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This article provides a synthesis of research on the application of human factors to the design and development of the electronic health record and makes apparent the need for human factors education for nurses and IT professionals involved in EHR design. In order to exploit the tumour-specific nature of ERBB2 expression for genetic prodrug-activation therapy, we have generated recombinant adenoviral, retroviral and plasmid vectors containing an expression cassette consisting of the ERBB2 promoter and herpes simplex virus thymidine kinase coding sequence. To assess the variability of free-flow studies in men presenting with lower urinary tract symptoms (LUTS) suggestive of benign prostatic obstruction (BPO) and to determine the sensitivity, specificity and predictive values of consecutive measurements of maximum flow rate for the presence of bladder outlet obstruction (BOO) at several threshold values. These results demonstrate that 3-methylindole pneumotoxicity does not proceed by a mechanism of lipid peroxidation, but in fact, this molecule may act as an effective antioxidant to prevent lipid peroxidation in pulmonary tissue. Substitute and supplementary methods for the study of drug biotransformation

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Analysis and in situ mapping of the Adh locus in species of the willistoni group of Drosophila. A pH test may help with diagnosis as vaginal pH will be increased from acidic to neutral. Low-dose CT is effective and accurate for diagnosing acute appendicitis in childhood, as well as in adolescents and young adults.

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These studies have established the existence of an important functional relationship between transporter activity and presynaptic quantal neurosecretion. Involvement of DNA topoisomerase IIbeta in neuronal differentiation. Use of effort testing is limited to evaluation of antiarrhythmic effects of drugs in major dysrythmias and in some frequency-dependent dysrythmias, but this technique allows also detection of proarrhythmic incidence in those extremely altered autonomic nervous system tone. Amino acid compositions of the components from 6N HCl-solubilized collagen.

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The films were computer analyzed for spinal and dural parameters. The above results indicate that repeated psychostimulants enhance the activity of the hypothalamo-pituitary-adrenal (HPA) axis and lead to a decrease in the hypothalamo-pituitary-gonadal (HPG) axis activity. Experimental and simulated neon spectra in the 10-nm wavelength region from tokamak and reversed field pinch plasmas.

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Herpetic infection should be considered in pemphigus vulgaris with lack of improvement under adequate immunosuppressive therapy. During the postoperative course, multiple inappropriate discharges caused by myopotential oversensing indicated the relocation of the electrode and, finally, insertion of two epicardial leads by a left submammarian thoracotomy approach, produced an optimal result. The submandibular salivary gland (SMG) in the rodent is a rich source of growth factors. The Red Palm Weevil (RPW) Rhynchophorus ferrugineus (Oliver) is one of the most damaging invasive insect species in the world.

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Red light-induced appearance of phosphotyrosine-like epitopes on nuclear proteins from pea (Pisum sativum L.) plumules. Intensive diabetes management decreases Na-Li countertransport in young subjects with type 1 diabetes and enlarged kidneys.

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There are risks associated with fluid therapy, especially iatrogenic hyponatraemia. 1) They may either produce a specific protein matrix and be converted into melanin in the classical way, or 2) alternatively, a matrix resulting from lysosomal protein degradation or endocytotic pathways may be used and converted into melanin, as found in fibroblasts transfected with the tyrosinase gen or in Kupffer cells.

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Suppression subtractive hybridization identified differentially expressed genes in colorectal cancer: microRNA-451a as a novel colorectal cancer-related gene. witnessing violence, physical neglect, emotional abuse, physical abuse, sexual abuse) in relationship to compulsive buying as assessed by the Compulsive Buying Scale (CBS). Responding neutrophils and monocytes were prepared on conventional density gradients, and in three instances, the chemotaxis of eosinophils isolated on metrizamide gradients was also studied. This led to sequencing of WDR62, a gene that codes for a spindle pole protein recently identified as a cause of primary microcephaly.

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The eruptions were typical of the superficial form of EAC, both clinically and histopathologically. Hodgkin and Reed-Sternberg cells do not carry T-cell receptor gamma gene rearrangements: evidence from single-cell polymerase chain reaction examination. An integral approach is offered, which helps detect the contribution of various age groups to total mortality. Using the cDNA-AFLP technique, 30 hrpG-induced (hgi) and five hrpG-repressed (hgr) cDNA fragments were identified, defining a large hrpG-regulon in X.

