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The hypolipidemic fibric acid drugs are peroxisome proliferator-activated receptor a (PPAR alpha) ligands. We tested the utility of a highly sensitive proteomics-based functional diagnostic platform, Collaborative Enzyme Enhanced Reactive-immunoassay (CEERTM), on fine-needle aspiration (FNA) samples obtained from 102 patients with radiographically-evident pancreatic tumors. We attempted to determine whether the results of transrectal ultrasonography (TRUS) could provide any prognostic information about patients with rectal carcinoma treated with pre-operative radiotherapy (RT). This lesion is located in the same region as several previously described inactivating mutations of glucocorticoid receptors, suggesting that the structure/function relationship of the virally transduced form of the c-erbA/thyroid hormone receptor is closely similar to that of steroid hormone receptors. Electronic and steric control in regioselective addition reactions of organolithium reagents with enaldimines.

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Hypothalamic sites of progestin action on aggression and sexual behavior in female Syrian hamsters. The TnphoA-induced Bradyrhizobium japonicum mutant 184 shows slow growth and aberrant colonization of soybean nodules.

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Vasomotor and permeability effects of bradykinin in the cerebral microcirculation. In vivo trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors. Northern blot analysis showed that concentrations of corresponding mRNAs of hDRS and hDRS delta 32 were greatly enhanced in transfected cells. It is suggested that HCV could replicate more efficiently in noncancerous than in cancerous tissues.

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We conclude that IL-9 is a stimulus for airway epithelial cell release of T-cell chemoattractant factors, which in turn may modulate the immune response in allergic airway inflammation. 111In-octreotide scintigraphy in metastatic medullary thyroid carcinoma before and after octreotide therapy: in vivo evidence of the possible down-regulation of somatostatin receptors. A worldwide trend towards increasing life expectancy has meant that osteoporosis is emerging as an important public health problem. There are nearly 400 modern domestic dog breeds with a unique histories and genetic profiles. Macrophage cultures from estriol treated animals however, did not demonstrate significant differences from the placebo group for TNF or NO secretion following in vitro LPS challenge.

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The kinetics of binding differed between the sexes, estradiol being retained less well in males. Molecular cloning and sequencing of cDNA encoding goat pre alpha-lactalbumin.

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Additionally, we reveal that denticle placodes possess columnar epithelial cells with a reduced rate of proliferation, a conserved characteristic of amniote skin appendage development. Until a large-scale clinical trial of newborn jaundice management is performed, a variety of practices should continue to be acceptable. Two of the strains were chloroquine sensitive and one was partially chloroquine resistant.

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Delayed SIPS occurs in melanocytes from light-skinned populations since a reduced association of p16(Ink-4a) with CDK4 and reduced phosphorylation of the retinoblastoma protein are observed. Further research into many aspects of the biology of these organisms is urgently needed. Behavioral measures were determined prior to and immediately after tDCS. Serum cholesterol and cancer in the NHANES I epidemiologic followup study.

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The middle-ear transfer characteristics for sound in 14 human temporal bones were determined using a SQUID magnetometer method. However, in contrast to the excellent surgical care provided to these patients in the Western hemisphere and despite good medical options, causative treatment of the underlying osteopathy causing skeletal fragility remains an unmet medical need that urgently needs to be improved. Because of the initial impairment of the inhibitory interneurons by ischaemia and hypoxia, the amplitude of SEP might increase transiently.

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Theanine as a glutamate antagonist at a crayfish neuromuscular junction. Treatment of fibroblasts with the phorbol ester, 12-O-tetradecanoyl phorbol 13-acetate (TPA), specifically inhibits fibroblast growth factor-2 (FGF-2) induced proliferation. The effect of microsphere production parameters upon these release profiles has been investigated. These changes in the cross-link profile of the intervertebral disc in degenerative disc disease and scoliosis are indicative of increased matrix turnover and tissue remodeling and likely to have implications for the progression of these disorders. The advantage of using minimally invasive techniques over open techniques in the repair of groin hernias is still debated.

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Vaccine efficacy and immune response to swine influenza virus challenge in pigs infected with porcine reproductive and respiratory syndrome virus at the time of SIV vaccination. Specific treatment of varicocele-associated male factor infertility with surgical varicocelectomy is more cost-effective than primary treatment with assisted reproduction.

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Using VA administrative data, bivariate and multivariate statistics were used to examine gender differences in health service use among 159,705 Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) veterans with PTSD seeking VA healthcare from October 7, 2001, to December 31, 2010. No significant difference was found for both receptors between the locations in the outer root sheath, among the three different hair types, between sex and between intact and castrated dogs. Preventive ischemia in the surgery of complicated renal lithiasis

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These results show that factors secreted from damaged white matter inhibit axonal regeneration and that the majority of inhibitory activity can be accounted for by dMAG. The staff satisfaction survey also included a demographic data sheet. Regions of interest included CSF spaces, lobar regions, and limbic-subcortical regions. In the absence of this cytokine, cells revert to an epithelial phenotype in 3-4 weeks and recover the response to TGF-beta.

