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Utilization of alpha-ketoisocaproate for synthesis of hepatic export proteins and peripheral proteins in normal and cirrhotic subjects. Structural unfolding of soy protein isolate (SPI) as induced by holding (0, 0.5, 1, 2, and 4 h) in acidic (pH 1.5-3.5) and alkaline (pH 10.0-12.0) pH solutions, followed by refolding (1 h) at pH 7.0, was analyzed. Hospitalised patients report a favourable disposition towards family witnessed resuscitation, and this view appears to be strengthened by successfully surviving a resuscitation episode. When added directly to the culture medium of gestational day 10-11 rat conceptuses, both compounds inhibited lysosomal cysteine proteinase activity in the VYS in a concentration-dependent fashion that correlated with the degree of embryotoxicity observed.

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Many proteins exist normally as oligomers or complexes with other proteins. SCO1 and SCO2 act as high copy suppressors of a mitochondrial copper recruitment defect in Saccharomyces cerevisiae. The rat specific features of the oocyte have long impeded the development of SCNT. To extend the study, a method of calculating cell recovery from centrifugation was developed, based on the experimental results.

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Heterogeneity of left ventricular regional wall thickening following dobutamine infusion in normal human subjects. In 250 subjects with normal lumbar spine and 39 patients with lumbar spinal canal stenosis (LSCS), radiographic measurement such as canal-to-body ratio (CBR), intervertebral space, inclination and thickness of the facet were performed to statistically evaluate normal degenerative changes in lumbar spine and the difference between normal degenerative changes and those of LSCS. This event correlates with an increased expression of the pro-apoptotic BH3-only protein Bim in the particulate fraction and a slight and late release of the pro-apoptotic mitochondrial protein Diablo/Smac in the cytosol. Of particular importance has been the role played by ECVAM, notably in partnership with ZEBET, in establishing the principles of test development, validation and acceptance, defining the practical procedures necessary to optimise the progress of new tests toward acceptance, and in successfully validating the 3T3 NRU PT test for phototoxic potential. This article describes the common patient complaints associated with TM disorders.

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The authors conclude that elderly women, Hispanic and black women, and women who reside in nonurban areas should be targeted as high-priority subpopulations for mammographic screening. Cadherins are transmembrane glycoproteins that bind cells by homophilic, homotypic interactions. Purification and properties of L-gulono-1,4-lactone oxidase from Grifola frondosa. In the present study, a large selection of spermine analogues has been tested for their effectiveness in inducing the production of antizyme, a key protein in feedback inhibition of putrescine synthesis and cellular polyamine uptake. Acute and chronic effects of Hypoxia can alter many of the neuropsychological functions in different altitudes due to physiological changes resulted by the oxygen (O2) partial decrease that can lead to neuropsychological alterations in individuals exposed to high altitudes.

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Percutaneous transvenous mitral commissurotomy for restenosis after surgical mitral valvotomy. Hypereosinophilia, ulcerative colitis, sclerosing cholangitis, and bile duct carcinoma. In previous studies a minority of WG patients as well as some healthy controls showed in vitro proliferation of their peripheral blood mononuclear cells (PBMC) to PR3, the main autoantigen in WG. Effects of sublethal ammonia exposure on swimming performance in rainbow trout (Oncorhynchus mykiss). Patients with symptomatic GERD demonstrated an increased incidence of BOS, but survival was not affected in this study.

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This is consistent with the above hypothesis regarding the evolutionary importance of demes. Photothrombosis of retinal and choroidal vessels in rabbit eyes using chloroaluminum sulfonated phthalocyanine and a diode laser. The effect of nitric oxide (NO) on the energy transfer reactions of mitochondria was examined under different oxygen tensions. The aim of this study was to examine the relationship between endogenous nitric oxide (NO) level and airflow obstruction in smokers using single-breath measurement of exhaled NO with the sequential breath-holding method.

