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The analysis of the single-channel data using the Renkin correction factor suggested that the EHEC-hemolysin formed channels with an average diameter of 2.6 nm. Furthermore, the ever-increasing threat of emerging infections is taxing our surveillance and detection procedures. These preliminary data suggest that, in addition to walking performance, muscle strength can be increased in PAD patients after 4 wk of supplementation with propionyl-L-carnitine. Lymphoid hyperplasia of lower rectum mimics a polypoid type of malignant lymphoma.

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The increase in capillary permeability was abrogated by pretreatment of mice with anti-CF antibodies, avil (H1 receptor blocker) or ranitidine (H2 receptor blocker). Do delayed prescriptions reduce the use of antibiotics for the common cold? Membranes were subjected to a cytocompatibility test in which the attachment and morphology of primary hepatocytes were evaluated. Twelve women with prospectively confirmed premenstrual dysphoric disorder (PMDD or PDD) were compared with 12 healthy control subjects for cardiovascular and neuroendocrine responses to speech and mental arithmetic (Paced Auditory Serial Addition Task) stressors during both the follicular and luteal phases of the menstrual cycle.

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Many human sera contain natural antibodies directed against the fetal antigens appearing in vitro. The aim of this paper is to summarize the basis behind PARP inhibitors and update the current status of their development in clinical trials for the treatment of TNBC.

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The design can be constructed according to user-oriented specifications by selecting adequate components from corresponding libraries, with the help of a genetic algorithm (GA)-based design method. Perfusion of HCl into any segment did not affect plasma levels of PP. RF catheter ablation can be performed successfully from the VT exit site or the zone of slow conduction where the Purkinje potential was recorded in the diastolic phase. We present new comparative evidence on heart attack care in seventeen countries showing that technological change--changes in medical treatments that affect the quality and cost of care--is universal but has differed greatly around the world. Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta.

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Phylogeography and population dynamics of dengue viruses in the Americas. In families with hereditary forms of cancer, the use of genetic tests to determine whether family members have inherited susceptibility mutations (ISMs) may improve outcome. Reduced functional expression and molecular synthesis of inducible nitric oxide synthase in rostral ventrolateral medulla of spontaneously hypertensive rats. In this study, CD-1 mice were infected percutaneously with 1600 cercariae of Schistosoma mansoni and their pain sensitivity and exploratory behavior were analyzed in well-standardized tests (hot-plate, hole-board, open-field, novel object investigation and black/white box). F-actin was stained with fluorescein-isothiocyanate phalloidin and fluorescence measurements were performed by confocal microscopy.

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Activation of recombinant human prothrombin and recombinant D419N-prothrombin by snake venoms from Echis carinatus and Oxyuranus scutellatus. Because UDP formed after glucosyl transfer can be directly recycled with sucrose synthase, UDP-glucose formed appears to show high turnover with cellulose synthase in the coupled reaction.

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Small-scale structure of the geodynamo inferred from Oersted and Magsat satellite data. Here we report that the fast desensitization of NR1/NR2A receptors is caused by ambient zinc, and that a positive allosteric interaction occurs between the extracellular zinc-binding site located in the amino terminal domain and the glutamate-binding domain of NR2A. The accuracy of estimating additive variance components and breeding values improved as more pedigree information and historical data were included in analyses.

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Liver biopsies from 15 early (stages I and II) and 14 late (stages III and IV) cases of PBC and 15 normal cases were examined immunohistochemically for expression of p53, CD95/Fas, bax, bcl-x, bcl-2 and the proliferation marker Ki-67. CFI was found to markedly inhibit the neutrophil chemotactic activity of partially purified C5a containing GcG (p less than 0.01). Analytical criteria such as recovery rates, repeatability, reproducibility and robustness are evaluated through a broad range of biological matrices and reference materials analysis. Echocardiography revealed a right atrial tumor with right to left shunt through PFO. In the absence of Mss2p, the Cox2p N terminus is exported, but Cox2p C-terminal export and assembly of Cox2p into cytochrome oxidase is blocked.

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We therefore prospectively evaluated forty unselected consecutive female SLE patients for evidence of audiovestibular dysfunction and compared the results with those of 65 age-matched healthy women. Low molecular weight heparins are administered subcutaneously and require minimal laboratory monitoring and dose adjustment, offering important benefits to children with poor venous access. Cryoballoon pulmonary vein isolation with real-time recordings from the pulmonary veins.

