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Cell growth rate was examined after treatment for 4, 7, and 10 days with RA and/or IFN-alpha of human papillomavirus type 18 (HPV 18)-immortalized endo- and ectocervical cells, nontransformed serum-adapted cells, transformed cells, three adenocarcinoma, and three squamous cell carcinoma cell lines. Allelic imbalance at p53 and microsatellite instability are predictive markers for resistance to chemotherapy in gastric carcinoma. The 452,000 inhabitants of the County of Funen are considered to constitute a representative section of the population of Denmark. The development of resource material, testing methods and the changed role of the teacher in Mastery Learning techniques are discussed.

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Preservation of annuloventricular continuity through the chordae tendinae aims to maintain left ventricular (LV) function and thus improve postoperative prognosis. Strong staining was detected in the shell sector of the nucleus accumbens, in the lateral septum, in subregions of the extended amygdala, in some areas of the hippocampus and of the hypothalamus, in the locus coeruleus, in the Purkinje cells of the cerebellum and in the dorsal horn of the spinal cord.

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We aimed to compare the placental component and pregnancy outcome in pregnancies complicated with PTB of singletons vs. Immunosuppression, liver injury, and hepatitis in renal, hepatic, and cardiac homograft recipients: with particular reference to the Australia antigen. None of the necropsied squirrels exhibited specific clinical signs associated with B. The format of the paper is a combination of didactic review and eight case reports in a self-learning format. A pilot randomized clinical trial was performed to determine the effectiveness of a 12-week post-radiation exercise program in minimizing upper extremity dysfunction in YA with BC.

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Theoretical investigation of transgastric and intraductal approaches for ultrasound-based thermal therapy of the pancreas. Trauma is a leading cause of death worldwide and a major health problem of the modern society.

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Vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2) are major mediators of angiogenesis and are induced by tissue inflammation and hypoxia. Spirometry was carried out at yearly intervals, and a questionnaire relating to respiratory symptoms and smoking habits was completed annually by all participants.

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We conclude that the neuroprotective effect of AGE in the 0R treatment might be associated with control of the free-radical burst induced by reperfusion, preservation of antioxidant enzyme activity, and the delay of other pathophysiological processes. The endobronchial ultrasound elastography can effectively distinguish the mediastinal and hilar lymph node metastasis in lung cancer. Permanent brachial plexus birth palsy does not impair the development and function of the spine and lower limbs. The sequence analysis of these alleles reveals that a limited and particularly distinct number of amino-acid positions are relevant for either interaction only. There is a constant alternance between glucose storage as glycogen after meals and glycogen mobilization in the postabsorptive state when plasma glucose has returned to the basal state.

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Ankle brachial pressure index in systemic sclerosis: influence of disease subtype and anticentromere antibody. Amplification of chromosome 11q13 leads to overexpression of a G1 cyclin gene, cyclin D1 (PRAD-1, CCND-1), in many non-cervical human carcinomas. The mspTL gene has a 1770-bp open reading frame (ORF) encoding a protein of 590 amino acids with a predicted molecular mass of 65 kDa which had a typical prokaryotic signal sequence (19 amino acids). Medical short stay unit for geriatric patients in the emergency department: clinical and healthcare benefits Bombesin may affect the blood-flow to the gastrointestinal canal, possibly via a direct effect on vascular smooth muscle.

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Differences in defense mechanisms and dynamics and their working through, however, can make unfamiliar the factors that are basic to any psychotherapy. A 20-min isolated hypoxic perfusion was performed after 40 mg of mitomycin C (MMC) had been instilled into the running perfusion system over 5 min. Atypical microorganism infections, including Chlamydophila pneumoniae, play an important role in asthma course. Hysterectomy performed via the Maylard incision was associated with the use of fewer additional analgesics than hysterectomy performed via the Pfannenstiel incision. Thirty patients underwent laparoscopic RYGB and 31 received standard medical therapy combined with a diabetes support and education program (DSE), consisting of educational sessions on diet and exercise.

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In the diagnosis of the involvement into the process of the right parts of the heart kinetocardiography and changes in the PV1 angle on the ECG proved to be most informative. There was also no difference in concentration of mono- and diphosphates of adenosine. The results provide evidence against the argument that mirror neuron dysfunction improves with age in individuals with ASD and suggest, instead, that a diagnosis-independent developmental change may be at the root of the correlation of age and mu suppression.

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Western immunoblot analysis confirmed that protein levels for both leucine(5)- and methionine(5)-ENK were significantly decreased in tissue samples containing the LC after chronic morphine treatment. Effects of long-term partial outflow obstruction on bladder function in the rat. Clinical, electrophysiological and molecular genetic characteristics of 93 patients with X-linked Charcot-Marie-Tooth disease. 104 men and women were tested for visual field-hemispheric transfer of spatial information on a dot-localization task.

