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Role of hydrophobic core on the thermal stability of proteins - molecular dynamics simulations on a single point mutant of Sso7d abstract. This would suggest that the guinea-pig diaphragm would be the most appropriate bioassay preparation if only small quantities of drug were available. Effect of soybean phosphatide on blood coagulation defect following total body x-irradiation in the dog.

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Effects of motilin on human interdigestive gastrointestinal and gallbladder motility, and involvement of 5HT3 receptors. Positive samples (160) and randomly selected negative samples (52) by both RDT and LM were further analysed using 18S rRNA-based nested PCR. To address this issue, we present a de Bruijn graph-based heuristic clustering method (DBH) for clustering massive 16S rRNA sequences into OTUs by introducing a novel seed selection strategy and greedy clustering approach.

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Staphylococcus aureus was the causative organism in nearly 100 percent of the cases. The resulting error-containing products may overload chaperone systems. We now report the multicomponent reaction (MCR) of in situ-generated 1-azadienes with carbon disulfide. Two lead compounds were found that cleared the mice of bacilli in acute infection and caused a 2.29-2.99 log reduction in cfu of persistent bacilli.

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For subsequent in vivo studies, saline was injected as a bolus before RF application or continuously (1 mL/min) during RF application. The end of hostilities brings such a sense of relief that we are inclined to want to put the experience behind us. Kinetic and thermodynamic analysis of taxol-induced polymerization of purified tubulin. N,N-diethylbutyramide (DBA) and 1-methyl-1,2,5,6-tetrahydropyridine-3-(N,N-diethylcarboxamide) (THPC) were also tested.

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The quality of gasoline and diesel fuel affects pollutant emissions from vehicles. To evaluate the penile echo Doppler study and review the anatomy, perfusion, innervation and physiology of erection. The effect of a kappa-receptor agonist U-50, 488H on urine flow and the activity of TH-IR (tyrosine hydroxylase-immunoreactivity) neurons in PVH (Paraventricular neucleus of the hypothalamus) was studied in ethanol-anesthetized rats.

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Reliability of global rating scales in the assessment of clinical competence of medical students. Autoimmune involvement in CNS trauma is beneficial if well controlled. Using the residual gas analyzer, the average mercury vapor pressures measured from the as-formed and abraded dental amalgam surfaces were 8 x 10(-7) and 1.7 x 10(-4) Pa, respectively.

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Morphine and indomethacin were used as representative opioid and non-steroidal analgesics respectively. The association of max-IMT with coronary artery stenosis assessed by coronary computed tomography angiography and the incremental effect of adding max-IMT to the conventional risk factors for predicting coronary artery stenosis were evaluated in 241 asymptomatic type 2 diabetic patients. This article presents the case of a patient who had undergone surgery for treatment of a tumor of the hypophysis involving intraoral access to the sella turcica.

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Ninety-two cases, diagnosed as acromegaly, were selected as research subjects from January 2013 to December 2013 in Peking Union Medical College Hospital. The enhancer of hepatitis B (HBV) virus displays a liver-specific activity that determines the postreceptor virus-host tropism. These may reflect differences in cellular sensitivity or multiple sites of action of the drug, and the existence of a specific molecular target for BFA is questioned. We tested these models in the Australian cricket, Teleogryllus oceanicus, using a design that allowed us to partition additive, nonadditive genetic, and parental variance for sperm competitiveness. Asthma--the shift from episodic treatment to ongoing prevention, education, and management.

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Implications for ecological assessment of community social and physical environments are discussed. Hippocampal proliferation showed a tendency to decrease in L-NIL-treated animals that did not reach statistical significance. Selective adenomectomy was recommended when an adenoma was found during surgery, and partial or hemihypophysectomy when no adenoma was found. The value of toxicologic screens, emergency department endotracheal intubations, gastric lavage, and charcoal/cathartic therapy is discussed.

