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Direct and indirect association of the small GTPase ran with nuclear pore proteins and soluble transport factors: studies in Xenopus laevis egg extracts. This observed treatment effect may be related to the inhibition of TNFalpha production and processing in the synovium. Exploration, social investigation, eating, and immobility were differentially affected by the drug treatment, depending on screening and/or intruder sex condition. Natural killer (NK) and cytotoxic T lymphocyte (CTL) activities were markedly enhanced in the mice transfected with the cytokine genes.

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The concurrent validity and reliability of the Japanese version of AUDIT were evaluated in a complete health examination. Retinopathy improvement and worsening were determined during 2 years of treatment. Diseases of the temporal bone causing lower cranial nerve palsies are uncommon. Expression of type XII collagen by wound epithelial, mesenchymal, and ependymal cells during blastema formation in regenerating newt (Notophthalmus viridescens) tails.

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This association correlates with the appearance of PI 3-kinase enzymatic activity in CD28 immunoprecipitates and the formation of D-3 phosphoinositides. Is Brain Activity during Action Observation Modulated by the Perceived Fairness of the Actor?

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Practical guidelines for the diagnosis of acute pancreatitis are presented so that a rapid and adequate diagnosis can be made. Simultaneous electrical recording of cardiac electrophysiology and contraction on chip. Chromosomal abnormalities and gene amplification in renal cancers induced in rats by nickel subsulfide. Telomerase activity was detected, though very weakly, in cultured normal epidermal keratinocytes and at higher levels in a subpopulation that adhere rapidly on collagen IV-coated culture dishes. Qualitatively the same AA-DNA adduct patterns were observed, although at lower levels, upon incubation of AAs with renal cytosol.

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Basal and HCG-stimulated testosterone production by interstitial cells of the Mongolian gerbil (Meriones unguiculatus)--II. In conclusion, we provide the evidence for a specific ceramidase other than pancreatic BSSL present in the intestinal content. In vitro intestinal cell studies have shown that mitogen-activated protein kinase (MAPK) signaling is an important modulator of intestinal inflammation. Two aquaporins have been identified so far in the CNS, AQP1 and AQP4.

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Single cones display a slightly tapered outer segment, a large electron lucent oil droplet and an ellipsoid of mitochondria in the apex of the inner segment. The variables that significantly correlated with early death were the severity of limb paresis, infarct size, electrocardiographic abnormalities, the level of consciousness, electroencephalographic abnormalities and hyperglycemia. Differences were reduced by waveform filtering from 3 (SD 9)mmHg at rest to 1 (SD 15)mmHg at maximal exertion. Moreover, the effect of temperature (between 8 degrees C and 38 degrees C) on CO binding kinetics has been investigated in the absence of ATP at different pH values. The biologic activities of interleukin (IL)-13 and IL-4 often overlap, and evidence supports their importance in atopic disease and airways hyperresponsiveness.

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Donor plasma and platelets interfered with the induction of this tolerance. The molecular factors involved in the mutation process from stable (CGG)(n) alleles towards unstable alleles are largely unknown, although family transmission studies and population studies have suggested that loss of AGG interruptions in the (CGG)(n) repeat is essential. Influence of vitamin D3 deficiency and 1,25 dihydroxyvitamin D3 on de novo insulin biosynthesis in the islets of the rat endocrine pancreas. Seven key lessons are developed using examples from family planning where scaling up was an explicit objective, including the early Taichung Study of Taiwan, the Chinese Experiment in Quality of Care, the Bangladesh MCH-FP Extension Project, the Navrongo Project in Ghana, and the Reprolatina Project in Brazil. In this article, the authors discuss extracorporeal CO2 removal, venovenous intravena caval oxygenator, and tracheal gas insufflation as adjuncts to CO2 removal and nitric oxide, surfactant replacement therapy, perfluorocarbon-associated gas exchange, and prone positioning as adjuncts to oxygenation.

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The three sub-scales (Confounders, Risk, and a parameter of Alliance) showed excellent content validity. Further studies to develop course-embedded assessment systems for other program outcomes in nursing education are needed.