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PubMed, EMBASE, Cumulative Index to Nursing and Allied Health Literature, the Cochrane Database of Systematic Reviews and PsychInfo were searched for studies published between January 1990 and July 2014. In this review, new inhibitors of entry and fusion are summarized that are promising. Haplotypes were constructed with microsatellites flanking the locus, and TGM1 genotypes of the family were used to determine parental origins of the mutations.

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Aberrant caveolin-1-mediated Smad signaling and proliferation identified by analysis of adenine 474 deletion mutation (c.474delA) in patient fibroblasts: a new perspective on the mechanism of pulmonary hypertension. Structural chromosome aberrations in the peripheral blood lymphocytes in patients with precancer and endometrial cancer

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Proceedings of a Consensus Conference Held by the Royal College of Physicians of Edinburgh, May 9-10, 1994. The purpose of this paper is to indicate the possibility of shunt removal using the programmable Medos and Sophy valves (one programmable Sophy valve was specially designed for this situation). Peter Klara express opposing views on the need for fusion after discectomy and support their perspectives with clinical experience and a review of the pathoanatomy of disc disease. The syntenic relationship of these genes is conserved on human chromosome 2q and also on mouse chromosome 1.

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The clinical features of Moyamoya disease were retrospectively analyzed. In addition, the patient subsequently developed clear cell carcinoma of the endometrium, possibly related to radiation therapy for the prostatic adenocarcinoma.

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When the 134 kDa protein was heated to 100 degrees C for 10 min in sample buffer, it dissociated into subunits with a molecular mass of about 23 kDa and focused at pI of 4.5 during isoelectric focusing. Acute necrotising pancreatitis was induced by intraperitoneal caerulein. Microvascular features of normal rat livers and bile duct system were examined with the vascular casts using methacrylated resin. Each year, poison control centers (PCCs) receive more than 25,000 calls related to workplace exposures to hazardous substances. Evaluation of diffuse pulmonary hemorrhage with conventional radiologic methods

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Analysis of pyogenic microflora structure of a cardiac surgery hospital Since 2006, 71 TOGA procedures were performed in morbidly obese patients.

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Further, the actual risk of surgeon-to-patient transmission appears to be extremely small. Patients who had early resolution of atelectasis had already been on anti-inflammatory medications, and responded better to aggressive treatment within the first week. The present modifications allow uncomplicated and rapid recognition of red tumour fluorescence and its borders to normal tissue, without interrupting the course of the operation. Southern analysis of the cloned human gene suggests a wide distribution of the gene family in various species. Whilst in contrast with some autoimmune disorders a clear association between human leukocyte antigen (HLA) and sarcoidosis is still a controversial issue, there is, however, a general agreement that some HLA genes are related to phenotypic variations of the disease.

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Our findings lead to the conclusion that the currently used hydrophobicity scales, based on partition coefficients between water and an organic solvent, are inadequate measures of the contribution of side chains being transferred from water to the interior of the protein. More restricted expression of t-PDF suggests that activation of PDFR accelerates cellular timekeeping in some clock neurons while decelerating others. Eleven patients had osteomyelitis with no bone abscess and six had osteomyelitis with a subacute or chronic bone abscess. Genetic analysis of 17 Y-STR loci in Han and Korean populations from Jilin Province, Northeast China. Statistical total correlation spectroscopy editing of 1H NMR spectra of biofluids: application to drug metabolite profile identification and enhanced information recovery.

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In this study we examined whether the growth nonpermissiveness of fish optic nerves which had not been injured prior to their excision results, at least in part, from the presence of myelin-associated growth inhibitors. Impacts of Rho kinase inhibitor Fasudil on Rho/ROCK signaling pathway in rabbits with optic nerve injury. Natural history of obstructive coronary artery disease: ten-year study of 601 nonsurgical cases.

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Relationship of serum ACE inhibition to oral dose of enalapril in normotensive volunteers. Hamster to rat kidney transplantation: technique, functional outcome and complications.

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A simple and sensitive extraction-gravimetric method for the determination of dipyridamole is presented. The phorbol ester, phorbol 12-myristate 13-acetate (PMA), the calcium ionophores A23187, the chemotactic peptide fMLP and lipopolysaccharide(LPS) were introduced in these experiments as stimulators.