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A multi-centre study in four African countries was undertaken to test the acceptability and effectiveness of Health Workers for Change, a methodology to explore provider-client relations within a gender-sensitive context. Detection, visualization and animation of abnormal anatomic structure with a deformable probabilistic brain atlas based on random vector field transformations. This article has two goals: (a) to establish whether, based on observed responses, it can be decided that an underlying latent variable is continuous or categorical, and (b) to quantify the effect of sample size and class proportions on making this distinction. Effect of steroids and nonsteroidal anti-inflammatory agents on stromal wound healing following excimer laser keratectomy in rabbits.

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There is powerful inhibition of early differentiation without cell toxicity by pADPRT ligands. A case of a duodenal and a pancreatic pleomorphic sarcoma which was diagnosed as a malignant undifferentiated neoplasm cytologically is described. Excellent quantitation and lane-to-lane migration time reproducibility were found for all the solute components using the multilane separation platform.

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We argue that genetically produced variability in serotonin reuptake during stressor-induced raphe-raphe interactions alters the balance in the amygdala-ventromedial prefrontal cortex (VMPFC)-DR circuitry underlying stressor reactivity and emotion regulation. Hence, there were no special restrictions on collecting ocular tissues from donors with a diagnosis of metastatic melanoma. Such networks can solve classification problems with ill-defined categories in which the patterns are deeply hidden within the data, and models of behavior are not well defined.

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Security giving in surrogacy motherhood process as a caring model for commissioning mothers: A theory synthesis. Further, the pattern of E1G excretion was compared with ultrasound assessment of follicular growth. The p53 and nm23-H1 genes are not deleted in oral benign epithelial lesions. Nitrous oxide (N2O), laughing gas for anesthesia, is generated endogenously through NO reductase in bacteria and fungi, and has recently been shown to modulate N-methyl-D-aspartic acid (NMDA) receptor function.

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txyA consists of a 1,410-bp open reading frame that encodes 469 amino acid residues with a calculated molecular mass of 52,256 Da. The testing method might be used to evaluate the protective performance of the canister against microbiological aerosol. Effects of unsaturated fatty acids on the peroxisomal enzyme activities of Tetrahymena pyriformis.

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The cost of running a multidisciplinary head and neck oncology service--an audit. It may also play a role in cellular development and differentiation, and represents a site of action of hallucinogens and certain psychotherapeutic drugs. acnes is an indolent organism that may rarely cause severe intracranial infections. The stress involved repeated cycles of a 1-h direct exposure to a larger aggressive C57Bl6 breeder mouse followed by a 23-h period of barrier separation over 4 wk. In situ terminal deoxynucleotidyl transferase-mediated nick end-labeling assay revealed that apoptosis mainly occurred in the cerebral white matter of the irradiated hemisphere.

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None of the patients had metastases and all tumours were well differentiated squamous cell carcinomas. Why mothers are variably affected by mood symptoms postpartum remains unclear, and the pathogenesis and early molecular indicators of this divergent outcome have not been described. A half-century later, the most we know about his life comes from his widow. The intervention should be considered for use in other nursing and residential homes. Establishing guidelines for the identification of occupational injuries: a systematic appraisal.

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Concerning the PVT, weak variations in specific binding were detected in SP only when time points were grouped according to the light or dark periods. Self-report and consultation data provide comparable estimates of the prevalence of specific diagnoses such as diabetes. Cranial vascular effects of zolmitriptan, a centrally active 5-HT1B/1D receptor partial agonist for the acute treatment of migraine. The presence of cytomegalovirus antigens in karyotyped abortions.

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Local ischemic changes are manifested on spin echo MR examination as loci of increased signal intensity, most likely representing accumulation of local myocardial edema. Therefore, we have identified a distinct apoptotic cascade in SW620 cells that was induced independently of growth arrest, dissipation of the deltapsim, ROS production, or synthesis of de novo RNA or protein, and we have linked its efficient initiation to early elevation of the deltapsim.