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Formal clinical comparisons between the various treatment options are necessary to assist the clinician in selecting the appropriate form of therapy. Choosing sides: establishment of polarity in zygotes of fucoid algae. These results demonstrate that GGT is a component of widely distributed TM4 complexes, and that on B cells the GGT-containing TM4 complexes also contain CD19 and CD21. Skin substitutes prepared from cultured skin cells and biopolymers may reduce requirements for donor skin autograft, and have been shown to be effective in treatment of excised burns, burn scars, and congenital skin lesions.

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To identify the overall reoperation rate and factors contributing to reoperation in a recent 5-year cohort of patients (2003-2007) undergoing spinal deformity surgery. As health care is being reformed, the risk for and cost of occupationally acquired infection must be considered. The models are systems of differential equations describing the interaction of the HIV infected immune system with AZT chemotherapy. MCAT might be responsible for the rate enhancement of malonyl transfer at very low free holo-ACP concentrations or it could be required to catalyse the transfer of malonyl groups from malonyl CoA to sequestered holo-ACP.

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The other organs showed neither gross pathological alteration nor weight change, compared with the control. The ACL surgical repair significantly alters lower-extremity gait patterns, and that the establishment of pre-injury gait patterns takes at least 9 months to occur.

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Nutrition support contributes to reducing morbidity and mortality in patients with the multiple-organ dysfunction syndrome (MODS). Differential gene expression observed in monocytic differentiation is primarily regulated by interacting transcription factors (TFs). Cytometric analysis and maturation characteristics of reticulocytes from myelodysplastic patients. A plethora of discoveries relating to sex influences on brain function is rapidly moving this field into the spotlight for most areas of neuroscience.

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We collected the postcode of every individual who died, and through this determined the socio-economic deprivation, urban-rural characteristics and region of their residence. The presence of coumarins in some clover species makes it imperative to include tests of clotting factors in future trials. Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. Preoperative magnetic resonance imaging revealed a well-demarcated, enhanced mass of 6 cm in diameter in the intradural extra-axial frontal region.

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No obvious inhibition is observed of other serine proteinase such as bovine trypsin, bovine chymotrypsin, subtilisin from Bacillus subtilis and cathepsin G from human leucocytes when tested with synthetic substrates. Determination of the point of congelation of the crystalline lens of the calf Services to help them remain in community are often fragmented, uncoordinated and limited. The latter were interpreted to distinguish different dynamical stages of the movement preparatory process.

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These data indicate that disruption of the p53 growth-regulatory pathway is not a prerequisite for the malignant conversion of rat embryo fibroblasts expressing the E7 gene and mutant ras. Long-term outcome in survivors is acceptable, particularly in the absence of brain stem infarction.

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This method for producing colored images is predestined for industrial mass production and will have ever more practical applications such as for security features. The clear appearance resulted from the presence of one or several of the following features, as the sole or predominant cause or in combination: glycogen, lipid droplets, mucin vacuoles or diffuse mucosubstances, dilated cisternae, swollen or unusually large mitochondria, large solitary membrane-limited vacuoles or numerous smaller vacuoles, intracytoplasmic lumens, expanded intercellular spaces, cytoplasmic pseudoinclusions, and a paucity of organelles. However, none of the patients who considered treatment with cryopreserved embryos as less effective ever thought of refusing this type of treatment or discussed this with medical staff. Close scrutiny of subtle changes in behavior can further help assess reptile well-being and judge captive welfare.

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The study of the drug transport performed by flow cytometry showed that L61 enhanced the drug uptake and reduced the P-glycoprotein-mediated drug efflux. To prospectively determine whether cardiac-gated multidetector computed tomography (CT) allows visualization of aortic valve leaflets after bioprosthetic aortic valve replacement (AVR), to provide an accurate method for measuring the aortic valve opening, and to provide morphologic and functional information regarding the mechanism underlying poor function of the bioprosthetic valve.

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The described method is suitable to be adapted to low-, medium-, and high-throughput screening and allows multiplexing with other cell fitness indicators. When he was 32 years old, he complained of heaviness in his lower extremities. Glutamate antagonists have been shown to be neuroprotective in animal models of cerebral ischemia. Spontaneous firing rates were significantly higher in reorganized areas than in normal areas.