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An unexpectedly high excision capacity for mispaired 5-hydroxymethyluracil in human cell extracts. burgdorferi clones derived from a mouse that was infected with B31-5A3 capillary-fed nymphs showed considerable recombination.

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We compared the effects of these agents administered in vivo on GPIb-mediated platelet adhesion to von Willebrand factor (vWF)/collagen type I (as in atherosclerotic subendothelium) and on subsequent GPIIb-IIIa-fibrinogen/vWF-mediated platelet aggregation under flowing conditions analogous to those in constricted coronary arteries. Dynamic spiral MRI of pulmonary gas flow using hyperpolarized (3)He: preliminary studies in healthy and diseased lungs.

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Antisense inhibition of gephyrin expression prevents GlyR accumulation at postsynaptic membrane specialization. Intracellular studies of heterosynaptic long-term depression (LTD) in CA1 of hippocampal slices.

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We also compare R2 statistics and use simulated health plans to evaluate the performance of alternative models. Addition of cyproterone and oestrogen supplements had no effect and significant virilization persisted. A population-based study of referral, diagnostic and treatment patterns for childhood acute lymphocytic leukemia. IVC filters were successfully placed at the suprarenal position. Although the mechanisms implicated in the pathogenesis of secondary mania have not been established, this case adds to the growing evidence that head injury may be directly causative in affective psychoses.

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Diagnosis of subarachnoid haemorrhage (SAH) is firstly based on imaging and secondly on spectrophotometry. Recently, topical steroid application has been shown by a small number of studies to be an effective alternative to circumcision for the treatment of phimosis.

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Jugular venous and arterial concentrations of serum S-100B protein in patients with severe head injury: a pilot study. 38:1-10, 1993) indicates the possibility that CPV and FPLV undergo mutual interspecies transmission between dogs and cats, and it is postulated that they may cause disease in some adventitious hosts. This study was performed to validate a new staging system and support the concept of early regional lymphadenectomy based on this system. Among these are members of the Src family of tyrosine kinases, the phosphatidylinositol 3-kinase, the serine/threonine phosphatase PP2A and the adaptor protein Shc (in the case of MomT).

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Fetal breathing was significantly reduced in the two fetuses which subsequently died and in five of six fetuses developing fetal distress in labour. Immunohistochemically, the tumor cells expressed MyoD1 (10/10), Desmin (10/10), myogenin (6/10), AE1/AE3 (2/10), EMA (2/10), but were negative for SMA, caldesmon, S-100.

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NIR spectra of one hundred and eighty tablets from three feasibility batches were used as the pseudo-calibration set. Spontaneous resolution of soft-tissue interposition after closed reduction of hip endoprosthesis dislocation. A twelve-week independent and double-blind clinical study was conducted on a sample of 143 calculus forming adult male and female subjects--with the average age of 39.11 years--to compare directly the anticalculus efficacy of three commercially-available dentifrices, as compared to a placebo dentifrice. Biochemical and functional study of the liver during treatment of familial hyperlipoproteinemia with Mevacor (lovastatin) and Vasosan S (cholestyramine) An outline and bibliography for a seminar in clinical psychology for resident physicians in psychiatry.

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Tuberculous infection and its source in primary school children. The objective of this study was to determine whether a sequential therapy regimen is effective in eradicating H. The described method allows designing practical TMS coils that have considerably higher efficiency than conventional figure-of-eight coils.

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Cell-derived apolipoprotein E (ApoE) particles inhibit vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells. We give some mathematical results about convergence of this process. The serum AFP level returned to normal after 2 courses of the new regimen, and no tumor was visible on the follow-up magnetic resonance imaging study. Enhanced understanding of the molecular mechanics of AMPK activation might lead to novel therapeutic approaches. We quantified the degree to which different toxicity priorities might be incorporated into treatment plan selection, to elucidate the feasible decision space for shared decision making in anal cancer radiotherapy.

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Effect of individual-adaptive psychophysiological correction on operator working capacity We report here an analysis of the expression and function of the alpha chain of human VLA-4 in stable mouse L cell transfectants and the requirement for the beta chain in these processes. Preoperative patient-oriented advance planning of emergency and intensive care treatment--Necessary or imposition? These data suggest that transrepression of NF-kappaB and AP-1 occurs through distinct protein-protein interactions and argue against the hypothesis that transrepression occurs through competition for a single coactivator protein.