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The origin and relative biological importance of the many different DNA-reactive antibodies that appear in systemic lupus erythematosus are not well understood. Intravenous administration of labetalol in the treatment of hypertensive emergencies

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We describe in this paper the general architecture of the HELIOS medical software engineering environment devoted to the development and maintenance of multimedia distributed medical applications. It is generally accepted that venous thrombosis in the lower extremity predisposes to pulmonary embolism. In the present study we investigated the bcl-2 expression on the protein level by means of immunohistochemical techniques including double confocal laser scanning microscopy, as well as on the RNA level by RT-PCR techniques, in Merkel cells, Merkel cell carcinomas, and cell lines. Suboptimal distal coronary flow reserve after successful balloon angioplasty has been attributed to angiographically unrecognized inadequate lumen expansion, and adjunct coronary stenting has been shown to improve coronary flow reserve.

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Acute abdomen and intestinal necrosis produced by varicella-zoster virus in an immunocompromised host. Explant cultures of catecholamine-containing neurons from rat brain: biochemical, histofluorescence, and electron microscopic studies. Hence, the properties of PAs and PRMs (mesoprogestins) open up new applications in gynecological therapy and hormone replacement therapy. At operation a large mass of compressing epidural fat was removed. Pigeons also produced a highly unexpected second peak in responding on nonreinforced PI trials at 3 times the FI duration.

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The brain blood vessels-the basilar artery and the internal carotid artery were injected with a mixture of gelatin and Indian ink. With our accelerated system, 6 x 10(9) cells were irradiated in nine cycles. Elasticity information may be derived by extracting frequencies from the wave patterns of phase-contrast MRE images. In various structures of the central nervous system except midbrain and cerebellum, the maximum binding capacity (B max) for 3H-Nicergoline is greater that for 3H-Prazosin. Rare CNVs and tag SNPs at 15q11.2 are associated with schizophrenia in the Han Chinese population.

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BaFe12O19 single-particle-chain nanofibers: preparation, characterization, formation principle, and magnetization reversal mechanism. The purpose of this article is to provide clinicians and clinical researchers the types of randomized clinical trials used in stroke studies and to discuss the advantages and the limitations for each type of randomized stroke clinical trials. Separation of some triazine herbicides and their solvolytic products by capillary zone electrophoresis. Our results suggest that chromosome 2 could harbor one or more genes implied in blood pressure homeostasis and MetS development.

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The kinetics of reaction between hemagglutinating antigens and immune sera to 10 hantavirus strains (7 isolated in the Primorye territory and 3 in other regions) was studied in the cross kinetic hemagglutination inhibition (KHAI) test. The events uncovered were the work of a group of forward-thinking surgeons who made considerable progress against opposing groups with more conservative views and whose contributions to Spanish surgery were far less brilliant. Subcellular dye localizations are not observed when the cells are loaded with other putative cytosolic stains that gain access to the cytosol by means of a membrane permeant ester.

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A future end-point of bone-protecting therapy is the demonstration of its ability to prevent or improve results in the treatment of metastatic disease, enlarging their clinical indications in metastatic and osteoporotic setting with different schedules. The data presented here suggest a role of this protein in the biology of malignant cells in chronic granulocytic leukemia throughout the course of the disease.

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Interleukin-2 (IL-2) is a potent immunomodulator that has been associated with the clinical development of autoimmune disorders. A standardized questionnaire to assess the RLS phenotype, history of CVD and hypertension, sleep and depressive symptoms, drug intake and demographic/clinical features was sent to the France-Ekbom Patients Association members.

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Isolation, characterization and chromosomal assignment of human colligin-2 gene (CBP2). The Role of Alpha-MSH as a Modulator of Ocular Immunobiology Exemplifies Mechanistic Differences between Melanocortins and Steroids. Both famotidine and omeprazole reduced the sialic acid content during and after treatment. A delayed non-match-to-sample (DNMTS) eight-arm maze task was used to study spatial working memory. Patients with a very-low- or low-probability V/Q scan interpretation, an intermediate or high clinical likelihood of PE, and negative serial noninvasive venous studies of the lower extremities do not require anticoagulation or angiography.