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This noninvasive, rapid, whole-blood assay of stress thrombopoiesis provides reproducible indices for timing platelet recovery following chemotherapy and the potential to optimize the use of prophylactic platelet transfusions in chemotherapy patients. Relative risks (RR) were adjusted by relevant confounders (blood pressure, serum cholesterol, diabetes mellitus, smoking habit, high alcohol consumption, history of previous IHD, cancer, and other diseases). No reactions were seen after infusion when we scrapped the last 50 to 100 ml of drained blood. A comparison of recurrent and primary herpes simplex keratitis in NIH inbred mice.

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Class I includes glycoprotein genes that are nonessential for virus replication in vitro, and Class II includes genes involved in nucleic acid metabolism. However, certain drugs undergo biotransformation to metabolites that can interfere with cellular functions through their intrinsic chemical reactivity towards glutathione, leading to thiol depletion, and functionally critical macromolecules, resulting in reversible modification, irreversible adduct formation, and irreversible loss of activity. Mucinous syringometaplasia is a benign, presumably reactive verrucous lesion most commonly occurring on acral sites.

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In multilayered cultures, total PTHrP secretion and mRNA expression remained high in both SCC 2/88 and SCC-A253 cells, and secretion by the multi-layered cultures was principally in the basal direction. By contrast, there were no differences in the HPA axis reactivity between testing session t2 and t3.

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Histopathologic evaluation was not compromised by the use of this device. The role of spatial position in selective visual processing has been the source of recent debate. The results provide further evidence that heparin-binding peptide regions are multifunctional, but also illustrate that cationicity alone is not sufficient for AMP function at physiological conditions. The increase in this enzyme activity would result in enhanced polyglutamation of folates and classical antifolates and thus increased cellular retention.

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Underground Waters as Sources of Public Water-Supplies in Ontario. The early history of private education of western medicine for women Neurokinin-induced changes in pial artery diameter in the anaesthetized guinea-pig. Larval membrane antigens protect Hereford cattle against infestation with Boophilus microplus.

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The data are discussed in terms of current theories on endogenous antioxidant mechanisms. By 7 days, there was a 2-fold increase in both BDNF and trkB mRNA expression. It was less efficient in gnotobiotic rats than in mice and less efficient in gnotobiotic mice fed an autoclaved diet than in mice fed the same diet sterilized by irradiation.

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S14080 had no significant effect on the inflammatory oedema induced by carrageenin or on the tail flick test, nor did it possess a notable antipyretic effect. The role of dexfenfluramine in the regulation of energy balance.

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Some SLN formulations already showed aggregation/particle growth in the presence of electrolytes at neutral pH. An other argument is that the shortening of REM latency and the increased amount of REM sleep in the first half of the night are evidences of the excess of REM sleep and at last, most antidepressant drugs are REM suppressors and may act through REM sleep suppression.

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Embryonic stages: morphology, timing, and variance in the toad Bombina orientalis. Apple-type undulators are globally recognized as the most flexible devices for the production of variable polarized light in the soft X-ray regime, both at synchrotron and free-electron laser facilities.

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The organism was isolated from cultures of blood and vegetations on the tricuspid valve, interatrial septum and the pacing wire removed at surgery. The role of the appropriately trained nurse in meeting these needs has been well researched and published literature supports the development of such roles. These closely related strains harbor 225 to 493 genes absent from the P. Of interest, susceptibility did not relate to PKC activity or its inhibition by UCN-01. Patients with severe bone marrow involvement may have a guarded prognosis.

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Increased removal of DNA-bound platinum in a human ovarian cancer cell line resistant to cis-diamminedichloroplatinum(II). The simplest possible sequence, three-pulse SERPENT, measures displacements in two interleaved time intervals, while in VEXSY, consisting of two independent pairs of gradient pulses separated by a mixing time, displacements during the two encoding intervals are compared to each other.

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The authors examined whether the administration of 5-fluorouracil (5-FU) enhanced apoptosis of gastric carcinoma cells, and investigated the relationship between apoptosis and the expression of Ki-67 and the Bax gene. The antinociceptive effect of fluoxetine was sensitive to blockade by naloxone (5 mg kg(-1), i.p.) and naltrexone (5 mg kg(-1), i.p.). By use of an in vitromicrovascular technique, we have shown pregnancy-associated alteration in adrenergic responses in the uterine microcirculation of the rat.

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In experiment 3, exposure to smoking-related cues significantly elevated factor 1 scores, but not factor 2 scores, in tobacco chippers. Analysis of the Ser786Pro interleukin-4 receptor alpha allelic variant in allergic and nonallergic asthma and its functional consequences.

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Membrane and soluble forms of Fas (CD95) in peripheral blood lymphocytes and in serum from burns patients. A procedure has been described for the modification of the amino group of glycine methyl ester, and the amino groups of the hormone, insulin, with the reagent p-nitrophenyl-p-chloromercuribenzoate, effecting the introduction of the chloromercuri group at various defined sites in the protein molecule. Detection of schistocytes on a peripheral blood smear is an abnormal finding, which raises the occurrence of a microangiopathy.