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The interaction of sildenafil with the anticonvulsant effect of diazepam. Fifty-one women with stage I endometrial cancer followed for 1 year. The system time lag of CGM system was estimated using various regression method related statistical estimators. Responses to possession and insanity in the earlier Byzantine world.

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In the present study, we investigated a series of bronchoalveolar (BAL) and blood samples, collected in the absence of rejection or acute infectious episodes. In contrast, anti-60 kDa antibodies were, with rare exception, confined to IgG1. Ultrasonographic evaluation of the gastric emptying and cholecystic volumes was performed before and after mineral water and top water drinks at settled intervals. Northern hybridization analysis showed only one transcript for trpF (about 700 nucleotides). Light and electron microscopic examination of the islets of Langerhans from treated mice revealed an early chromatin aggregation and cytoplasmic vesiculation in the central B cells during the first 2 h of treatment.

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Corrigendum: Functional solid additive modified PEDOT:PSS as an anode buffer layer for enhanced photovoltaic performance and stability in polymer solar cells. The probability of the outcome of the study being due to chance alone is considered very small, especially taking into account the fact that RA is a chronic progressive disease. Postoperative adhesion formation after urological laparoscopy in the pediatric population. She experienced seizures with loss of consciousness for 1 month prior to diagnosis.

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However, in unsuccessful cases, such fluctuation was not so clear as the successful cases. RO5166017 had no effect on the reconsolidation of cocaine reward memory.

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The therapeutic response and side effect profile of the different doses favoured 30 mg phenolphthalein as the optimum laxative dose. Because it contains relatively few neoplastic cells relative to the amount of mucin produced, diagnosis of this entity, particularly on small specimens, is exceedingly difficult. To facilitate clinical research at the Regional Trauma Unit at Sunnybrook Medical Centre in Toronto, it was decided to attempt to improve the quality and quantity of clinical patient information obtained at initial assessment in the Trauma Room. Using this system, observational data were collected in a self-contained classroom for a mentally retarded adolescent (Experiment 1) and in a remedial summer school classroom for a regular first-grade student (Experiment 2). Because of renal failure, he underwent hemodialysis and passed away due to myocardial infarction in 1993.

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It suggests that a partial tear of the posterior half of the ligament may be difficult to detect clinically. Since the rare tryptophan residue is generally engaged in structural roles in proteins, or when exposed serves as binding sites, we surmise that its exposure in the amyloidogenic fragments allows for intermolecular clustering with residues from other molecules leading to the formation of amyloid aggregates. Data were collected from sports vision screenings conducted from 1992 to 1995.

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In this study we estimated the biological accessibility and the degree of biological accessibility of calcitonin in relation to highly specific marker-osteocalcin after a single intraperitoneal administration. Recovery of total peripheral erythrocyte numbers and total peripheral leukocyte numbers occurred within 72 hr postphlebotomy in both treatment groups. The burned animals cooled 1.9-3.5 times faster at 22 degrees than at 28 degrees C, and controls cooled 2.0-3.9 times faster at 22 degrees than at 28 degrees C.

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In 4 patients, conduction block could be recorded only in proximal nerve segments or spinal roots. Leptospires in the whistling frog (Eleutherodactylus johnstonei) on Barbados. We evaluate statistical metrics for temporal change in the frequency of individual SNPs, assuming that SNPs associated with resistance increase in frequency over this period. Exact tests for gene order are derived and compared for three loci using linkage data from phase-known, completely informative marker loci (i.e. Potential barriers to success arise in three areas-strategy, finance, and operations.

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Kinases for the synthesis of coenzyme A and triphosphopyridine nucleotide. Cultured nonparenchymatous liver cells of mice produce both thermostable and thermolabile factors to influence oxygen-dependent metabolism, degranulation and phagocytosis of neutrophils. Seven different known etiological agents causing respiratory symptoms were used for experiments: cell extract and endotoxin from Pantoea agglomerans (synonyms: Erwinia herbicola, Enterobacter agglomerans), cell extracts from Thermoactinomyces vulgaris and Aspergillus fumigatus, protease from Bacillus thermoproteolyticus rokko and two preparations of glucans. Commentary on: Cosmetic Liposuction: Preoperative Risk Factors, Major Complication Rates, and Safety of Combined Procedures. The metabolism of astaxanthin during the embryonic development of the crayfish Astacus leptodactylus Eschscholtz (Crustacea, Astacidea).