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Extensive research has been conducted in the treatment of heart failure. The clinical significance of p53 mutation, p53 overexpression, and low-level HER-2/neu expression in benign breast tissue remains to be determined. The Ral-glucosylating toxin is a novel isoform of Ras-modifying clostridial cytotoxins.

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These findings are consistent with the notion that neuronal melanocortins influence how frogs and toads gather information about their environment during stress. Extremely few data are available about the natural history of parenteral nutrition (PN)-associated cholestasis. The presence of unstable angina points to the severity of the culprit lesion, but it does not necessarily inform about the extent of coronary artery disease. To assess and compare the validity of six physical function measures in people awaiting hip or knee joint replacement. The volumetric contraction of dental gypsum materials on setting.

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After hatching, neonates move out of the soil and may use chemical cues to search for new hosts. Intracoronary administration of rFGF-2 appears safe and is well tolerated over a 100-fold dose range (0.33 to 0.36 microk/kg). These data demonstrate that QUIS is taken up by a select group of neurons in the rat hippocampus. In two control experiments the subjects had to determine the position of the centres of each stimulus and of the reference circle.

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Calculation of hydrodynamic mass for atomic impurities in helium. Immunohistochemically, desmin was positively detected in not only autopsy materials but also undifferentiated cells of the surgical specimens, suggesting prospective myoblastic differentiation. Morpholino antisense oligonucleotide-mediated RARalpha loss-of-function phenocopied the effects of RA treatment and dominant-negative corepressor expression.

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Basic trends of the research dealing with the historical-scientific analysis of the backgrounds, tendencies, and perspectives of gerontology are discussed. TDPS and panc-1 cells were grown in coculture to determine directional migration and panc-1 invasiveness was quantified using Matrigel invasion chambers, comparing TDPS cells to human foreskin fibroblasts (HFFs). Using an innovative high-frequency Doppler system, we noninvasively characterized circulatory hemodynamics in early mouse embryos.

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L-glutaminase-asparaginase biosynthesis by a Pseudomonas boreopolis culture dependent on cultivation conditions These reference values encompass a wide age range for three race/ethnic groups and should prove useful for diagnostic and research purposes. Independently of their H-ras status, all in vivo-progressed tumor cell lines (five of five) exhibited a constitutive and stable expression of the hematopoietic growth factors granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor, which may function as autocrine/paracrine mediators of tumor progression in vivo. Malignant melanoma affects all age groups, but its highest age-specific incidence is in the elderly. The patient received epinephrine, norepinephrine and dopamine to maintain mean arterial pressure above 55 mm Hg.

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A comparative study of six commercial lipoprotein(a) assays in seventeen laboratories within the British Isles. Prostaglandins prevent inducible nitric oxide synthase protein expression by inhibiting nuclear factor-kappaB activation in J774 macrophages.

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More active management of extremely low birthweight infants before transfer to a level-III centre, including prompt referral and transcutaneous PO2 monitoring during transport, may be important in improving the sensorineural outcome of survivors. Neurites of all ages grew along the roots to the DREZ, where their ability to cross into the spinal cord depended on both their age and that of the spinal cord substrate. The year 1994 is likely to be remembered by many endocrinologists as the year in which dramatic new light was shed on the role played by estrogen in human skeletal physiology. Otefin is a 45-kDa nuclear envelope protein with no apparent homology to other known proteins. Cryptogamic vegetation dominates the ice-free areas along the Antarctic Peninsula.

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The accident at the Chernobyl nuclear power station occurred in April 1986. This form of stress-induced hypoalgesia represents a response to unconditional fear or anxiety.

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The purpose of this study was to analyze the relationship of the main hormonal and metabolic abnormalities in PCOS with different levels of TSH in the limits of its reference values. Traumatic thoracobiliary (pleurobiliary and bronchobiliary) fistulas: clinical and review study.