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Isonicotinic acid hydrazide in cutaneous tuberculosis and leprosy The trend today is for patients to be more involved in healthcare and decision-making. Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients. Blood carnitine levels were altered in patients with increased total and esterified carnitine concentrations and enhanced acyl/free carnitine ratios. Although useful for hydrophobic surfaces, this approach is limited for hydrophilic mats, where wicking also has to be considered.

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The overall effect of increasing ABA biosynthesis depends on the relative weight of each of these effects under different environmental scenarios. Cold-restraint stress decreased the gastric mucus content and induced haemorrhagic erosions in the glandular stomach. Different degrees of maternal hyporesponse, as far as blocking activity is concerned, are proposed for primary chronic abortion, preeclampsia, and idiopathic intrauterine growth retardation. To determine the level of cardiorespiratory fitness and to establish factors limiting the maximal effort during the ergometry. The induction of tissue factor by gp120 is mediated by two biologically relevant coreceptors for HIV infection, CXCR4 and CCR5, and is also dependent on the presence of functional CD4.

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CDK7 can also phosphorylate CDKs that promote cell cycle progression, and has been shown to function as a CDK-activating kinase (CAK) in Schizosaccharomyces pombe and Drosophila melanogaster. One of them is allergic bronchopulmonary aspergillosis (ABPA) characterized by pulmonary eozynophilia, asthma, an allergic type of immune response in the bronchi and proximal bronchiectases. The DNA sequence of one of the smallest eukaryotic genomes has recently been finished - that of the reduced nucleus, or nucleomorph, of an algal endosymbiont that resides within a cryptomonad host cell.

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Studies were identified and selected, and two independent reviewers extracted data from the studies. Identification of triacylglycerols containing two short-chain fatty acids at sn-2 and sn-3 positions from bovine udder by fast atom bombardment tandem mass spectrometry. Some schizophrenic patients have higher levels of both amines than do controls, though the differences in distribution did not reach statistical significance in the sample studied.

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This policy was modified when penicillin-resistant Streptococcus pneumoniae isolates were found to be markedly less susceptible to ceftizoxime than to cefotaxime, of concern considering the prevalence and virulence of this pathogen. Policy-level changes at the state and community led to lasting changes in the organization and financing of care, which enabled changes in clinical services to take place. Both tumors and conceptusses are faced with a similar problem -- how to grow in a host in a vascular rich area, and yet escape immune surveillance despite both entities being an allogenic stimulus. Comparison of nuclear and cytoplasmic levels of TBP mRNA in liver and testis suggested that nuclear events (transcription or processing) contribute roughly 12-fold, and cytoplasmic events (mRNA stability) roughly 6-fold, to testis-specific overaccumulation.

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The 5-year-old had an immunoglobulin E value of 1119 iu/L with normal values of other immunoglobulin classes. Data sources are archival documents about the male founders of the Friends Asylum, its constituent families, and the committees responsible for the creation and the maintenance of the institution. In this work, the Langmuir technique and atomic force microscopy were employed to investigate the interactions of two novel lipopeptides with negatively charged phospholipid membranes, which served as a simplified model of inner membrane of Gram-negative bacteria. Activated T cells of low grade gastric MALT lymphoma, while delivering full help to B cells, are apparently deficient in two cytotoxic mechanisms involved in the concomitant control of B cell growth.

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Sexual behavior and functioning is an important aspect of quality of life but is frequently overlooked in research studies as well as clinical care. A proportion of the Ad12 E1B 54K protein in both the high- and the low-molecular-weight populations in the nucleus was found to form a complex with p53, and it is therefore concluded that the very high molecular weight derives from interaction with an, as yet, unidentified component. Effect of composite insertion technique on cuspal deflection using an in vitro simulation model. 40 patients with American cutaneous leishmaniasis caused primarily by Leishmania braziliensis panamensis were treated with sodium stibogluconate in a double-blind, randomised controlled trial. These cases illustrate the close links between dysfunction of the limbic system causing epileptic seizures and psychosis on the one hand and dysregulation in hypothalamic centers manifestating in polydipsia and osmodysregulation on the other.

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Of the basic science studies, two investigations found evidence that favored total hip arthroplasty, while three favored resurfacing hip arthroplasty. The cell composition, viability and functional activity of the phagocytizing cells of cervical and endometrial secretions, as well as peritoneal exudate, were studied. A multivariate logistic model, controlling for age, was used to assess the independent effects of factors found to be significantly associated with endometrial cancer on univariate analysis. Movement Disorder Society Symposium on Cortical-Basal Ganglionic Degeneration (CBGD) and its Relationship to Other Asymmetrical Cortical Degeneration Syndromes (ACDs). An increase in its incidence coincided with the introduction of cyclosporin in the 1980s.