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Endovascular stenting for treatment of superior vena cava syndrome. Rheumatic heart disease in dextrocardia with complete situs inversus.

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A study of the effects of a maternal child health curriculum on graduate student attitudes towards parent participation in the care of the pediatric patient. In this study, we discuss a mechanism of development of access-related Staphylococcus aureus infections in patients on buttonhole (BH) method and logically construct a measure to prevent such infections on the basis of the mechanism. Allele frequencies, characteristic DR/DQ linkage disequilibria, population distances and their corresponding dendrogram by using the Neighbor-Joining method were used to study relatedness between Jewish and other Mediterranean and non Mediterranean populations. Urocortin1 neurons became over-active in CMVS-exposed PACAP knock out (KO) mice with MD180 history, suggesting the contribution of centrally projecting Edinger-Westphal nucleus to the reduced depression and anxiety level of stressed KO mice.

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To address this, the effects of basic fibroblast growth factor (bFGF) on beta 1 integrin-mediated adhesion relative to migration in human microvessel endothelial cells (HMVEC) was examined. Current limitations of immunotherapy urgently require an efficient alternative with high safety, target affinity and more promising venom neutralizing capability. These three compartments and an stable preocular tear film are crucial factors determining ocular surface health. Ultraslow polaron dynamics in low-doped manganites from (139)La NMR-NQR and muon spin rotation. It may prove useful for researchers interested in examining semantic memory processes in cognitively impaired individuals.

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Three types of biological targets for the search of small-molecule active drugs are described: nucleic acids, enzymes, and RNA-protein complexes. A number of T cells recognize 48-61 with asparagine at position 59, but not the aspartic acid or isoaspartic acid derivatives.

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Current and future clinical applications of interferon-gamma in host antimicrobial defense. Secretin inhibits gastric secretion of acid and gastrin in dog and a physiological role of secretin as an enterogastrone has been suggested in this species. Young infants are susceptible to developmental factors influencing the pharmacokinetics of drugs. Gastroprotective effects of a new zinc(II)-curcumin complex against pylorus-ligature-induced gastric ulcer in rats.

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Comparative investigations of the phase analysis between bundle-branch heart block and Wolff-Parkinson-White syndrome. Pharmacological effects of various venoms on cutaneous capillary leakage. Means and covariances of the seven stress factors were compared between the derivation sample and an age-matched subset of the cross-validation sample.

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CaP-based materials can be further engineered to promote osteoinductivity through the incorporation of osteogenic biomolecules. A recently developed marker of high alcohol consumption, carbohydrate-deficient transferrin, was as good an indicator as the other conventional biochemical markers.

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Four patients presented in the eighth and ninth decades of life (70, 78, 87 and 89 years). Hypothalamo-anterior pituitary gonadotropin-releasing hormone and substance-P systems during the 17 beta-estradiol-induced plasma luteinizing hormone surge in the ovariectomized female monkey. The up-regulation of COX-2 by IL-1beta was accompanied by specific up-regulation of PGI synthase and PGE synthase, but not TX synthase.

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Quantification of CD1a, HLA-DR, and HLA class I expression on viable human Langerhans cells and keratinocytes. Moreover, data regarding other markers of disease activity, such as IGFBP-3 and acid-labile subunit (ALS), i.e. In these patients with no other therapeutic alternatives, re-irradiation and hyperthermia can provide durable tumour response for more than a year, resulting in significant improvement in quality of life.

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Thanks to the advances in micro- and nanofabrication during the last decades several manipulation techniques offer us the possibility to image, characterize and manipulate biological material in a controlled way. A second group of animals were primed with 10 micrograms OB and were then given either 0, 10, 50, 100, 250 or 500 micrograms Pr 3 h prior to testing. In 33 patients, the femoral vein was exposed by cutdown and ligated afterward.

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The patients were dialysed with a spool dialysator with cuprophan membrane of a surface of 1 m2. Vasoconstrictions were elicited by electrical stimulation of the renal nerves until renal vascular resistance stabilized. HIV transcripts were increased in the AD brains compared to non-demented controls but were detected only occasionally in spinal cord and not at all in peripheral nerve. This is of particular importance when the primary skin lesion is not readily identifiable, or has been inadequately managed in the past.