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The oxygen consumption rate of fed female ticks was significantly higher than that of fed males but, there was no significant difference between the oxygen consumption rates of starved female versus starved male ticks. Overweight figures were assigned low rankings for all these qualities except reproductive capability. This was a retrospective cohort study designed to evaluate the rates of recurrent preeclampsia among women with a history of preeclampsia. Volunteer subjects with previous histories of cocaine use were administered cocaine hydrochloride intravenously or intranasally. A multiple adjustment procedure yield 3 year case fatality rates of 27.1 percent and 28.3 percent, respectively, for patients with transmural and nontransmural myocardial infarction surviving the acute phase.

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The MLL (Mixed Lineage Leukemia) gene is a common target for chromosomal translocations associated with human acute leukemias. A drier environment at this locality and weather conditions immediately prior to collection, most likely explain the reduced size. Enantiomeric ratio of shikonin derivatives as a possible key for the determination of the origin of lithospermi radix. Age-related changes in vitreous mobility as measured by video B scan ultrasound. Cataract was shown to be associated with riboflavin deficiency in animals in the 1930s and subsequently with deficiencies of amino acids, vitamins and some minerals.

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Although opinions differ to some extent there is increasing belief in the value of monitoring plasma levels for effective therapy with neuropsychiatric drugs, especially with anticonvulsants. Nonmyeloablative allogeneic stem-cell transplantation is feasible for a minority of patients with metastatic RCC. To understand the molecular mechanisms that sustain adult neurons, we established low density, glial cell-free cultures of 12-wk rat superior cervical ganglion neurons and manipulated the function and/or expression of key proteins implicated in regulating cell survival.

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Total protein extracts were separated by two-dimensional gel electrophoresis (2-DE), 895 spots were analyzed by MALDI-TOF mass spectrometry (MS), and 286 were identified as leptospiral proteins, corresponding to 108 distinct proteins. However, among patients grouped by weekly CCr, there was no significant difference in any of the eight domains of the SF-36 between patients in the adequate and inadequate groups. This raises the problem of the necessity to experiment inflight (injections, sacrifice) in order to avoid the recovery effects of the few hours following the landing.

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Most regulation of MHC class II molecule expression is under the control of transcription mechanisms which are both cell type and development specific. Patient-related factors included health literacy, fear/denial, family experiences and self-efficacy. Hypertrophic Z-line observed in aged one-humped camel (Camelus dromedarius).

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Persistence of immunoglobulin M or immunoglobulin G antibody responses to Borrelia burgdorferi 10-20 years after active Lyme disease. A national database was utilized to assess patient characteristics, surgical procedures, and outcomes of degenerative spinal surgery in Finland. No complications occurred and the mean minimal thickness of the skull base between middle cranial fossa and reconstructed glenoid fossa was 1.97 mm. Retinal wholemounts were immunostained with AQP1 and AQP4 antibody to detect the immunolocalization changes by confocal microscopy. When the H441A or H441N mutation was introduced, both the oxidase and isomerase activities were completely lost.

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MMN is a negative component resulting from the difference in event-related potential (ERP) waveforms elicited by a standard and a deviant stimulus. PCR-restriction enzyme analysis of a bone marrow isolate from a human immunodeficiency virus-positive patient discloses polyclonal infection with two Mycobacterium avium strains. Increased expression was also observed in the suprabasal layers of dysplastic oral epithelia and in well-differentiated squamous cell carcinoma, but not in basal cell carcinoma.

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Mechanisms other than penicillin-binding protein-2 alterations may contribute to moderate penicillin resistance in Neisseria meningitidis. However, interapophyseal regions (IARs) remained devoid of new bone, such that true bony bridging of adjacent transverse apophyses (true SF) could not be achieved.