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This enzyme converts tetrachlorohydroquinone (TCHQ) to trichlorohydroquinone (TriCHQ) and TriCHQ to dichlorohydroquinone (DCHQ) (Xun et al. A 26 year old woman presented with a 4-year history of a gradually enlarging fluctuant mass on the left labium majus. In contrast, increased chemical nonideality and eventual hemolysis are the likely factors responsible for the behavior in the hypertonic range. Remote controlled prolonged conscious sedation for gynaecological radiotherapy.

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The literature dealing with health and entrepreneurship has focused on developed countries. A 28-cm (SFOV) camera was fitted with slant-hole and diverging collimators to perform craniocaudal scintigraphy for direct comparison with mammography. This type of repair can be a useful addition to the surgical armamentarium in mitral valve reconstruction. Results are generally successful when uveitis is not severe and the posterior segment can be carefully observed after cataract surgery.

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A decisional balance measure was developed using item generation and development, pilot testing, and principal components analyses. The distributions of biotin-reactive puncta were observed in laboratory-housed frogs and in wild toads captured in the summer months but were sparse or absent in batches of commercially obtained frogs examined immediately upon arrival in the laboratory. Hysteria and insanity in women: a nineteenth-century Canadian perspective. One of the surrogates is new, and has been specifically designed to preserve the shape of the attractor. Although early detection and treatment of prostate cancer is widely advocated, this so-called secondary prevention approach has a number of drawbacks.

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Motilin levels were higher in patients and differences in the subgroups were observed. We further demonstrated the utility of this model at the clinical setting, as a reliable prognosis tool to determine progression-free survival in mCRC patients. Therefore, the present study aimed to analyze the relationship between CYP2D6 genotype and personality, cognition and psychopathological vulnerability. The present study compared the performance, i.e., number of substitutions completed accurately and number of errors, of 37 adults, 32 adolescents, and 45 children on the Wechsler symbol-substitution tests of Digit Symbol and Coding with their performance on the recently designed Symbol-Symbol test. This article discusses the advantages and disadvantages of a cross-section of these expression systems, how they compare with established systems and how they can be applied to the industrial-scale production of recombinant proteins.

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The Internet is a global communication network used by more than 17.6 million adults as a major source of current health information. However, mice immunized with neuraminidase mutants containing multiple amino acid substitutions showed a reduced protection rate against heterologous virus in comparison with the reference groups. The potential for radiation recall toxicity should be considered in treatment decisions pertaining to patients with AIDS-associated KS.

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Present study aims to characterize the association between anatomical and functional deficits in MCI patients. In both glands, western blot analysis with anti-connexin 32 and 43 antibodies revealed bands of about 27kD and 43kD, respectively. Evidence for Community Transmission of Community-Associated but Not Health-Care-Associated Methicillin-Resistant Staphylococcus Aureus Strains Linked to Social and Material Deprivation: Spatial Analysis of Cross-sectional Data. Developmental dysplasia of the hip (DDH) is a spectrum of abnormalities that can range from a very mild disturbance to a very severe process that is incapacitating later in life. Treatment should be individualized, but clomiphene citrate is an excellent first-line agent.

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These results demonstrate that a lower concentration of DMSO (1.5 M) allows for the cryopreservation of human islets with superior survival and preservation of function post-culture compared with 2.0 M of DMSO and various concentrations of EG. To correlate the conspicuity of hepatocellular carcinomas and dysplastic nodules on ferumoxides-enhanced magnetic resonance (MR) images with the number of Kupffer cells in the hepatic lesions, as compared with that in background liver in histopathologic findings. Malondialdehyde as an indicator of lipid peroxidation and antioxidant enzymes including superoxide dismutase, catalase, and glutathione peroxidase were measured in plasma respectively. All 5 patients had heart failure symptoms and electrocardiogram was abnormal.

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It is emphasized that intra-articular ridges and depressions can be misinterpreted roentgenologically as osteophytes. This study demonstrates the utility of combined epidemiologic and laboratory techniques in identifying a novel common source for a C. Any increase in glargine dose was coupled with a reduction in the dose of any regular or rapid-acting insulin analogue as far as possible while maintaining a constant daily insulin dose. Nonergodicity transitions in colloidal suspensions with attractive interactions. The present study characterized the influence of 3T3-CM on breast cancer cell motility and examined the hypothesis that antiestrogens inhibit this 3T3-CM-induced effect.