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The only difference in response between male and female rats was the more pronounced fall in colonic temperature observed in morphine-dependent female rats following administration of naloxone. Fully aware that over the past 50 years at least eight major national commissions in the USA alone have made similar claims, the present reality is such that the pressure for change has greater force than at any time since the beginning of the century, when the overall form of modern medical education was set. The influence was linear but there was interaction with recipient age. Diverticulitis: the relationship between body mass index and disease location, recurrence, and complications. There is an age-associated increase in the prevalence of dyslipidaemia as well as diabetes.

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Human event-related potentials and distraction during selective listening. A review of 806 caesarean operations performed at the Queen Victoria Maternity Hospital, Adelaide, in the years 1965-1969. The incidence of hip fracture among Japanese in Hawaii between 1991-1995 had not changed appreciably (compared to 1979-1981), and was similar to that among Caucasians on Oahu. Only a small change in the length of the induction period that results from the fibrinogen-fibrin monomer interactions was observed.

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Contrary to the predominant deficit theories, a fresh asset-oriented approach is provided. Patient-related factors and dosimetric values were examined in Cox regression analyses for bRFS and late toxicity. Effects of Morus root bark extract and active constituents on blood lipids in hyperlipidemia rats. In each experiment, pattern identification was assessed by asking observers to judge whether a near-threshold test pattern was the same or different in shape to a high-contrast comparison pattern. These results demonstrate the key importance of Gpx5 as an extracellular antioxidant designed to protect maturing mammalian spermatozoa from oxidative stress.

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Perceived support among Iranian mothers of children with learning disability. Results may reflect the inability of the chondrocyte of the developing joint to alter matrix components that would allow proper maturation and differentiation into bone. Despite its recent growing popularity for treating VSP, our experience suggests that residual shunt is an important issue remains to be solved in David method.

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Acute phencyclidine neurotoxicity in rat forebrain: induction of haem oxygenase-1 and attenuation by the antioxidant dimethylthiourea. Since this might be expected to affect sarcoidosis, an investigation of 108 sarcoidosis patients and 113 healthy control subjects was performed.

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A group of 37 patients with histologically verified SBCCs were included. Primary choriocarcinoma arising in the placenta during a seemingly normal gestation is rare.

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Ectopic expression of the MCC gene by microinjection in normal NIH3T3 cell lines leads to inhibition of DNA synthesis. Compounds which have a small methyl group substituted at the alpha-methylene group showed weaker activity than compounds with a larger carbethoxyalkyl substituent, indicating that the lipophilicity and the steric effect of the molecules play important roles in their antimalarial activity. Histopathological examination showed radionecrosis of the neurohypophysis. In specimens evaluated macroscopically after 12 weeks, the corresponding rates for the test group were 12/12 compared with 0/13. Oxygen consumption in work as an index of cardio-circulatory function

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Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors. Micronuclei are induced in rat spermatids in vitro by 1,2,3,4-diepoxybutane but not by 1,2-epoxy-3-butene and 1,2-dihydroxy-3,4-epoxybutane.

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Traditional accounts of vocabulary acquisition assume that children succeed by aligning the utterance of words with their environmental contingencies, a word-to-world pairing. Comparing recombinant forms of onconase and a onconase-human RNase chimera shows that the N-terminal 9 amino acids and the pyroglutamyl residue of onconase are required for full anti-viral activity. Using Visualization of t-Distributed Stochastic Neighbor Embedding To Identify Immune Cell Subsets in Mouse Tumors. A premature newborn was first transported via helicopter from place of birth to a specialty nursery 50 years ago. Infertile men (study group) and donors (control group) were examined.

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In this way, galactomannans with regular, blockwise, and randomly distributed galactose could be discerned. This review article describes the significant recent advances in the analysis of proteins by capillary and microchip electrophoresis during the period from mid-2014 to early 2017. The bodies of most teleost fish species are covered with specialized subepithelial structures known as scales.

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This effect was significantly attenuated by pretreatment with -opioid receptor agonists U50,488H (1.0 mg/kg, s.c.) and TRK-820 (0.03 mg/kg, s.c.). Mutations within the basic domains of Fos and Jun abrogated binding to Tat in the in vitro assays.

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Immunohistochemical and ultrastructural analyses of cytoplasmic blood plasma inclusions of rat hepatocytes. Involvement of calcium-calmodulin-dependent protein kinase II in endothelin receptor expression in rat cerebral arteries. Serum glucose and liver glycogen levels were also estimated under both conditions. Finite element stress analysis of dental prostheses supported by straight and angled implants.

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The special attention is given to some physicochemical aspects of drug formulation which are essential for overcoming the air-blood barrier present in the lungs. Dynamically interacting processes underlie synaptic plasticity in a feedback pathway.