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Consistent with the finding that mAb SAC1 also labels spinal accessory nerves, these observations identify mAb SAC1 as a specific marker of spinal accessory motor neurons/axons. Sensitivity to inhibition by N-ethylmaleimide: a property of nitrobenzylthioinosine-sensitive equilibrative nucleoside transporter of murine myeloma cells. Instability of 8E5 calibration standard revealed by digital PCR risks inaccurate quantification of HIV DNA in clinical samples by qPCR.

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The averaged spectrum upon the complex formation was then compared with that in the conversion of rhodopsin-to-metarhodopsin II. Specifically, we present a refinement of a two-component model recently proposed for attractive colloidal suspensions, in which hydrodynamic effects related to the presence of the filler are properly taken into account using the concept of shear stress equivalent deformation. Monkeys were required to make 20 lever-press responses and then five inhalations on a smoking spout to obtain the first smoke delivery. CYC pulse regimen seems to stabilize alveolitis in the majority of cases. Induced Pluripotent Stem Cells of Microtus levis x Microtus arvalis Vole Hybrids: Conditions Necessary for Their Generation and Self-Renewal.

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Behavior of some hormones in pregnancy and their influence on carbohydrate metabolism conradae DNA by polymerase chain reaction (PCR) initially and then once or 3 times post treatment (60-210 days).

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Ingestion of lipids is not followed by an immediate increase in lipid oxidation, but FFA are stored as triglycerides in different tissues. Although no in vivo adverse effects, including enhancement of tumor growth, have been noted, in vitro studies suggesting a role for T alpha 1 in cell growth have been reported. The objectives of this study were to determine the functional antibody response to select staphylococcal exotoxins (LukAB, alpha-hemolysin, and PVL) in children with cystic fibrosis and to evaluate the relationship of this response with pulmonary exacerbations.

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Procyanidines from Vitis vinifera seeds protect rabbit heart from ischemia/reperfusion injury: antioxidant intervention and/or iron and copper sequestering ability. Persistent halogenated compounds in fish from rivers in the Pearl River Delta, South China: Geographical pattern and implications for anthropogenic effects on the environment. Requirement for IL-13 independently of IL-4 in experimental asthma. Surgical bypass for subclavian vein occlusion in hemodialysis patients. Evaluation of cytogenetic conversion to Ph- haemopoiesis in long-term bone marrow culture for patients with chronic myeloid leukaemia on conventional hydroxyurea therapy, on pulse high-dose hydroxyurea and on interferon-alpha.

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Participants were randomly assigned to either active rTMS treatment or wait-list (WTL) groups. The cell proliferative activity demonstrated in histological sections, by an immunohistochemical staining of proliferating cell nuclear antigen and Ki-67, showed no statistically significant differences among AH and a matched control group of normal palatal salivary glands.

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Reduction of plasma fibrinogen, immunoglobulin G, and immunoglobulin M concentrations by immunoadsorption therapy with tryptophan and phenylalanine adsorbents. These results are in contrast to historical series of chemotherapy alone which results in limited palliation of brief duration and almost no chance of cure.

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A 10-month-old, female Holstein-Friesian cow with tetralogy of Fallot died during surgery for ameliorating pulmonary stenosis. When added simultaneously with the injurious agent, 5-10 mM CaCl2 blocked the toxicity of physiological concentrations of deoxycholic acid, oleic acid, palmitic acid and linoleic acid. Multicenter, randomized clinical trials such as the Sunbelt Melanoma Trial are vital in answering the question of how best to treat early metastatic melanoma. Under the same photoperiod, but with the mean temperature ranging within known limits, it was possible to determine temporal characteristics of the system in the field by examining the effects of the light/dark and temperature daily cycles.

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Monosaccharide composition of glycopolymers depends both on the mollicute species and on its capacity to evoke diseases in different microorganisms. Correction of the hypothyroid state resulted in the normalization of CsA requirements, but overcorrection led to an increased requirement of CsA. The purified protease was active between pH 4.5 and 12.0 with optima at pH 6.0 and 11.5.