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The differential response to caffeine of ataxia telangiectasia and control lymphocytes may be explained by the presence of two different subpathways in the G(2) checkpoint: one regulating the processing and repair of damaged DNA and the other controlling G(2) timing. The Rett-syndrome-associated methyl-CpG-binding protein 2 (MeCP2) selectively binds methylated DNA to regulate transcription during the development of mature neurons. Infection with HCV is associated with several autoimmune neurological manifestations. Identification of two binding domains, one for peptidoglycan and another for a secondary cell wall polymer, on the N-terminal part of the S-layer protein SbsB from Bacillus stearothermophilus PV72/p2. Brain subjected to acute ischemic attack caused by an arterial blockage needs immediate arterial recanalization.

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African monkey, presented fibroblasts-like cells and growth in monolayers. We employed parametric stimulus sets containing natural images and noise patterns matched for spatial frequency and intensity as well as intermediate images generated by interpolation between natural images and noise patterns. However, nonspecific protein adsorption leaves a great challenge in drug delivery of intravenous administration and significantly affects both the pharmacokinetic profiles of the carrier and drugs, resulting in negatively affect of therapeutic efficiency.

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Gene expression profiles of two B-complex disparate, genetically inbred Fayoumi chicken lines that differ in susceptibility to Eimeria maxima. Adaptation of electromyographic analysis to psychological testing problems

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TSG-6 exerts an anti-inflammatory function by counteracting the transcription of MMP-1 and MMP-3 and the activation of MMP-1. These networks are identified here as endoplasmic reticulum by the presence of ER resident proteins, as shown by immunofluorescence, and by the presence of single ribosomes and polysomes, as shown by electron microscopy. Histologic data regarding the new bioresorbable collagen barrier itself and the time range in which the collagen device functioned as a barrier are still lacking, and the studies are currently being conducted. The 2-step method has no clear advantages compared with the 2-item screen alone or the 9-item screen alone for predicting adverse prognostic effects of depressive symptoms in heart failure.

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The effect of vesicle formation was reversible if the cells were placed in fresh medium lacking detergent. There seems to be a trend towards shorter immobilization time and early range of motion, although there is no consensus in the literature on best practice recommendations for optimizing rehabilitation after surgical repair of peroneal tendon tears or ruptures. Food and Drug Administration for chronic intrathecal infusion for the treatment of chronic pain is morphine sulfate.

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Replication-deficient adenoviral recombinants were assessed for in vivo transduction of rat hippocampal CA1 cells. The ethics of placebo-controlled trials in developing countries to prevent mother-to-child transmission of HIV. Opiate-negative urines and naltrexone ingestion were rewarded with monetary vouchers. Although most births occur in hospitals, there has been an increase in requests for home and birth center births. Quantitative assessment of image-guided radiotherapy for paraspinal tumors.

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Heparins stop adhesion of leucocytes to endothelial cells, they are anti-complementary, they modulate the activities of phagocytes and they stop the proliferation of mesangial cells or vascular smooth muscle cells. The search for pure antigens avoiding such cross-reactions is in progress. Human Visual System as a Double-Slit Single Photon Interference Sensor: A Comparison between Modellistic and Biophysical Tests.

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Secondary endpoints were various hemoglobin (Hb) levels, change in Hb between time points, length of stay, iron status, morbidity, mortality, and quality of life 4 weeks postsurgery. Fructose consumption has been recently related to an epidemic of metabolic syndrome, and hyperuricemia plays a pathogenic role in fructose-induced metabolic syndrome. There are fewer studies of noradrenergic function in the other anxiety disorders, and the findings there have not been consistent.

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Using a thrombin cleavage assay in cultured hippocampal neurons, we studied the kinetics, regulation and site of AMPA receptor surface delivery. The 90-item inventory is designed to assess psychosocial stress associated with problems in daily living with diabetes. Potent and selective dipeptidyl boronic acid proteasome inhibitors are described. Opposite variations of cAMP levels and LPL activity were only observed in WAT following high fat diet administration.