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The periodontal health scores at the 16-week interval serve as the baseline to measure subsequent changes in periodontal health.(ABSTRACT TRUNCATED AT 400 WORDS) The relationship between free radicals and scavenger enzymes, and the disorders called the neuronal ceroid-lipofuscinoses, has long been an argumentative one.

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A 21-year-old gentleman, a worker in a mobile phone shop, was admitted with rhabdomyolysis, renal failure, and pulmonary edema requiring mechanical ventilation and hemodialysis. Postoperative problems include dizziness, tinnitus, facial nerve spasm, receiver-stimulator migration or extrusion, infection of the scalp flap, and facial nerve palsy. It was concluded photogrammetry then be reliable, accurate and efficient for carrying out anthropometric surveys of population, and presents less difficulty to collect in-place.

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In conclusion, this study provides insights into the use of chitosan as a gene delivery system. A 41-year-old woman presented with an asymptomatic pelvic mass and rising levels of serum CA-125. A triangulated technique of data validation through cross verification from 3 subsets of respondents was used: 160 ward development committee (WDC) members, 8 officers-in-charge (OICs) of PHCs, and 383 beneficiaries (health facility users) participated. Peripheral somatic nerve function in relation to glucose tolerance in an elderly Caucasian population: the Hoorn study.

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The conception of human subjectivity vis-a-vis the basic concepts of theoretical and practical medicine Of all substances studied only vasoactive intestinal polypeptide was found in principal ganglionic neurons. Four had hypopigmentation, and three of these four had abnormal evoked potentials indistinguishable from those recorded in human albinos. Experimental pulmonary metastases have been successfully treated by adoptive transfer of tumor-sensitized T cells from perforin knockout (KO) or Fas/APO-1 ligand(KO) mice, suggesting a prominent role for secretion of cytokines such as IFN-gamma.

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All hamsters maintained circadian rhythms of wheel-running activity. Review of French tools: Non-dimensional approach and self-assessment Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids.

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Alterations of pRb and p16INK4 expression are frequently involved in extrahepatic bile duct carcinomas, and that aberrant pRb expression significantly associates with tumor progression. The aim of our study was estimation of frequency of occurrence endometriosis at girls operated from different indications, research of predisposing factors and estimation of selected biophysical parameters. Neural prostheses use electrical stimulation to activate paralyzed muscle. The study was carried out to assess the effect of nitric oxide (NO) generation or inhibition of NO synthase on the cardiac response to beta- and alpha 1-adrenergic agonists. The high degree of asymptomatic shedding of live adenovirus in non-human primates and evidence for zoonotic transmissions warrants caution for primate handling and housing.

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This was corroborated by neurophysiological evidence of reduced slow-wave EEG amplitude in the ZDV-treated subjects. Subtle patterns and ranges of motion between segments of the foot were consistently detected. Photocatalytic bactericidal action of fluorescent light in a titanium dioxide particle mixture: an in vitro study. We also detect clear population differentiation and population structure within Sweden into a southern and a northern cluster. A1 5 x 10(-7) M, SiPc and PcHEX induced a significant photokilling, whereas NiPc and PcPHE were inactive.

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However, unlike other LPS(d) strains, the Cr strain also has a heavily impaired IFN-gamma response to micro-organisms. We use the outline structure to investigate the likely effects of 22 mutations that cause neurological diseases.

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Appearance of the endometrium on light microscopy, pinopode formation, serum levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH), and expression of progesterone receptors A and B and estrogen receptors alpha and beta. Experimental data indicate that perceptual decision making involves integration of sensory evidence in certain cortical areas. The authors have developed and tested a method to decorrelate the spatial uncertainties and make statistical samples of highly correlated error maps.

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The peptide identification problem lies at the heart of modern proteomic methodology, from which the presence of a particular protein or proteins in a sample may be inferred. STUDY DESIGN / METHODS: A cross-sectional observational survey was used in this study. At the same time the disease in immunocompromised individuals may be severe, presenting with viremia, evolving sepsis, and high death rates.