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Potentially inappropriate prescribing in two populations with differing socio-economic profiles: a cross-sectional database study using the PROMPT criteria. Rather awkwardly for the Prion hypothesis, PrP0/0 knockout mice have been found to incubate and transmit TSE agents (despite themselves being refractory to TSE disease). Using creative methods in qualitative research promotes participation. The measurement of enzyme activities in the resting human polymorphonuclear leukocyte--critical estimate of a method.

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We report the first case of CHIKV infection with chronic associated rheumatism in a patient who developed progressive erosive arthritis with expression of inflammatory mediators and persistence of specific IgM antibodies over 24 months following infection. Effects of the beta-2 adrenergic agonist zinterol on DRL behavior and locomotor activity. A sensitivity of CRP determination of cord blood and neonatal serum for neonatal infection

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Matrix solid-phase dispersion technique for the determination of moxidectin in bovine tissues. Advantages of strict (Tygerberg) criteria for evaluation of sperm morphology.

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Stable-isotope-based labeling of styrene-degrading microorganisms in biofilters. D-cycloserine, a partial NMDA receptor-associated glycine-B site agonist, enhances reversal learning, but a cholinesterase inhibitor and nicotine has no effect. Vasodilation of epicardial coronary arteries in response to nitroglycerin and increases in flow velocity in response to papaverine were similar in both groups. No changes in the blood taurine levels were observed in the animals administered a L-cysteine test-load.

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In this study, we gained a total of 25,981 and 5,775 high quality SNPs in two transcriptomes from individuals and cell lines, respectively. Comparing perceptions of the social determinants of health between non-profit and governmental actors in two Canadian cities. Presence of UTI as defined as bacteriuria with a colony count of at least 10(5) colony-forming units/mL and at least 1 sign or symptom of UTI.

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Reappraisal of internal mammary lymph node dissection in selected patients with invasive breast cancer. The analysis of cell fractionation showed that the APX protein is distributed in the cytosol, but not the plastids, suggesting that Euglena APX becomes mature in the cytosol after processing of the precursor. In these cases, the beta protein appeared to be translocated into the nucleus passively by binding to alpha A1.

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Alteration in rat liver microsomal membranes induced by acetaminophen. Gene socialization: gene order, GC content and gene silencing in Salmonella.

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The recovery of Farage cells which had been exposed to IL-4 for six days was not complete and eleven days after withdrawal of the cytokine, these cells still displayed a lower level of CD21 and of CD38 than control cells. Contribution of infectious disease consultation toward the care of inpatients being considered for community-based parenteral anti-infective therapy.

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This study demonstrates the efficacy of this hyaluronan-based scaffold for autologous chondrocytes transplantation. A prospective, consecutive cohort analysis of the regression of the incidence and intensity of back and posterior pelvic pain after delivery in pregnant women was done. Direct interaction with contactin targets voltage-gated sodium channel Na(v)1.9/NaN to the cell membrane. Our results suggest that PIR is required for terminal myeloid maturation, and its downregulation may contribute to the differentiation arrest associated with AML. Differential expression of progression-related genes in the evolution of superficial to invasive transitional cell carcinoma of the bladder.

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Alpha adrenoceptor regulation of coronary artery blood flow in normal and stenotic canine coronary arteries. In a retrospective study, the perioperative and late complications were recorded in this homogeneous patient group.

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Structural determinants for specific recognition by T4 endonuclease V. The spatial hot/cold spots and its trend, and the time frame and areas of its spatial-temporal clustering of hepatitis B in Gansu were analyzed by using the county specific incidence of hepatitis B from 2009 to 2014 and spatial statistical software GeoDa and SatScan.

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They are also evolutionarily highly divergent organisms, and the many unique aspects of trypanosome biology provide opportunities in terms of identification of drug targets, the challenge of exploiting these putative targets and, at the same time, significant scope for exploration of novel and divergent cell biology. Des(1-3)IGF-I, a truncated variant of human IGF-I with the tripeptide Gly-Pro-Glu absent from the N-terminus, has been isolated from bovine colostrum, human brain and porcine uterus. Acid-base balance in hypotrophic neonates in the first hours of life