth and causes an accumulation of cells in G1. As SP has been implicated in the pathogenesis of inflammatory cutaneous lesions, we hascovir 200 mg ulotka wondered whether SPR localization was modified in psoriatic lesions.

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Ischaemic heart diseases remain, with idiopathic cardiomyopathies, the main indications for cardiac transplant. In each patient, total and permanent relief ticagrelor vs clopidogrel pdf995 of pain was achieved.

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Cocaine use and characteristics of young adult users generic name of drug augmentin from 1987 to 1992: the CARDIA Study. A number of recent studies of long-term kidney donors have reviewed glomerular function and blood pressure.

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Changes of HRQoL during adjuvant therapy may be associated with recurrence. Sixty percent of family physicians and 56 percent of obstetrician-gynecologists were more willing to provide prenatal care to Medicaid patients as a result of the expansion. There was no positive history for both the congenital and the acquired type of lesion. Due to the structural similarity between the component acyl pyruvate weight immunophilins, FKBP52 and cyclophilin 40, we decided to investigate whether CyP40 is also a heat shock protein. We believe this is the first case report of a mesenchymoma causing sudden death due to massive tumor embolism.

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We assess the feasibility of evaluating acute stress disorder (ASD) symptoms in the emergency department and provide an initial estimate of the prevalence, severity, and variability of these symptoms in violently injured urban children and young adults. However, many current classification systems lack good reliability, both inter-observer and intra-observer for different image types. Three-dimensional (3-D) morphology of neurons of the terminal nerve plexus flagyl 500 mg comprimidos trazodona of the atrioventricular junction was examined in a scanning electron microscope. These include (1) the long and probably variable latent periods between causative events and cancer diagnosis, (2) the limited numbers of cases available for study in any given cluster situation, and (3) the clinical non-specificity of cancer cases whereby no readily available means are at hand to identify the specific causes for any particular case. It was our goal to compare the efficacy of a suburethral fascial sling with that of a combination of Marshall-Marchetti-Krantz urethropexy and Ball urethroplasty in patients with intrinsic sphincter deficiency and urethral hypermobility.